Báo cáo y học: "Anti-Sa antibodies: prognostic and pathogenetic significance to rheumatoid arthritis" doc

... autoantibodies and inflammatory arthritis. Science 2002, 297:1689-1692. 23. Schaller M, Burton DR, Ditzel HJ: Autoantibodies to GPI in rheumatoid arthritis: linkage between an animal model and human ... vimentin, and the typically low cytoplasmic concentrations of calcium would not allow this to occur [18,19]. Deimination of vimentin by PAD probably occurs in macrophages when they...

Ngày tải lên: 09/08/2014, 01:23

... for this study were enrolled in the FAST 4WARD (efficacy and safety of certolizumab pegol monotherapy every 4 weeks dosage in rheumatoid arthritis) study, a 24-week, mul- ticenter, randomized, ... Innes A, Strand V: Effi- cacy and safety of certolizumab pegol monotherapy every 4 weeks in patients with rheumatoid arthritis failing previous disease-modifying antirheumatic therapy: the F...

Ngày tải lên: 09/08/2014, 14:21

... by CD4+ T and B lymphocytes [1,21]. Under inflammatory conditions such as allergy and arthritis, NGF can be produced, stored, and released by eosinophils, mast cells, lymphocytes, and synovial ... have recently also Figure 4 NGF staining by flow cytometryNGF staining by flow cytometry. PBMC of (a) healthy controls (HC) and (b) synovial fluid mononuclear cells (SFMC) from spondyloart...

Ngày tải lên: 09/08/2014, 14:21

... switching and plasmacytoid differentiation. Autoantibody production is facilitated by the ability of DNA/RNA-containing autoantigens to activate B cells directly by simultaneous binding to BCR and ... prominent immunoregulatory effects and might act as key cytokines, not only in the innate immune system but also in adaptive immune responses. Immunomodulatory effects by type I IFNs T...

Ngày tải lên: 09/08/2014, 01:21

... Disturbances at any level can lead to changes in susceptibility to, and severity of, autoimmune/inflammatory disease. A thorough under- standing of the mechanisms by which the CNS and immune systems communicate ... neuroendrocrine systems. Cytokines and their receptors are expressed in the neuroendocrine system and exert their effects both centrally and peripher- ally [100–102]....

Ngày tải lên: 09/08/2014, 01:23

... pathways and identify susceptibility genes or susceptibility effects that might be epistatic, additive or independent. Similarly, the psoriasis study analyzed a region previously identified by linkage ... epigenetic silencing in cytotoxic lineage thymocytes [30]. RUNX3- deficient cytotoxic T cells, but not T helper (Th) cells, were reported to have defective responses to antigen, sugges...

Ngày tải lên: 09/08/2014, 01:23

... of the study and drafted the man- uscript. JD carried out the flow cytometry assay and the chem- otaxis assay, performed the statistical analysis and helped to draft the manuscript, and is one ... (OA CD147) syn- ovium. CD147 was predominantly expressed by macrophage-like cells and fibroblast-like synovial cells in the lining layer and partly by endothe- lial cells in the rheum...

Ngày tải lên: 09/08/2014, 06:23

... clinical amyloidosis, rheumatoid vasculitis, eye dis- ease, interstitial lung disease, rheumatoid nodules, Felty's syn- drome, or anterior atlantoaxial luxation), rheumatoid factor positivity, serum ... significantly (20%, 20%, 14%, 16%, and 16%, annually from 2000 to 2004). Both the percentages of patients on any DMARD monotherapy (from 57.8% to 59.8%, 2000 to 2004) or on...

Ngày tải lên: 09/08/2014, 13:22

... All authors read and approved the final manuscript. Acknowledgements This study was sponsored by grants from the Muscular Dystrophy Society and by Geisinger Health System to Yiumo Chan References 1. ... Neurophysiologic Monitoring. Humana Press (Totowa NJ); 2005. 2. Happel L, Kline D: Intra-Operative neurophysiology of the peripheral nervous system in Neurophysiology in Neurosur- gery:...

Ngày tải lên: 10/08/2014, 10:20

... cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific inte- grin receptors and by collagenase inhibitors. Arthritis Rheum 1997, 40:1298-1307. 10. Arner EC, Tortorella ... further attention. By focusing on cytoskeletal rearrangement and cell migration, Zeng and coworkers [4] address only part of the several pathways that have been linked to Src and F...

Ngày tải lên: 09/08/2014, 01:22