Báo cáo y học: "Measuring effectiveness of drugs in observational databanks: promises and perils" pdf

... Food and Drug Administration of the USA has intro- duced a requirement for post-marketing surveillance of newer drugs including biological agents; these are now being pursued by pharmaceutical industry, ... bias in assignment of treatment by a physician. ‘Confounding by indication’ means that certain treatments are preferentially given to sicker patients and certain treatments p...

Ngày tải lên: 09/08/2014, 01:23

... study, Trip10 was only sporadically in the cytosol and perinuclear region of IMR-32 control cells, but was more evenly distributed in the cytosol of CP70 control cells (Figure 3 immunostaining). ... undetectable in MSCs, slightly methy- lated in CP70, moderately methylated in MCF7, MDA- MB-231 and HepG2 cells, but hypermethylated in IMR-32 and U87 cells (Figure 1A right)...

Ngày tải lên: 10/08/2014, 05:21

... baseline creatinine, mechanical ventilation and level of care were asso- ciated with ICU-acquired hypernatraemia. Outcomes of care Length of stay and mortality in the ICU and hospital were increased ... patients and hypernatraemia in 2157 (26%) patients with an incidence density of 3.1 and 7.4 per 100 days of ICU admission, respectively, during 29,142 ICU admission day...

Ngày tải lên: 25/10/2012, 10:31

... ‘mucin-like amino acids, serine, threonine and proline. Serine and threonine are points of O-glycosylation found in the tandem repeat regions of mucins and their ratios can vary with the site of secretion ... solid and cystic areas. The cysts were lined by variable mucosae, including colonic type (Fig. 1a) and respiratory type mucosae (Fig. 1b). Deep to the cyst epithel...

Ngày tải lên: 26/10/2012, 10:03

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7% in heal...

Ngày tải lên: 31/10/2012, 16:49

... costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of therapy although they are now widely used in patients receiving interferon ... factors, specifically G-CSF and erythropoietin, has allowed more aggressive dosing of interferon and ribavirin. [13, 14] Finally, growing experience with antiviral ther...

Ngày tải lên: 31/10/2012, 17:11

... m ds ,andm ss are the intercepts and slopes of the lower and upper baselines of the melting curves, respectively; T is the temperature of interest in Kelvin, a is the molar fraction of strands in ... thermodynamic analysis The differences in hydration between the structured duplex strand and the coiled single strands gives rise to an increase in the heat capacity [27,49–...

Ngày tải lên: 22/02/2014, 07:20

... of the human and mouse PXR ligand binding domains. By modeling the human PXR ligand binding domain we have identified and mutated two polar residues in the puta- tive ligand binding pocket which ... change than the spatially and electrostatically moderate change of a histidine to a glutamine and thereby give additional information into its potential role in ligand binding. We a...

Ngày tải lên: 08/03/2014, 16:20

... Bhattacharyya 2 and Chanchal Das Gupta 1 1 Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India; 2 Indian Institute of Chemical Biology, Kolkata, India Porcine ... spectra depicting its intermediate feature. Binding of hydrophobic probe The large loss of fluorescence intensity and little change in the far-UV CD signal are often seen...

Ngày tải lên: 08/03/2014, 23:20

... indicating that, in the absence of coenzyme M, zinc is probably coordinated by a single sulfur ligand and three oxygen or nitrogen ligands. In the presence of coenzyme M, one (N/O)-ligand was replaced by sulfur, ... distinct changes in the zinc ligands. In the His237 fi Ala and Cys239 fi Ala mutants, coenzyme M also seemed to bind efficiently by ligation to zinc indicating that so...

Ngày tải lên: 17/03/2014, 23:20