Báo cáo y học: "Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin" pdf

... antigen. Autoantibodies directed to citrullinated proteins are highly specific for RA (reviewed in [8]). Besides their high specificity, they share more features with the anti-Sa antibodies. They can ... them in the pathophysiology of RA. Keywords: anticitrullinated protein/peptide antibodies, anti-Sa antibodies, citrullinated vimentin, rheumatoid arthritis, Sa antigen Open Acce...

Ngày tải lên: 09/08/2014, 01:23

... from SF but not PB, potentially by DCs or by T cells or both. In the tissue, as a result of antigen presentation by myeloid DCs or pDCs, key effector cytokines may be produced in perivascular ... plasmacy- toid morphology on electron microscopy, a cell-surface phenotype characterized by expression of the BDCA2 anti- gen, by low levels of costimulatory molecule expression, and by the potential...

Ngày tải lên: 09/08/2014, 06:22

... effectively kill endothelial cells in vitro, and may contribute to endothelial cell injury in coronary plaque [10]. ACS = acute coronary syndrome; CABG = coronary artery bypass graft; CAD = coronary ... Kopecky SL, Frye RL, Goronzy JJ, Weyand CM: T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002, 105:570-575. 11. Martens PB, Goronzy JJ, Schaid D, Weyand...

Ngày tải lên: 09/08/2014, 06:23

... verify the hypothesis that Synoviolin is important for the development of arthritis using Synoviolin- knockout mice; that is, a ‘loss-of-function’ study. Collagen Figure 1 Synoviolin is a RING type ... conducted in Syno- violin heterozygous knockout (syno +/− ) mice. The incidence of arthritis in syno +/− mice (7%) was significantly lower than that in wild-type counterparts (syno +/+ ) (6...

Ngày tải lên: 09/08/2014, 07:20

... course, as determined by latex fixation, by Waaler Rose assay or by laser nephelom- etry. The RF test was performed at least once for all TDT and ASP RA patients. The anti-cyclic citrullinated peptide ... single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phos- phatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 2005, 52:219-224. 19. Ste...

Ngày tải lên: 09/08/2014, 07:20

... Hungary Corresponding author: Gyorgy Nagy, gyorgyngy@gmail.com Published: 3 August 2009 Arthritis Research & Therapy 2009, 11:238 (doi:10.1186/ar2751) This article is online at http:/ /arthritis- research.com/content/11/4/238 © ... Buzás 1 and György Nagy 1,2 1 Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvárad tér 4., Budapest, H-1445, Hungary 2 Department...

Ngày tải lên: 09/08/2014, 14:22

... El-Gabalawy HS: Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res 2000, 2:236-243. 8. Bas S, Genevay S, Meyer O, Gabay C: Anti-cyclic citrullinated peptide ... occurrence of antibodies directed to CCP (or RFs) leading to the devel- Table 1 Sensitivity and specificity as diagnostic indicators for rheumatoid arthritis for antibo...

Ngày tải lên: 09/08/2014, 01:23

... patients with early rheumatoid arthritis: effect of early treatment – a prospective, controlled study. Arthritis Res Ther 2006, 8:R82. 7. Kim SH, Lee CK, Lee EY, Park SY, Cho YS, Yoo B, Moon HB: Serum ... (12) years and median disease duration of 6 years, were assessed by food frequency questionnaire (FFQ), fatty acid profile in adipose tissue and whole-body dual energy x ray absorptiometr...

Ngày tải lên: 09/08/2014, 13:22

... relatively recently [3]. Rheumatoid cachexia refers to the loss of fat-free mass, predominantly skeletal muscle, that occurs in RA. Loss of body weight does not always occur; in fact, loss of body fat-free ... higher rates of whole-body protein breakdown compared with young and elderly healthy subjects, and, furthermore, protein breakdown is directly associated with TNF-α production by periph...

Ngày tải lên: 09/08/2014, 14:20

... Fethi Ceylan 3 1. Yuzuncu Yil University, Medical Faculty, Department of Physical Medicine Rehabilitation and Rheumatology, Van, Turkey; 2. Yuzuncu Yil University, Medical Faculty, Department ... Biology, Van, Turkey; 3. Yuzuncu Yil University, Medical Faculty, Department of Orthopaedics, Van, Turkey  Corresponding author: Associate Professor Levent Ediz, MD, PhD. Yuzuncu Yil Universi...

Ngày tải lên: 25/10/2012, 11:15