Báo cáo y học: " Intramuscular electroporation with the pro-opiomelanocortin gene in rat adjuvant arthritis" doc

... explain the balance between proinflammatory and anti-inflammatory cascade. Our study is the first to show an increase in endorphin and ACTH concentrations during intramuscular electroporation gene therapy. In ... of electroporation, we developed a new strategy to achieve the transfer of the gene encoding the intramuscular ‘pain-killer’ POMC in vivo and determined t...

Ngày tải lên: 09/08/2014, 01:23

... the intensity of the seizures resulting in reductions in the mild seizures but a fivefold and twofold increase, respectively, in the moderate seizures (Table 1). There were no deaths in the study. ... study, also in normal healthy human volunteers, examined the effect of admin- istration of oral bupropion HCl 100 mg followed by the administration of ethanol found no ch...

Ngày tải lên: 08/08/2014, 23:20

... purposes) reduced the clinical signs of AA. The clinical findings were consistent with the observed changes in bodyweight (see Supplementary material). Nasal peptide administration after AA induction Furthermore, ... nasally with MMP peptides prior to or after AA induction. Administration of the MMP-10 or the MMP-16 peptide prior to AA induction reduced the arthritic symptom...

Ngày tải lên: 09/08/2014, 03:24

... steroid-based, they selectively block NF-κB activity in the joint without causing these side effects. In addition, the NBD peptide inhibits only pro-inflammatory IKK activity [20] and may therefore ... [clinical study]) anesthetized with isoflurane. The skin was prepared with ethanol, and NBD or MUT peptides were injected in the indicated concentrations anterolaterally into...

Ngày tải lên: 09/08/2014, 08:22

... [6]. Pain Although a ubiquitous phenomenon, pain is inherently subjective. The only way to know about someone’s pain is by what they say or show by their behavior. There is an assumption that pain ... from academia, the Food and Drug Administration, the National Institutes of Health, the US Veterans Administration, and industry. The participants are engaged in research, clinical,...

Ngày tải lên: 09/08/2014, 01:23

... tissues. In contrast, COX-2 is highly inducible by serum, growth factors, lipopolysaccha- rides, and cytokines, especially interleukin-1 (IL-1), in cer- tain cell types involved in inflammatory processes, ... whereas interleukin-1β, a COX-2 inducer, strongly increased diosgenin- induced apoptosis of these synoviocytes. These findings suggest that the proapoptotic effect of diosgenin i...

Ngày tải lên: 09/08/2014, 01:23

... response in multiple sclerosis and in experi- mental autoimmune encephalomyelitis (EAE). These myelin antigens include myelin basic protein, proteolipid protein, myelin-associated glycoprotein, myelin ... overlapping peptides derived from several of these proteins. ‘Myelin proteome’ arrays Our ‘myelin proteome’ arrays contain 500 proteins and peptides derived from the myelin sheath, th...

Ngày tải lên: 09/08/2014, 06:22

... homogeneity of the cellular reaction in the upper subsynovial layer and the sampling potential of the US-guided biopsy, the proximal 600 μm of synovial sublining immediately adjacent to the lining ... the degree of inflammation and the phenotypic characterization of infiltrating cell subsets [1,2]. Of the cell types found in the syn- ovium, the intensity of CD68-posi...

Ngày tải lên: 09/08/2014, 10:21

... been found associated in vivo with NFT [27] and it is able to modify in a way that results in the in vitro assembly of PHF like filaments [17]. Interestingly, it has been recently published that lipid peroxidation ... activated by other ways, such as by oxidative stress [43,44]. These kinases could play a role in tauopathies such as Alzheimer’s disease. T he residues modified b y...

Ngày tải lên: 08/03/2014, 16:20

... gene products contains a single EGF-like motif and there is no other significant amino-acid sequence homology of these proteins except within the EGF-like motif. Other PDV gene family containing ... (Fig. 6). These results clearly demonstrate that the IEP genes do not reside in the virus genomic DNA but in the wasp chromosomal DNA. In the light of these data including in...

Ngày tải lên: 31/03/2014, 15:20