Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx

... and Drug Administration; RCT = randomized controlled trial. Arthritis Research & Therapy Vol 6 No 3 Fries and Krishnan Research article Equipoise, design bias, and randomized controlled trials: ... to accept the trial upon the pooled expectation for the RCT arms and not upon the value of any single arm. The principle of ‘equal uncertainty between the...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 06:22

... ophthalmology, dermatology, dentistry and rheumatology [10,11]. Based up on these data the aim of this study was to observe the potential of Esterified Hyaluronic Acid (EHA) as a coadjuvant of grafting ... PATIENTS AND METHODS Study drug Hyaloss® matrix, trade names of products composed entirely of an ester of hyaluronic acid with benzyl alcohol (HYAFF™) [2],...

Ngày tải lên: 03/11/2012, 11:35

... 9 of 10 by linear regression analysis by plotting the specific bindin g of the radioligand on th e X-axis and bound/free on the Y- axis. The maximal binding is a measure of the total number of ... in the tissue and the equilibrium dissociation constant is the measure of the affinity of the receptors for the radioligand. The K d is inversely related to...

Ngày tải lên: 10/08/2014, 05:21

Ngày tải lên: 25/10/2012, 10:02

... regimen might influence the immediate postoperative period especially the pain scores and the length of stay in the post anesthetic care unit (PACU). In this open randomized study, we compared postoperative ... any analgesic medication or corticosteroid drug prior surgery. They were instructed the day before surgery about the study design and to express their pain...

Ngày tải lên: 02/11/2012, 10:14

... where the system is dynamic but under little control, in the case of postural sway the system is swaying equally on either side of the stable position. The researchers consider an indicator of ... means by which to quantify a non-linear system and as such may be more readily accepted by clinicians. The potential of the fractal dimension analysis is yet to be realiz...

Ngày tải lên: 03/11/2012, 10:09

... Sweden) and the bands were revealed by silver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft- ware (BioSystematica, Plymouth, UK). The ... assigning the patients to various categories, we set the intensity of the 676-bp band of the molecular mass marker on each gel as the arbitrary cutoff point (Fig. 1,...

Ngày tải lên: 09/08/2014, 01:23

... deposition and compromising the physical integrity of the membrane. Central to the pathogenesis of lupus is continuous activation and proliferation of B-lymphocytes and T-lymphocytes with specificity ... by the MMPs would facilitate the deposition of immune complexes by compromising the integrity of the glomerular membranes. In this manner, the combined presenc...

Ngày tải lên: 09/08/2014, 13:22

... range of fields, who had expected that the number of genes to be a measure of organismal complexity. Furthermore, the imprecision of the estimate raised questions about the validity of many predicted ... the reference human genome at NCBI. ey identified around 5 Mb of novel sequence in each of the new genomes, and they estimate that the human ‘pangenome’,...

Ngày tải lên: 09/08/2014, 20:21