Báo cáo y học: "Enhanced osteoclast development in collagen-induced arthritis γ in interferon-γ receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis" docx

... before differentiation into osteoclasts. Interestingly, levels of calcitonin receptor mRNA were higher in IFN-γR KO than in wild-type mice, confirming the increased presence of osteoclasts in the mutant mice. Increased ... al. Research article Enhanced osteoclast development in collagen-induced arthritis in interferon- γ receptor knock-out mice as related...

Ngày tải lên: 09/08/2014, 01:23

... pro-apoptotic factors into the cytoplasm, such as cytochrome C, second mitochondrial activator of caspases (SMAC/Diablo) or apoptosis-inducing factor (AIF) [40]. Our study showed an increased activity ... pro-apoptotic family members, exerts its effects by compromising the membrane integ- rity leading to leakage of apoptogenic factors such as cytochrome c into the cytosol, resulting...

Ngày tải lên: 10/08/2014, 05:21

... have indicated that induction of CIA involves initia- tion of an inflammatory process via the classical comple- ment pathway and also via binding of IgG immune complexes to certain Fcγ receptors ... resulted in significantly higher IgG 1 anti- BCII antibody activity and increased splenocyte secretion of IFN -γ and IL-10 in response to BCII. Our findings demonstrate that OVA-specifi...

Ngày tải lên: 09/08/2014, 01:23

... the true incidence of infection. This is due to the majority of childhood HB cases being asymptomatic. While these factors may affect the yearly incidence estimate, changes in the incidence ... over reasonably long time periods. They are useful in defining risk groups and monitoring changes in the population. Over the last 5 years, universal school-based vaccination strategies,...

Ngày tải lên: 02/11/2012, 11:08

... inflammatory protein [MIP]-1, DN = double negative; H & E = hematoxylin and eosin; IFN = interferon; IL = interleukin; IP-10 = interferon -γ- inducible protein 10; MIP = macrophage inflammatory protein; ... inflammation in lupus-prone mice. In contrast to the findings of other investigators and the present study, Peng and colleagues [33] demonstrated using cytokine knock-out mic...

Ngày tải lên: 09/08/2014, 01:23

... thus, in the pathogenesis of RA. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by hyperplasia of synovial lining cells, consisting of macrophage-like type ... monoclonal antibody or phycho- erythrin-conjugated normal mouse IgG1, followed by analysis with flow cytometry. The NFκB1 protein levels as expressed by mean fluores- cence intensity were...

Ngày tải lên: 09/08/2014, 07:20

... area adjacent to the main defect from patients in the late stages of OA, an increase in staining intensity was found in the pericel- lular space (Figure 4b). In healthy cartilage, COMP staining was also ... Earlier, COMP was detected in the normal growth plate of primates [35] and was shown to bind to adult normal bovine chondro- cytes in vitro [8]. COMP was also shown to...

Ngày tải lên: 09/08/2014, 07:20

... recent studies indicate that the CPT provokes increases in cortisol and norepinepherine as well as producing increases in pro-inflammatory cytokine production [16,17]. In the present protocol, participants ... responses to stress appear to play a role in chronic inflammatory diseases such as rheumatoid arthritis (RA). However, relatively little stress research in RA pati...

Ngày tải lên: 09/08/2014, 14:20

... role of IL-6-type cytokines on bone remodeling and bone tumors. Cytokine Growth Factor Rev 2009, 20:19-28. 10. Haynes DR: Inflammatory cells and bone loss in rheumatoid arthritis. Arthritis Res ... impact on in vivo inflammatory immune response. (a) IgG anti-collagen II antibody levels from the DCA-drinking group and the water-drinking group. (b) Serum pro-inflammatory cytokine intere...

Ngày tải lên: 09/08/2014, 14:22

... terpenes could be classified into five groups: 1) entry inhibitors, 2) reverse transcriptase inhibitors, 3) protease inhibitors, 4) virus maturation inhibitors that do not inhibit HIV-1 pro- tease and 5) ... confocal laser micros- Evaluation of C14 inhibitory activity on HIV-1 DNA content into primary cellsFigure 2 Evaluation of C14 inhibitory activity on HIV-1 DNA content into primary cells...

Ngày tải lên: 10/08/2014, 05:21