Báo cáo y học: "Leukotrienes, mast cells, and T cells" docx

... per- tussis toxin inhibited migration further, implicating BLT1 via activation of G i -type G proteins. Together, these data strongly suggest that a novel function of tissue-activated mast cells ... exhibit an activated phenotype and enhanced migratory activity, express proinflammatory cytokines, and contribute to formation of ectopic germinal centres in synovial tissues [1,6,7]. Recrui...

Ngày tải lên: 09/08/2014, 01:23

... against pathogens [25,26], their physiological function is not just to prevent autoimmunity but also to control the extent of inflammatory reactions in order to prevent tissue damage to the host. ... mBSA clearly demonstrates that their suppressive effect is not strictly limited to autoreactive T cells. Taking into consider- ation that T reg cells are also critically involved in the cont...

Ngày tải lên: 09/08/2014, 06:22

... [28] may con- tribute to this relatively enhanced peripheral Th2 activity in RA patients compared to healthy controls. The reduced capacity of Th2 cells to migrate to the arthritic sites could subsequently ... patients than for healthy controls. Although we show that IL-7, and in particular the combina- tion of IL-7 and IL-4, increased Th2 activity rather than Th1 activity of naive CD4 +...

Ngày tải lên: 09/08/2014, 01:23

... principal osteoclast inhibitor in response to IL-12 treatment. IL-12 and IL-18 act synergistically upon T lymphocytes to inhibit osteoclast formation and when administered together at synergistically low ... expressed on the T cell surface. In addition to interleukins that effect osteoclast formation and activity, estrogen and transforming growth factor (TGF)-β also act through T...

Ngày tải lên: 09/08/2014, 10:20

... viremia. The 23 ART-treated patients were on treatment for 2 or more years. Twenty ART- treated subjects had undetectable viral load, whereas sub- jects ART12, ART11 and ART23 had 36600, 3362 and 13965 ... undetectable in a group of 4 ART- treated patients with a previous history as NP (Table 1 and Materials and Methods), suggesting that this cell population is absent when patients lo...

Ngày tải lên: 10/08/2014, 05:21

... were detectable in the joints 12 days after the adoptive transfer of spleen cells. However, at Abstract T- helper (Th) lymphocytes contribute to arthritis pathogenesis by helping B cells to produce ... whether the recipients received FTY720 or not.  e number of T cells in the secondary lymphatic organs and the titers of IgG1 antibodies against proteo glycan were similar in the FTY7...

Ngày tải lên: 12/08/2014, 12:20

... SLE patients and control subjects were examined by flow cytometry. Twenty-nine SLE patients and 10 control subjects were recruited in this study. Patients were divided into active and inactive groups ... out the analysis by flow cytometry. YA, NH and JW evaluated patients’ data. TP and NH drafted the manuscript. All authors read and approved the final manuscript. Competing interes...

Ngày tải lên: 12/08/2014, 15:22

... Py/Zn treatment. After 6 h of treatment of Zn at the indicated concentration with or without Py, the number of necrotic and apoptotic cells were determined by trypan blue staining and TUNEL assay, ... levels to a level about twofold greater than that of the vehicle-treated control. The intracellular Cu level was also increased by Py/Zn treatment. Although Py treatment alone, but not Zn tr...

Ngày tải lên: 23/03/2014, 21:20

... majority of patients with generalized WG [1,2]. Whereas granulo- matous lesions express predominantly T helper type 1 (Th1)-type cytokines in localized WG [3], a shift towards stronger Th2-type cytokine ... light scattering properties and on CD4 or CD8 and CD45 staining. Data were collected for 10 4 lymphocytes. Positively and nega- tively stained populations were calculated by quadra...

Ngày tải lên: 09/08/2014, 01:21

... peptides to CD8 + T lymphocytes in the pres- ence of β 2 -microglobulin [1,2], and much work has concentrated on characterizing B27 restricted cytotoxic T lymphocytes in spondyloarthropathy patients ... spondylitis, CD28 molecule, CD4 + T cells, cytotoxicity, HLA-B27 Open Access Available online http://arthritis-research.com/content/5/5/R292 R293 thought to contribute to the pathoge...

Ngày tải lên: 09/08/2014, 01:23