... for DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid. Hypoxanthine and guanine may enter in a sal-vage pathway, using hypoxanthine-guanine ... analogous of hypoxanthine, inhibitor of xanthine oxi-dase, the last enzyme involved in uric acid synthesis pathway. It catalyzes the conversion of hypoxanyhine into xanthine and this latter into ... raises the risk of morbidity and mortality, even in patients potentially curable. TLS is defined as the presence of at least 2 of the following laboratory data: hyperuricemia, hyper-kalemia, hyperphosphatemia,...