Báo cáo y học: "α Impact of VIP and cAMP on the regulation of TNF-α and IL-10 production: implications for rheumatoid arthritis" pps

... pannus formation, synovial membrane hypertrophy, and mononuclear cell predominance within synovial tissue [7]. The injection of rHMGB1 results in mild to moderate synovitis and may persist for at least ... addition, no correlation was observed between clinical response and the direction of change of HMGB1 expression. The authors concluded that their results reveal an unaff...

Ngày tải lên: 09/08/2014, 10:23

... production of TNF-α and IL-10 by monocytes. Spontaneous production of IL-10 and TNF-α by monocytes could not be detected; cytokine production was induced, however, by addition of LPS (control samples). ... dibutyryl cAMP, forskolin, and VIP were tested for cytotoxicity and displayed no toxi- city at the concentrations being used in this study as determined by (3-[...

Ngày tải lên: 09/08/2014, 01:23

... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAH increases the importance ... a state of progressive chronic organ ischaemia. Dysfunction of cellular components of the arterial wall and dysfunction of inflammatory and haemost...

Ngày tải lên: 09/08/2014, 06:23

... supporting pillars on the bilateral sides of the vessels as they pass the edge of the dural window (the pillars were made of hemostastic sponge wrapped by absorbable thread), and then the superfi- cial ... craniotomy, removal of the in- tracranial lesion, and duraplasty, the bone flap was replaced and one side of the flap was attached to the cranium b...

Ngày tải lên: 25/10/2012, 11:40

... pathogenesis of ankylosing spondylitis? Walter P Maksymowych Department of Medicine, University of Alberta, Edmonton, Alberta T6G 2S2 Canada Corresponding author: Walter P Maksymowych, walter.maksymowych@ualberta.ca See ... anti-TNF therapy does not prevent the development of new syndesmophytes [10]. On the contrary, it appears that new syndesmophytes are even more likely to dev...

Ngày tải lên: 09/08/2014, 01:22

... for by other members of the superfamily. In addition, some ligands may be agonists at one receptor and antagonists at others. Another issue is that one should not interfere with the role played ... is the redundancy of the system, based on in vitro studies. Because one receptor can usually bind multiple ligands and vice versa, one may anticipate that blockade of one liga...

Ngày tải lên: 09/08/2014, 01:23

... activity by gelatine zymography (Figure 4). The 342 FFGVG-G2 and CTX-II peptides are generated by an array of MMPs, of which MMP-2 and MMP-9 are only a subset. On other occasions, the presence of these ... n-telo-peptides of pro-collagen type II under the current culture condition are almost exclusively released during synthesis and thereby may be valid markers for col...

Ngày tải lên: 09/08/2014, 10:23

... quality control program run by the Korean Society of Laboratory Medicine [3]. In 1999 and 2007, reports of antinuclear antibody test using the IT-1 cell line on 208 and 588 systemic lupus erythematosus ... in the pictures they revealed. In addition to the anti- Rib-P that Mahler and colleagues mentioned, limitations of the HEp-2 cell line in the detection of autoan...

Ngày tải lên: 09/08/2014, 14:21

... systematic study is mandatory to compare the sensitivity and specificity of the AIT test for the detection of anti-Rib-P antibodies and other antibody specificities using a variety of contemporary diagnostic ... to the anti-Rib-P system, Bonfa and colleagues clearly demonstrated that immunodiffusion has very low sensitivity for the detection of anti-Rib-P antibodie...

Ngày tải lên: 09/08/2014, 14:22

... conceived and designed the experiments. LFH QYG GFZ YHH performed the experiments. LFH participated in the design of the study and performed the statistical analysis. TTW LFH YYH Wrote the paper. ... Pouyssegur J, Pages G: Implication of the ERK pathway on the post-transcriptional regulation of VEGF mRNA stability. Methods Mol Biol 2010, 661:451-469. 22. Bi S, Li...

Ngày tải lên: 10/08/2014, 05:21