Báo cáo y học: "Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols" docx

... article Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti -TNF protocols Eleni Douni 1 , Petros P Sfikakis 2 , Sylva ... efficacy of diacerein in preventing the development of pathology in the Tg197 transgenic murine model of RA, in which inflammatory pol...

Ngày tải lên: 09/08/2014, 01:23

... MU-meta- bolites in the inhibition of HA synthesis by MU in FM100 cells. These above results indicate that something required for a fully functional HA synthesis system is down-regulated or inhibited in intact ... Further study will be required to confirm this interpretation and to understand fully the mechanisms for inhibition of HA synthesis by MU. This information may be use...

Ngày tải lên: 08/03/2014, 09:20

... Ca 2+ ligating amino acids in the N-terminal part of the first EGF-like domain of factor X in uences the amidolytic activity of the intact protein [36]. However, direct interactions between the Gla and serine ... for binding intact factor X and Gla– EGF N (data not shown). Kinetics of membrane binding The kinetics of binding to PL membranes of the zymogen factor X, activated...

Ngày tải lên: 08/03/2014, 23:20

... 3) determination, respectively. The effect of HNE combined with TNF- α was evaluated by incubating osteoblasts with HNE (20 μM) for 30 minutes and subsequently stimulating them with TNF- α (1 ... producing excess bone- resorbing cytokines and prostaglandins[11]. Among the pro- inflammatory mediators, interleukin-6 (IL-6) is a multifunctional cytokine involved in osteoclas...

Ngày tải lên: 09/08/2014, 08:22

... analysis of the protein coding regions was also able to determine that the drug binding sites for sunitinib were intact. Clearly, many other changes have occurred within the tumor that likely ... beta dynein heavy chain 7) (Ciliary dynein heavy chain 7) (Dynein heavy chain-like protein 2) (HDHC2) Recurrence 4 ENSG00000156234 CXCL13- 001 10639 78747983 G A R 56 R H C-X-C motif chemokine .....

Ngày tải lên: 09/08/2014, 20:22

... in a subgroup of patients with RA accompanied by a massive infiltration of inflammatory cells [8]. In addition, STAT-1 expression has been shown in T and B lymphocytes in focal inflammatory infiltrates, ... evalu- ation of arthritis (day 14 of AIA). Hematoxylin-eosin stained knee sec- tions were evaluated blindly by grading of inflammation (infl.; cell exudate o...

Ngày tải lên: 09/08/2014, 07:20

... IA, Quayle AJ, Visintin A, Ingalls RR: Local- ization of TLR2 and MyD88 to Chlamydia trachomatis inclu- sions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular ... defense mechanisms involved not only in tuberculosis but also in ReA [18]. Interestingly, IL-12 was not differentially expressed in our study, possibly accounting for the in...

Ngày tải lên: 09/08/2014, 10:20

... pathway. This is supported by recent findings demonstrating TNF -independent IL-7-driven inflammatory and bone-destructive activity [6,7]. IL-7 is also able to regulate joint pathology by T cell-driven immune ... [9]. In addition, estrogen deficient mice (induced by ovariectomy) are characterized by increased IL-7-driven T cell-dependent bone loss [10]. By giving a first gl...

Ngày tải lên: 09/08/2014, 10:23

... reduced by their corresponding siRNAs (P = 0.002 and 0.0004, respectively). siRNAs of SPARC and Ctgf ameliorated fibrosis in skin and reduced inflammation in lungs induced by bleomycin HE stains of ... samples of both lung and skin were fixed in 4% formalin and embedded in paraffin. Sections of 5 μm were stained either with hematoxylin and eosin (HE) and M...

Ngày tải lên: 12/08/2014, 12:20

... regulated by a variety of chemokines (5). The expression of distinct chemokine receptors on infiltrating cell populations, especially on lymphocytes and eosinophils which are highly implicated in ... other cytokines such as IL-13 are involved in the induction of IgE production in our model (32). We also showed that induction of mRNA expression of pro -inflammatory c...

Ngày tải lên: 12/08/2014, 14:20