Báo cáo y học: "Evidence for early disease-modifying drugs in rheumatoid arthritis" pps

... representing potential therapeutic targets. For example, blockade of surface lymphotoxin using a decoy lymphotoxin receptor- immunoglobulin and BAFF, as discussed below, are currently in clinical ... the lymphoid-like structures and to a reduction in T-helper (Th)1 interferon-γ producing cells, which are known to be involved in the induction and maintenance of the proinflammatory cyto...

Ngày tải lên: 09/08/2014, 10:20

... antigen presentation in monocytes and inhibits the production of pro- inflammatory cytokines, GM-CSF, and Fc-γ receptors by synovial Mφ. Consistently with cytokine and chemokine downregulation, IL-10 clearly suppresses ... not for citation purposes) Table 4 Overview of pro-inflammatory interleukins relevant to macrophage (dys)function in rheumatoid arthritis Family Cytokine Pro-inflam...

Ngày tải lên: 09/08/2014, 10:22

... anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilageDetection of anti-glycosaminoglycan (GAG) antibody binding to the extracellular matrix of hyaline cartilage. ... expressed by E. coli [38]. Therefore it is very likely that carbohydrate neoepitopes are generated in vivo locally by the activity of these glycosidases during infections. An increasing...

Ngày tải lên: 09/08/2014, 13:22

... DMARD such as hydroxychloroquine in limiting the X-ray progres- sion in early RA [6]. Benefits from early DMARD therapy extend over 5 years. Borg and colleagues [7] compared early treatment with ... 9-month RCT of hydrox- ychloroquine versus placebo in early RA. Three years after the study ended, early DMARD therapy still resulted in less pain and disability. The report by V...

Ngày tải lên: 09/08/2014, 01:23

... including conformance with Hardy-Wein- berg equilibrium, linkage disequilibrium, and haplotype fre- quency estimation, were performed using Haploview version 3.32 [14]. Conformance with Hardy-Weinberg ... adjusted for gender, education, disease-modifying anti-rheumatic drugs, prednisolone dose, use of biologics, family history, and hemoglobin. a Model was not adjusted for hemoglobin;...

Ngày tải lên: 09/08/2014, 10:20

... of interferons and is induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is induced in RA-SF by ... protein 3; FLICE = Fas-associating protein with death domain [FADD]-like interleukin 1β con- verting enzyme [ICE]; FLIP = FLICE inhibitory protein; HD = high-density; HE = hematoxylin and eosin;...

Ngày tải lên: 09/08/2014, 06:22

... colony-stimulating factor. 281 CFU-M = colony-forming-unit megakaryocyte; COX-2 = cyclooxygenase; ELISA = enzyme-linked immunosorbent assay; GM-CSF = granulocyte–macrophage colony-stimulating ... anti-inflammatory cytokines IL-4 and IL-13 completely inhibited the production of IL-17 in synovial tissues [30]. Lubberts et al. [31] recently reported the IL-4 gene therapy for collagen-induced...

Ngày tải lên: 09/08/2014, 06:22

... functional assay for TNF-α activity was designed using the ability of RA synoviocytes to produce IL-6 and OPG in response to TNF-α [5]. To isolate synoviocytes, RA synovial tissues were finely minced ... clinical response, suggesting that their RA was not much driven by TNF-α activity alone but probably by other cytokines or mechanisms. The heterogeneity in these patterns may be explain...

Ngày tải lên: 09/08/2014, 06:22

... regulatory pathways described for IL-18. High affinity binding by IL-18 binding protein a and c isoforms renders these obvious neutralising agents, and early clinical studies to establish the safety ... function in varied tissue cell lineages including keratinocytes, osteoclasts and chondrocytes [2]. Importantly, IL-18 often acts in synergy rather than independently, and for some ac...

Ngày tải lên: 09/08/2014, 06:22

... ability to bind spe- cific IgG isotypes may therefore play an important role in deter- mining the severity and persistence of inflammation to IgG (auto)antibodies and immune complexes in RA. ... that had not yielded reliable results on direct sequencing [11] were genotyped using our single- stranded conformational polymorphism assay [12] and were included in the haplotype analysis. FCGR...

Ngày tải lên: 09/08/2014, 07:20