Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc

... of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF- κ B- and PI3-kinase/Akt-dependent pathways Sue-Yun Hwang 1 , Ju-Young Kim 1 , Kyoung-Woon Kim 1 , Mi-Kyung Park 1 , Youngmee ... signaling in human monocyte cell line [10] and embryonic fibroblasts [11], respectively, and yet cytoplasmic players transmitting IL-17-mediated activation in R...

Ngày tải lên: 09/08/2014, 01:23

... and the intra-assay and inter-assay coefficient of variation is <5%. The assay is not influenced by rheuma- toid factors. The serum concentrations of COMP obtained by this assay are highly ... destructive mechanisms in arthritis. Semin Arthritis Rheum 2001, 30:7-16. 3. Feldmann M, Maini RN: Discovery of TNF-alpha as a therapeu- tic target in rheumatoid arthritis: precli...

Ngày tải lên: 09/08/2014, 01:21

... fragments of a mono- clonal antibody directed against a specific target fused to a cytokine, thus retaining the functions of both the antibody and the cytokine. In cancer, the use of single-chain antibody fragments ... extra-domain A (EDA) of fibronectin, with the anti-inflammatory cytokine IL-10. They showed the accumulation of this fusion protein at the site of inflammation,...

Ngày tải lên: 09/08/2014, 14:22

... bone marrow cavity in chronic inflammatory arthritis. Introduction TNF is a clinically validated etiological factor in inflammatory- erosive arthritis and is known to synergize with RANKL and macrophage ... in inflammatory osteolysis. Arthritis Res Ther 2006, 8:201. 2. Boyce BF, Schwarz EM, Xing L: Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory b...

Ngày tải lên: 09/08/2014, 10:23

... primary and hospital care. The ultimate clinical utility of a biomarker is defined by the degree it improves clinical decision making and adds timely information beyond that of readily available information ... Muensterlingen, Aarau and Lucerne, respectively, the Swiss Society for Internal Medicine (SGIM), and from the Department of Endocrinology, Diabetology and Clinical Nu...

Ngày tải lên: 25/10/2012, 10:02

... distinct career pathway. Involving such physicians in medical emergency teams will likely facilitate the dual roles of these as a clinical outreach arm of the intensive care unit and in identifying problems ... the study consisted of only a 5-minute debriefing to fill out the standardized MET form on each patient and a weekly 1-hour Commentary The evolving story of medical eme...

Ngày tải lên: 25/10/2012, 10:06

... were residues Gly261 and Gly262. The replacement of Gly262 by Ala resulted in an inactive enzyme. Substitution of Gly261 by Ala resulted to an enzyme with lower stability and increased energy of activation. ... Bouriotis 1,2 1 Department of Biology, Division of Applied Biology and Biotechnology, University of Crete, Greece; 2 Institute of Molecular Biology and Biotechn...

Ngày tải lên: 22/02/2014, 04:20

... SDS/polyacrylamide gel and stained with Coomassie Blue. In vitro kinase assay In this study, mainly two types of in vitro kinase assay were performed. First, we examined whether MAPK phosphory- lates ... noteworthy that these B-type cyclins are strictly regulated in terms of protein amounts during cell cycling by transcription and ubiquitin-mediated proteolysis [11]. Second, t...

Ngày tải lên: 17/03/2014, 23:20

... anti-inflammatory drugs; RF, rheumatoid factor; SF, synovial fluid; TCHA, intra-articularly injected crystalline glucosteroids; VP1, viral protein 1; VP2, viral protein 2. been shown in synovial ... capsid proteins in lymphocytic cells in synovial tissue of autoimmune chronic arthritis. Mod Pathol 2003, 16:811-817. 16. Gurmin V, Rustin MH, Beynon HL: Psoriasis: response to h...

Ngày tải lên: 09/08/2014, 01:23

... values) 0 50 100 150 200 250 Day 8 Day 29 *** * Figure 4 Histological findings in synovial tissue and articular cartilage:Histological findings in synovial tissue and articular cartilage: haematox- ylin and eosin (HE) staining ... significantly affect the proteoglycan con- tent in any layer of the articular cartilage. Figure 3 Safranin O staining intensity in the epiphysea...

Ngày tải lên: 09/08/2014, 06:22