Báo cáo y học: " Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis" doc
Báo cáo y học: " Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis" doc
... explain the balance between
proinflammatory and anti-inflammatory cascade. Our study
is the first to show an increase in endorphin and ACTH
concentrations during intramuscular electroporation gene
therapy.
In ... of electroporation, we
developed a new strategy to achieve the transfer of the
gene encoding the intramuscular ‘pain-killer’ POMC in
vivo and determined t...
Báo cáo y học: "Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride" ppsx
... the
intensity of the seizures resulting in reductions in the mild
seizures but a fivefold and twofold increase, respectively,
in the moderate seizures (Table 1).
There were no deaths in the study. ... study, also in normal
healthy human volunteers, examined the effect of admin-
istration of oral bupropion HCl 100 mg followed by the
administration of ethanol found no ch...
Báo cáo y học: "Successful immunotherapy with matrix metalloproteinasederived peptides in adjuvant arthritis depends on the timing of peptide administration" pdf
... purposes)
reduced the clinical signs of AA. The clinical findings were
consistent with the observed changes in bodyweight (see
Supplementary material).
Nasal peptide administration after AA induction
Furthermore, ... nasally with MMP peptides prior to or after AA
induction. Administration of the MMP-10 or the MMP-16
peptide prior to AA induction reduced the arthritic symptom...
Báo cáo y học: " Local treatment with the selective IκB kinase β inhibitor NEMO-binding domain peptide ameliorates synovial inflammation" pot
... steroid-based, they selectively block NF-κB activity in the
joint without causing these side effects. In addition, the NBD
peptide inhibits only pro-inflammatory IKK activity [20] and
may therefore ... [clinical study]) anesthetized
with isoflurane. The skin was prepared with ethanol, and NBD
or MUT peptides were injected in the indicated concentrations
anterolaterally into...
Báo cáo y học: "What should be the core outcomes in chronic pain clinical trials" ppt
... [6].
Pain
Although a ubiquitous phenomenon, pain is inherently
subjective. The only way to know about someone’s pain is
by what they say or show by their behavior. There is an
assumption that pain ... from
academia, the Food and Drug Administration, the National
Institutes of Health, the US Veterans Administration, and
industry. The participants are engaged in research,
clinical,...
Báo cáo y học: "Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression" pdf
... tissues. In contrast, COX-2 is
highly inducible by serum, growth factors, lipopolysaccha-
rides, and cytokines, especially interleukin-1 (IL-1), in cer-
tain cell types involved in inflammatory processes, ... whereas
interleukin-1β, a COX-2 inducer, strongly increased diosgenin-
induced apoptosis of these synoviocytes. These findings
suggest that the proapoptotic effect of diosgenin i...
Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
... response in multiple sclerosis and in experi-
mental autoimmune encephalomyelitis (EAE). These myelin
antigens include myelin basic protein, proteolipid protein,
myelin-associated glycoprotein, myelin ... overlapping peptides derived from several
of these proteins.
‘Myelin proteome’ arrays
Our ‘myelin proteome’ arrays contain 500 proteins and
peptides derived from the myelin sheath, th...
Báo cáo y học: "Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure" potx
... homogeneity of the cellular
reaction in the upper subsynovial layer and the sampling
potential of the US-guided biopsy, the proximal 600 μm of
synovial sublining immediately adjacent to the lining ... the
degree of inflammation and the phenotypic characterization of
infiltrating cell subsets [1,2]. Of the cell types found in the syn-
ovium, the intensity of CD68-posi...
Báo cáo Y học: Formation of aberrant phosphotau fibrillar polymers in neural cultured cells doc
... been found
associated in vivo with NFT [27] and it is able to modify in a
way that results in the in vitro assembly of PHF like filaments
[17]. Interestingly, it has been recently published that lipid
peroxidation ... activated by other ways, such as by oxidative stress
[43,44]. These kinases could play a role in tauopathies such
as Alzheimer’s disease. T he residues modified b y...
Báo cáo Y học: Detailed characterization of polydnavirus immunoevasive proteins in an endoparasitoid wasp doc
... gene
products contains a single EGF-like motif and there is no
other significant amino-acid sequence homology of these
proteins except within the EGF-like motif. Other PDV gene
family containing ... (Fig. 6). These
results clearly demonstrate that the IEP genes do not reside
in the virus genomic DNA but in the wasp chromosomal
DNA. In the light of these data including in...