Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
Báo cáo y học: "Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes" ppt
... small-molecule inhibitor of the binding of insulin-like growth factor (IGF) -1 to IGF -binding proteins, on 12 5 I-labeled IGF -1 binding to human osteoarthritic chondrocytesEffect of NBI- 317 72, a small-molecule ... article Pharmacological disruption of insulin-like growth factor 1 binding to IGF -binding proteins restores anabolic respon...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Pharmacological evaluation of tacrolimus (FK-506) on ischemia reperfusion induced vasculatic neuropathic pain in rats" ppt
... RJ: Changes in cerebrospinal fluid levels of proinflammatory cytokines in CRPS. Pain 2005, 11 6: 213 -19 . 3. Ludwig J, Baron R: Complex regional pain syndrome: an inflammatory pain condition? ... 18 .94 ± 1. 74 a 24.54 ± 1. 56 a 18 . 31 ± 1. 58 a 16 .42 ± 2.23 a Vehicle 0.86 ± 0.23 18 . 61 ± 1. 34 a 25.59 ± 1. 61 a 17 .39 ± 1. 57 a 17 .14 ± 2. 01 a Tacrolimus (1) 0....
Ngày tải lên: 10/08/2014, 10:20
Báo cáo Y học: Domain V of m-calpain shows the potential to form an oblique-orientated a-helix, which may modulate the enzyme’s activity via interactions with anionic lipid potx
... daphoenix@uclan.ac.uk Abbreviations:Myr 2 PtdCho, dimyristoylphosphatidylcholine; Myr 2 PtdEtn, dimyristoylphosphatidylethanolamine; Myr 2 PtdSer, dimyristoylphosphatidylserine; FTIR, Fourier transform infrared; SUV, ... (19 98) An investigation into the lipid interactions of peptides corresponding to the C-terminal anchoring domains of Escherichia coli penicillin- binding proteins...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein–protein interactions pdf
... with GST-CBP 1) 110 0 , GST-CBP 18 92)24 41 or their combination did not result in any activation of the ISRE · 3CAT reporter (Fig. 6B). The inability of GST-CBP 1) 110 0 and GST-CBP 18 92)24 41 , alone or in ... experi- ments. Proteins retained on the GST fusions were analyzed by SDS/ PAGE and autoradiography. 20% of IRF-3 protein input is shown on the right. Binding to...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: The reactivity of a-hydroxyhaem and verdohaem bound to haem oxygenase-1 to dioxygen and sodium dithionite pdf
... ferrous complex was mainly formed through reduction of free a-hydroxyhaem by dithionite followed by its direct binding to the enzyme, rather than by reduction of the enzyme-bound ferric a-hydroxyhaem, as ... 4, 2 21 227. 9. Yoshida, T., Noguchi, M., Kikuchi, G. & Sano, S. (19 81) Degradation of mesoheme and hydroxymesoheme catalyzed by the heme oxygenase system: Involvement of...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo y học: "Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation" pot
... heterogeneity of IL -1- induced GAG depletion to study the relative replenishment rates between regions of varying severity of GAG depletion. Accordingly, our goal was to use dGEMRIC to determine whether ... recovery over the subsequent 3–4 weeks. Arner [1] also examined in vivo GAG synthe- sis and accumulation in rabbits following intra-articular injections of IL -1. Using...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "Increased expression of FcγRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus" ppsx
... protein: ligands, receptors and role in inflammation. Clin Immunol 2005, 11 7 :10 4 -11 1. 22. Bang R, Marnell L, Mold C, Stein MP, Clos KT, Chivington-Buck C, Clos TW: Analysis of binding sites in human ... in phagocytosis, cytolysis, degranu- lation, and induction of inflammatory cytokines. Additionally, FcγRI-deficient mice display defective peritoneal monocyte infiltration...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus" potx
... g for 10 min. The capacity of urea/EDTA-modified CRP and native CRP to block antibody binding to solid-phase CRP in sera was measured by adding increasing amounts of native or mCRP to 11 anti-CRP ... environmental, and infectious risk factors for developing systemic lupus erythematosus. Arthritis Rheum 19 98, 41: 1 714 -17 24. 2. Robson MG, Walport MJ: Pathogenesis of syste...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "The induction of CCN2 by TGFβ1 involves Ets-1" ppsx
... four protein mod- ules sharing identity with insulin-like growth factor binding proteins, Von Willebrand factor, thrombospondin, and a cysteine knot-containing family of growth regulators [2]. CCN2 ... The bisindolylmaleimide GF 10 9203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 19 91, 266 :15 7 71- 157 81. 21. Leask A, Byrne C, Fuchs E: Transcr...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Mesangial cells of lupus-prone mice are sensitive to chemokine production" pps
... and AP -1 activation in human proteinuric renal disease. Kidney Int 20 01, 60 :13 66 -13 77. 10 . Rovin BH, Yoshiumura T, Tan L: Cytokine-induced production of monocyte chemoattractant protein -1 by cultured ... S A 2004, 10 1: 418 6- 419 1. 30. Chan RW, Lai FM, Li EK, Tam LS, Wong TY, Szeto CY, Li PK, Szeto CC: Expression of chemokine and fibrosing factor mes- senger RNA in...
Ngày tải lên: 09/08/2014, 10:20