Báo cáo y học: "Natural killer cells and autoimmunity" doc
Báo cáo y học: "Natural killer cells and autoimmunity" doc
... immune system,
and in particular NK cells, influence subsequent adaptive
immune responses. By virtue of their ability to rapidly kill
abnormal cells and produce cytokines and chemokines,
NK cells ... natural cyto-
toxicity receptor family (Nkp30, Nkp44 and Nkp46;
reviewed in [1,10–13]).
Although NK cells are prepared to kill abnormal cells and
rapidly release cytokines, the...
Báo cáo y học: "Natural killer T cells and rheumatoid arthritis: friend or foe" ppt
... Res 2002, 8:3702-3709.
11. Miyamoto K, Miyake S, Yamamura T: A synthetic glycolipid pre-
vents autoimmune encephalomyelitis by inducing TH2 bias of
natural killer T cells. Nature 2001, 413(6855):531-534.
12. ... synovial inflammation by residing in a niche
where they are usually absent. Hence, Vαi NKT cells were
reported to appear within the synovium of wild-type mice
as early as three d...
Báo cáo y học: "Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome" pot
... analysis of perforin expression in NK cells and cyto-toxic CD8
+
cellsFlow cytometric analysis of perforin expression in NK cells and cyto-
toxic CD8
+
cells. (a) Normal control: 95% of NK cells ... [TCR]-αβ
-
), NK T cells (CD56
+
/TCR-αβ
+
), and CD8
+
T
cells were also assessed for perforin and granzyme B
expression by flow cytometry. Overall, NK cytolytic activity was...
Báo cáo y học: "Leukotrienes, mast cells, and T cells" docx
... CD8
T cells are widely distributed throughout the synovial mem-
brane and in synovial fluid, exhibit an activated phenotype
and enhanced migratory activity, express proinflammatory
cytokines, and ... mast cells and T cells [9].
Using a transwell migration assay, Ott and colleagues
observed that murine CD8 Teff cells but not Tcm cells
migrated in response to soluble factor(...
Báo cáo hóa học: "Lasers, stem cells, and COPD" docx
... immu-
nological cells. High intensity He-Ne irradiation at 28
and 112 J/cm
2
of human peripheral blood mononuclear
cells, a heterogeneou s population of T cells, B cells, NK
cells, and monocytes has ... [7], and auto-anti-
body production [8]. Mesenchymal stem cells have been
demonstrated to potently suppress autoreactive T cells
[9,10], inhibit macrophage activation [11], and...
Báo cáo y học: "Natural History and Clinical Consequences of Hepatitis B Virus Infection"
... primarily in North America, Northern Europe, India, and Africa. Genotype B and C are common in
Asia; genotype D, in southern Europe, the Middle East, and India; genotype E, in West Africa and South ... over the years in
understanding the behavior and clinical course of the disease; however, the
natural history of HBV is complex and we still have much to explore and
learn.
K...
Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... antibody was
used as a secondary antibody. The antibody-reactive bands
were revealed by ECL-based detection (Amersham Phar-
macia Biotech).
Statistical analysis
Data were analyzed by analysis of ... MTT,
3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide;
PARP, poly(ADP-ribose) polymerase; Py, pyrithione; TPEN,
N,N,N¢,N¢-tetrakis-(2-pyridylmethyl)ethylenediamine; TUNEL,
terminal...
Báo cáo y học: "Heterogeneity of CD4+ and CD8+ memory T cells in localized and generalized Wegener’s granulomatosis." potx
... memory T cells has been used to denote
memory T cells that display migratory properties, readily
produce cytokines and release granular contents [6–8].
These cells show striking tissue selectivity ... Germany). CD4
+
or CD8
+
lym-
phocytes were gated for analysis based on light scattering
properties and on CD4 or CD8 and CD45 staining. Data
were collected for 10
4
lymphocytes. Pos...
Báo cáo y học: "Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28– T cells in ankylosing spondylitis" ppt
... perforin, and thus they must be considered
proinflammatory and cytotoxic. These T cells share
phenotypic and functional properties of natural killer cells,
strongly expressing CD57 but lacking the lymphocyte ... and much work has
concentrated on characterizing B27 restricted cytotoxic
T lymphocytes in spondyloarthropathy patients [3,4]. CD8
+
cytotoxic T lymphocytes identified b...
Báo cáo y học: "VLA-4-dependent and -independent pathways in cell contactinduced proinflammatory cytokine production by synovial nurselike cells from rheumatoid arthritis patients" potx
... enhanced
proinflammatory cytokine production by the RA-SNC77
cells.
Discussion
RA is characterized by chronic infiltration of T lymphocytes
and B lymphocytes, plasma cells, and macrophages into
the synovial ... contribution of lymphocyte binding and subsequent
transmigration to the accelerated proinflammatory cytokine
production by the RA-SNC77 cells, and show that
lymphocyte bind...