Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt

... significant association of the 1G- 5A haplotype with radiographic damage. The 1G- 5A haplotype explained the variability of the Ratingen score in the same order of magnitude as the SE. Our data suggest that ... analysis Radiographic damage of hands and feet was assessed by the Ratingen score [28], a modification of the Larsen score. It evaluates 38...

Ngày tải lên: 09/08/2014, 01:23

... jorgealejandro.maurino@astrazeneca.com 5 Neuroscience Area, AstraZeneca Medical Department, Madrid, Spain Full list of author information is available at the end of the article Montejo et al. Annals ... details 1 Department of Psychiatry, Hospital Universitario de Salamanca, Salamanca, Spain. 2 Department of Psychiatry, Hospital del Henares, Coslada, Madrid, Spain. 3 BAP Health Ou...

Ngày tải lên: 09/08/2014, 01:21

... identified by taking a detailed his- tory and physical examination. The severity of CDH was defined from mild instability of the femoral head with slight capsular laxity, to moderate lateral displacement ... Nishida K, Furuichi T, Toki H, Nishimura G, Kawabata H, Yokoyama H, Yoshida A, Tominaga S, Nagano J, Shimizu A, Wakana S, Gondo Y, Noda T, Shiroishi T, Ikegawa S: A no...

Ngày tải lên: 09/08/2014, 13:22

... glycerinated saline. Data analysis An intention-to-treat approach was followed in the ana- lysis of efficacy data. All patients with a baseline and at least one postrandomization measurement were included in the ... were repeated. The dose of intranasal or ICS (if used) was maintained unchanged during the study. Salbutamol metered-dose inhaler, oral antihistamines and...

Ngày tải lên: 08/08/2014, 21:20

... (a) Intra-assay and interassay variability, (b) linearity, and (c) receiver operating characteristic analysis. The intra-assay and inte- rassay variability, expressed as coefficient of variation ... years as containing dimethylated arginines [34]. The two major catalyzing enzymes of this reaction are the type I and type II protein arginine methyltransferases, which preferen...

Ngày tải lên: 09/08/2014, 06:22

... radiographs. The extent of OA development was evaluated for each of the 14 joints of each hand separately, in accordance with the grading system of Kellgren and Lawrence [19]. The OA evalu- ation was ... Russian Federation. The extent of osteoarthritis was determined by analyzing plain hand radiographs. The outcome of a principal component analysis of osteoar...

Ngày tải lên: 09/08/2014, 06:23

... study was 39.6 years (standard deviation 11.3 years). The mean age at onset of psoriasis was 26.8 years (standard deviation 12.1 years) and the mean age at onset of PsA was 33.0 years (standard ... Newfoundland PsA patients, 53% were male and their mean age at onset of the study was 49.7 years. The mean age at onset of psoriasis was 29.3 years (standard deviation 14.2 year...

Ngày tải lên: 09/08/2014, 07:20

... prepared the manuscript. SK, SA, MW and CB participated in the collection of clinical data and the recruitment of patients into the study. UW and HH partici- pated in the design of the study, statistical ... statistical analysis, interpreta- tion of the results, and writing of the final manuscript. Acknowledgements We are grateful to the patients with...

Ngày tải lên: 09/08/2014, 08:22

... reported and replicated with rheumatoid arthritis (RA) in Japanese populations. The aim of this study was to investigate association of the FCRL3 gene with RA in UK subjects. DNA was available from ... individuals included in the cohort was not included in the analysis. Of the available samples, genotyping was attempted in 1,600 and was successful in 1,58...

Ngày tải lên: 09/08/2014, 08:22

... Bio- sciences) and analyzed by flow cytometry. Statistical analysis Allele and genotype frequencies and carrier rates were calcu- lated in patients with RA and in controls, and no deviations from Hardy–Weinberg ... (Canary Islands, Spain). The median age at onset of RA was 45 years (interquartile range 27 to 63 years) and the median disease duration was 13 years (inter...

Ngày tải lên: 09/08/2014, 10:21