Báo cáo y học: "Giantin is the major Golgi autoantigen in human anti-Golgi complex sera" pptx

... from the Golgi membrane into the cytoplasm. Our working hypothesis is that aberrantly expressed Golgi complex autoantigens may be released into the immune system when cells undergo lysis. By virtue ... prominent function in the processing, transport- ing, and sorting of intracellular proteins subsequent to their synthesis in the rough endoplasmic reticulum. Struc- turall...

Ngày tải lên: 09/08/2014, 01:23

... However, this is the first study in this area. Our findings raise issues for the planning of studies and ethi- cal issues related to the obligation of the physician-researcher to study participants ... Technicians trained in the measurement and scoring of structural change read the MRI scans: they are not usually trained in musculoskeletal radiology or MRI beyond the mea...

Ngày tải lên: 09/08/2014, 10:22

... After 6 weeks the patients attended the clinic again and it is the lipid values and biometric data obtained at this visit which were used for statistical analysis in this study. The presence ... detected by silver staining on polyacrylamid gel. Statistical Analysis Allele frequencies were determined by gene counting and compared using the א² test. The data was analysed...

Ngày tải lên: 31/10/2012, 17:03

... decrease in the activity for the 11b-hydroxylase, CYP11B1. Intriguingly, however, the 11b-hydroxylase activity of the aldosterone synthase CYP11B2 was basically unaffected whereas the 18-hydroxy- lation ... the major mineralocorticoid by means of an 11b-hydroxylation and an 18-hydroxylation/oxidation of 11-deoxycorticosterone. Thus, the proteins of the CYP11B subfamily cat...

Ngày tải lên: 22/02/2014, 07:20

... evidence, there is limited scope for the use of topiramate in acute mania. The only randomised single blind study by McIntyre et al. [88], in the treatment of refractory bipolar disorders in depressive ... of topiramate in the treatment of alcohol dependence is based on reversing chronic changes induced by alcohol resulting in dopamine-facilitated neurotransmission in...

Ngày tải lên: 08/08/2014, 21:20

... fundamental roles in the pathogenesis of autoimmune diseases. Consequently, therapeutic targeting of B cells is gaining prominence in our clinical armamentarium for an ever expanding array of autoimmune ... for autoantigens may be at the core of the pathogenesis of SLE and RA and perhaps of other autoimmune diseases. As is always the case with disease, the ultimate goal is...

Ngày tải lên: 09/08/2014, 07:20

... increase in Cyp7b activity We further investigated a putative role for MAPKs in the TNF- α-induced increase in Cyp7b activity by using the MEK1 inhib- itor PD98059 and the p38 inhibitor SB203580. The ... TNF-α-induced increase in Cyp7b activity. The absence of an effect of the MAPK inhibitors PD98059 and SB203580 on TNF-α-induced Cyp7b activity is in accordance with o...

Ngày tải lên: 09/08/2014, 07:20

... potential in inflammatory diseases, including rheumatoid arthritis (RA) and multiple sclerosis. The aim of this study was to determine whether the key elements of the endocannabinoid signalling system, ... this grading system are presented in Figure 1. Quantification of inflammatory cytokines in synovial fluid Cytokine profiles in synovial fluid were determined using a BD™ cyto...

Ngày tải lên: 09/08/2014, 10:23

... comparison of the different packaging systems is necessary to determine the suitability of different packaging systems for specific therapeutic applications. It was previously hypothesized that the ... decreasing recombination fre- quency between components of packaging systems is by using hybrid packaging systems consisting of helper and gene transfer constructs derived in their...

Ngày tải lên: 10/08/2014, 05:21

... stimulation therapy for human immunodeficiency virus type 1 reservoirs in infected persons receiving virally suppressive highly active antiretroviral therapy. The Journal of infectious diseases 2002, 186:1403-1411. 30. ... substantially improved the prognosis for HIV-infected patients, it does not cure the infection. Replication-competent HIV-1 per- sists in a stable, latent reser...

Ngày tải lên: 10/08/2014, 05:21