Báo cáo y học: "β Susceptibility to collagen-induced arthritis is modulated by TGFβ responsiveness of T cells" ppt

... Th1 = T helper type 1; TNFα = tumor necrosis factor α. Arthritis Research & Therapy Vol 6 No 2 Schramm et al. Research article Susceptibility to collagen-induced arthritis is modulated by ... in arthritis development [3]. However, little is known about the regu- lation of T cells that leads to the maintenance of immune homeostasis within the joint. Transformi...

Ngày tải lên: 09/08/2014, 01:23

... arthritis and the symptoms had lasted less than 2 years. At the first visit the rheumatologist answered a questionnaire inquiring about the initial symptoms as reported by the patient (type of ... promptly treated with either methotrexate or salazopyrine (early treatment). The rheumatologists that treated the patients were not aware of the anti-CCP status of their patients because a...

Ngày tải lên: 09/08/2014, 06:23

... to worry about criticism. It is important to emphasise that the MET service is ‘hospital policy’ and that no hospital staff should be reprimanded for calling the MET. Similarly, it is vital to ... improvement in the care of control patients, with doctors and nurses imitating the intervention being studied. It is also unethical to randomly assign acutely ill patients, as it w...

Ngày tải lên: 25/10/2012, 10:35

... low. Introduction Rheumatoid arthritis (RA) is a chronic, autoimmune, inflamma- tory disorder of unknown aetiology that is characterized by symmetric synovitis and the propensity to cause joint destruc- tion, ... Kleinheksel SM, Cathey MA: The mortality of rheumatoid arthritis. Arthritis Rheum 1994, 37:481-494. 5. Emery P: Early rheumatoid arthritis: therapeutic strategies....

Ngày tải lên: 09/08/2014, 07:20

... Furthermore, and with respect to previously expressed circumspection [10], it is diligent to note that while proteolysis of SLRPs in articular cartilage may yield tenable markers of arthritis ... shown to degrade biglycan and fibromodulin (and to a lesser extent decorin and lumican) in cartilage extracts; however, it is important to appreciate that the proteolytic suscepti...

Ngày tải lên: 09/08/2014, 07:20

... follow-up visits and by stand- ardized telephone interviews. Statistical analysis was done by χ 2 test and linear multiple discriminant analysis for categorial data and by t- tests for quantitative ... Germany 2 Department of Dermatology and Venereology, University of Rostock, Augustenstr, 18055 Rostock, Germany 3 Department of Pediatrics, Section of Pediatric Rheumatology and...

Ngày tải lên: 09/08/2014, 10:20

... differ between polyarthritis and oligoarthritis patients (P > 0.46). MBL association with disease parameters Polyarthritis group In the 67 patients with polyarthritis, patients in the low MBL2 genotype ... NS Cumulative affected joints 3 (2 to 6) 4 (2 to 6) 2 (2 to 4) NS NS Actively involved joints 0 (0 to 1) 0 (0 to 1) 0 (0 to 0) NS NS Affected joints 1 (0 to 3) 1 (0 to 2)...

Ngày tải lên: 09/08/2014, 10:23

... qualitatively fewer Th2 Kong et al, Chitosan Interferon-c Nanogene Therapy for Lung Disease 99 be partially inactivated by CIN treatment, and their capacity to activate T cells may consequently ... lungs determined by TUNEL assay and measured by flow cytometry. The data are based on cytometry of a minimum of 15,000 cells and were substantiated by a repeat experiment. 100 Aller...

Ngày tải lên: 08/08/2014, 21:20

... their specific target substrates and limit the extent of proteolysis to discrete pericellular regions [6]. These mechanisms are impor- tant for regulating proteolytic activity. In osteoarthritis (OA), ... biology. The combination of the cytokines IL-1 and oncostatin M (OSM) added to cartilage explant cultures synergistically induces the synthesis and activation of proMMPs, leading...

Ngày tải lên: 09/08/2014, 07:20

... consequence of impaired Th2 differentiation [12]. The nature of a T cell response, namely a Th1 or Th2 response, is modulated by the strength of the MHC–TCR contact, the nature of the co-stimulatory signals, and ... proinflammatory cytokine tumor necrosis factor (TNF) more than 10 years ago, huge efforts have been made to develop inhibitors of p38 MAPK with the intent to...

Ngày tải lên: 09/08/2014, 07:20