Báo cáo y học: "Decreased response to IL-12 and IL-18 of peripheral blood cells in rheumatoid arthritis" doc

... already demonstrated the presence of IL-12 as a contributory factor in inducing the IFN-γ-dominant T-cell cytokine response in joints of patients with long- standing RA [13]. IL-18 is a proinflammatory ... proinflammatory cytokine that plays an important role in the Th1-type immune response through the induction of IFN-γ synthesis in T cells and NK cells, T-cell pro...

Ngày tải lên: 09/08/2014, 01:23

... WHO definition. This phenomenon may be explained by differences in the compo- nents and cut-off values used in the definitions. The WHO is the only definition to include albumin/creatinine ratio ... shown). In addition to the originality of most of the findings, this study has several other strengths. These include the use of all of the existing MetS criteria for the first...

Ngày tải lên: 09/08/2014, 14:22

... could potentially be due to the finding of increased insulin and subsequent decreased blood glu- cose–whichinresponsemaystimulateanincreasein cortisol in an attempt to maintain glucose homeostasis [22]. ... related to feeding, are insulin, testosterone, and cortisol. Insulin has multiple physiological functions, ranging from the stimulation of blood glucoseuptakeintocells[...

Ngày tải lên: 11/08/2014, 23:21

... CD4 + T cells with this phenotype are referred to as Tr1 cells. Table 1 Cytokine expression profiles of the three classes of regulatory T cells Cytokine expressed Th3 cells T regulatory 1 cells ... T R cells are thought to represent a population of T cells that are thymically derived and suppress autoreactive CD4 + T cells. This is supported by the finding that thym...

Ngày tải lên: 09/08/2014, 01:24

... antibody trials. Summary of methods and findings The meta-analysis identified nine trials of the use of infliximab or adalimumab in RA. The authors did not include trials of etanercept because they ... analysis and urges caution in interpreting the results. Introduction The introduction of anti-tumour necrosis factor (TNF) agents and their widespread use, particularly for...

Ngày tải lên: 09/08/2014, 08:22

... pathways implicated in RA pathogenesis, including production of proinflammatory cytokines by s ynovial macrophages, p roliferation of FLSs, production of TNF by mast cells, and proliferation of, and ... synovial lining layer, and mild cartilage destruction without bone erosion; 2 to 4 = increasing degrees of inflammatory cell infil- trates, synovial lining hyperplasia and...

Ngày tải lên: 12/08/2014, 11:23

... strong inducer of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, and IL-8. The expression of this cytokine is highly increased in the rheumatoid synovium and correlated ... innate immune responses [2,3]. This proinflammatory cytokine is a strong inducer of other proinflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-8, and macrophage inflamma...

Ngày tải lên: 12/08/2014, 14:22

... a day for two days. Ovariectomy was performed using a dorsal midline incision and the entrance into the abdominal cavity was made with a small cut in to the muscle half to two-thirds of the way ... urinary CTX-II and Figure 4 Illustrative examples of immunostainigs of CTX-II and PIIANP and in situ hybridisations of type IIA collagen mRNAIllustrative examples of immun...

Ngày tải lên: 09/08/2014, 01:22

... nitric oxide and prostaglandin E 2 were assayed. p38 MAPK inhibitors blunt chondrocyte and cartilage proteoglycan synthesis in response to transforming growth factor beta; responses to insulin-like ... contribute to maintenance of matrix proteins in cytokine-activated and stressed carti- lage. Whether similar effects of p38 MAPK inhibitors on chondrocyte responses to c...

Ngày tải lên: 09/08/2014, 01:23

... to 3 years [5,6]. Our study is the first to examine the clinical response to discontinuation of long-term infliximab therapy Table 1 Clinical and laboratory findings for 42 patients with ankylosing ... Monitoring and investigation of the patients, study coordination. MR: Monitoring and investigation of the patients, study coordination. JS: Investigator, writing of the ma...

Ngày tải lên: 09/08/2014, 06:22