Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regul

Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps

... Furthermore, the subsequent emergence of the Th1–Th2 paradigm seemed largely able to subsume suppression phenom- ena by the patterns of regulatory cytokines that these cells could secrete, and the ... isolating the T lymphocyte fraction that harboured regulatory activity. Sakaguchi and col- leagues managed to first identify the CD5 molecule as a marker for T R c...

Ngày tải lên : 09/08/2014, 01:23

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Tài liệu Báo cáo khoa học: A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid inBordetellasp. strain 10d doc

... properties of the puriﬁed enzyme The activity of the enzyme present in the crude extract of strain 10d that used 2 -amino-5-carboxymuconic 6-semi- aldehyde as substrate was measured by monitoring the increase ... reference. The insets show (A) the ﬂuorescence excitation spe ctrum (detect ed at 530 nm) and ( B) the emission spe ctrum (excited at 450 n m) of the supe...

Ngày tải lên : 19/02/2014, 16:20

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Báo cáo khoa học: A novel metallobridged bis(b-cyclodextrin)s ﬂuorescent probe for the determination of glutathione doc

... added. The mixture was stirred for 24 h at 70 °C under nitrogen. It was then allowed to stand for 5 h until no further precipitate was deposited. The precipitate was removed by ﬁltration, and the ... shaken thoroughly and equilibrated at room temperature for 10 min. The ﬂuorescence intensity of the solution was measured at 365 ⁄ 480 nm. The GSH content of the plasma was...

Ngày tải lên : 07/03/2014, 05:20

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Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx

... increased tPA binding to the cells, whereas the peptide competitively suppressed tPA binding to the matrilysin-treated cells (Figs 7C and 8A). All these results support the hypoth- esis that the N-terminal ... Ac-STVHEILCK at 0.2 mm had no effect on the nontreated cells, it signiﬁcantly inhibited tPA binding to the CaR-1 cells pretreated with matrilysin. These results st...

Ngày tải lên : 17/03/2014, 17:20

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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps

... What exactly is the role of the ordered epitope in initiating spreading, and how might it contribute to the activa- tion of the pool of self-reactive progenitor B cells potentially targeted to ... compartmentalization of the antigen and specific proteolysis of the protein. The most extensive analysis [37] suggests that at least 50% of TEPITOPES predictions are...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus" pps

... pDCs in the human system. Interestingly, the length of the palindrome correlates well with the ability of these ODNs to activate pDCs but not B cells [76-78]. Even though stimulation with microbial ... discuss recent evidence that suggests a role for TLRs in the pathogenesis of systemic autoimmunity. Do Toll-like receptors contribute to systemic autoimmunity? Infections freq...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "A cell-cycle independent role for p21 in regulating synovial fibroblast migration in rheumatoid arthritis" pps

... significantly reduce migration of these cells, suggesting that the loss of p21 in FLS may enhance their ability to migrate towards the proinflammatory constituents of the RA joint. Recently, Besson and ... number of WT and p21 (-/-) FLS in the presence and absence of MMC at the end of the assay and compared it with the number of cells plated at the...

Ngày tải lên : 09/08/2014, 08:22

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Báo cáo y học: " High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease." docx

... functional interplay between Mac-1 and RAGE [26]. Thus, HMGB1 may act synergistically with other immunostimulatory molecules to modulate their interaction with cells and amplify their activity ... construct on the function of HMGB1, the important issue is not the contribution of any possible ‘contamination’ of purified HMGB1 in in vitro experiments but rather the actual fu...

Ngày tải lên : 09/08/2014, 10:23

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báo cáo khoa học: "A cytogenetic survey was carried out on fattening male and female pigs of different lines in a local herd and on " ppsx

... animals. All the carriers in this study were phenotypically normal, and no abnormality was observed on the condition of their health. To evaluate the potential effects of the 13/17 Robertsonian ... lack of information about the family connections of the fattening pigs analysed and with the aim of verifying the estimate of frequen...

Ngày tải lên : 09/08/2014, 22:22

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Báo cáo y học: " Non infective severe aortic paravalvular leakage 7 years after surgery: the role of suture technique" pot

... confirmed a partial prosthesis detachment at the level of the non coronary aortic sinus, due to the semicontinuous suture breaking (Figure 2). The other two sutures of the left and right coronary sinuses ... 2-0 Ethibond (Ethicon) polytetr a- fluoroethylene (Teflon)-buttressed stitches. The Teflon buttresses were positioned in the ventricular aspect of the annulus. Th...

Ngày tải lên : 10/08/2014, 09:21

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