Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt

... significantassociation of the 1G- 5A haplotype with radiographic damage. The 1G- 5A haplotype explained the variability of the Ratingen score in the same order of magnitude as the SE. Our data suggest that ... analysis Radiographic damage of hands and feet was assessed by the Ratingen score [28], a modification of the Larsen score.It evaluates 38 joints separately (all proximal inter-phalangeal and ... the results of the genetic analyses.At the Rheumaklinik Ratingen, radiographs of both hands and feet are routinely obtained for all RA patients atdisease onset and every 2 years thereafter, to evaluateradiographic...

Báo cáo y học: "Validation of a specific measure to assess healthrelated quality of life in patients with schizophrenia and bipolar disorder: the ‘Tolerability and quality of life’ (TOOL) questionnaire" doc

... jorgealejandro.maurino@astrazeneca.com5Neuroscience Area, AstraZeneca Medical Department, Madrid, SpainFull list of author information is available at the end of the articleMontejo et al. Annals ... details1Department of Psychiatry, Hospital Universitario de Salamanca, Salamanca,Spain.2Department of Psychiatry, Hospital del Henares, Coslada, Madrid,Spain.3BAP Health Outcomes Research, Oviedo, ... perspective the most common adverse events of both typical and atypical antipsychotic drugs [4,18].Theaimofthepresentstudywastoevaluatethelin-guistic adaptation and psychometric validation into Span-ish...

Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt

... identified by taking a detailed his-tory and physical examination. The severity of CDH wasdefined from mild instability of the femoral head with slightcapsular laxity, to moderate lateral displacement ... Nishida K, Furuichi T, Toki H, Nishimura G, KawabataH, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S: A noveldominant-negative mutation ... Everman DB, Bartels CF, Yang Y, Yanamandra N, Goodman FR,Mendoza-Londono JR, Savarirayan R, White SM, Graham JM Jr,Gale RP, Svarch E, Newman WG, Kleckers AR, Francomano CA,Govindaiah V, Singh...

Báo cáo y học: "Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study" ppsx

... glycerinatedsaline.Data analysisAn intention-to-treat approach was followed in the ana-lysis of efficacy data. All patients with a baseline and atleast one postrandomization measurement wereincluded in the ... wererepeated. The dose of intranasal or ICS (if used) was maintainedunchanged during the study. Salbutamol metered-doseinhaler, oral antihistamines and intranasal antihistamineswere used on an “as-needed” ... to the study medication and of mild,moderate or serious severity. Specific immunotherapyAlternaria alternata extract and nAlt a1 were producedby Diater (Madrid, Spain). Raw material containingspores...

Báo cáo y học: "Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies" ppsx

... (a) Intra-assay and interassay variability, (b) linearity, and (c) receiver operating characteristic analysis. The intra-assay and inte-rassay variability, expressed as coefficient of variation ... years as containing dimethylated arginines [34]. The two major catalyzing enzymes of this reaction are the type I and type II protein arginine methyltransferases, whichpreferentially methylate ... perform-ance characteristics of the new anti-SMP test are summa-rized in Fig. 2, including intra-assay and interassayvariability (Fig. 2a) , linearity (Fig. 2b), and ROC analysis,PPV, NPV and efficiency...

Báo cáo y học: "Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population" doc

... radiographs. The extent of OA development was evaluated for each of the 14 joints of each hand separately, in accordance with the grading system of Kellgren and Lawrence [19]. The OA evalu-ation was ... Russian Federation. The extent of osteoarthritis was determined by analyzing plain handradiographs. The outcome of a principal component analysis of osteoarthritis scores of a total of 28 joints ... of articular disorders [16]. In this study, we investigated variants of the ENPP1 gene toanalyze whether they have effects on the development of handOA in a large sample of Caucasian nuclear...

Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx

... study was 39.6 years (standard deviation 11.3 years). The mean age at onset of psoriasis was 26.8 years (standarddeviation 12.1 years) and the mean age at onset of PsA was33.0 years (standard ... Newfoundland PsA patients, 53% were male and theirmean age at onset of the study was 49.7 years. The mean ageat onset of psoriasis was 29.3 years (standard deviation 14.2years) and the mean age at ... onset of PsA was 38.1 years(standard deviation 11.0 years). Of the PsA patients, 60% hadpolyarticular disease, 32% had oligoarticular disease and 7%had an isolated spondyloarthropathy. For the...

Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx

... prepared the manuscript. SK, SA,MW and CB participated in the collection of clinical data and the recruitment of patients into the study. UW and HH partici-pated in the design of the study, statistical ... statistical analysis, interpreta-tion of the results, and writing of the final manuscript.AcknowledgementsWe are grateful to the patients with RA, the control individuals, and the collaborating ... condition.Competing interests The authors declare that they have no competing interests.Authors' contributionsMP designed the study, oversaw all aspects of the laboratorywork, analyzed the data and...

Báo cáo y học: "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity" ppsx

... reported and replicated with rheumatoid arthritis (RA) in Japanesepopulations. The aim of this study was to investigate association of the FCRL3 gene with RA in UK subjects. DNA was availablefrom ... individuals included in the cohortwas not included in the analysis. Of the available samples,genotyping was attempted in 1,600 and was successful in 1,589 in the current study. Of all the controls ... dis-crimination assay as described previously [9]. Duplicate sam-ples and negative controls were included across the plates toensure accuracy of genotyping. In addition, for all the assays,genotyping...

Báo cáo y học: "Association of the microsatellite in the 3'''' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study" ppsx

... Bio-sciences) and analyzed by flow cytometry.Statistical analysisAllele and genotype frequencies and carrier rates were calcu-lated in patients with RA and in controls, and no deviationsfrom Hardy–Weinberg ... (Canary Islands, Spain). The median age at onset of RA was 45 years (interquartile range27 to 63 years) and the median disease duration was 13 years(interquartile range 2 to 24); 74% of the ... variables was analyzed by using a multivariate binarylogistic regression model. The final model included DR4,24CAs and sex as independent variables, and disease as the dependent variable. As can...

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