Báo cáo y học: "The role of osteoprotegerin in arthritis" ppsx

... consequently lead to increasing inter- est in the role of osteoclasts in local bone erosion that is driven by the hypothesis that synovial pannus makes use Review The role of osteoprotegerin in arthritis Georg ... Collagen-induced arthritis Species Rat Mouse Rat Dose 1 mg/kg/day 6.4 mg/kg/day 3 mg/kg/day Start Onset of symptoms Onset of symptoms Onset of symptoms Duratio...

Ngày tải lên: 09/08/2014, 01:23

... & Penner-Hahn, J.E. (1998) Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli – the role of zinc in the methylation of homocysteine. J. Am. Chem Soc. 120, 8410–8416. 15. ... to ligation of the thiol group of coenzyme M. Mutations in His237 or Cys239, which are proposed to be involved in ligating zinc, resulted in an over 90...

Ngày tải lên: 17/03/2014, 23:20

... allergy. factors influencing development of the microbiota. Ann Med 1999, 31(4):288-92. 15. Kalliomaki M, Isolauri E: Role of intestinal flora in the develop- ment of allergy. Curr Opin Allergy Clin ... The role of the intestinal microflora for the development of the immune system in early childhood. Eur J Nutr 2002, 41(Suppi 1):I32-7. 18. Penders J, et al.: Molecular finger...

Ngày tải lên: 08/08/2014, 21:20

... an inflammatory challenge by altering production of proinflammatory and anti-inflammatory cytokines and may also affect cytokine signaling by a variety of mechanisms, including induction of SOCS-3 ... whereas in processes involving innate immunity, anti-inflammatory effects of leptin are prevalent. However, it is difficult to elucidate the role, if any, of leptin during inflammat...

Ngày tải lên: 09/08/2014, 08:22

... attempts an intervention, organizational mem- bers may already be conversing in ways that improve sensemaking and learning, or they may be conversing in ways that inhibit sensemaking and learning. The ... greatly in its novelty, ranging from the reinforcement of old beliefs or strengthening existing relationships and power structures to completely innovative ideas existing in the mi...

Ngày tải lên: 11/08/2014, 05:21

... glycosylated proteins of about 50–90 kDa. The single polypeptide chain of a kininogen contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like ... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the...

Ngày tải lên: 17/03/2014, 10:20

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4). The V s /V h r...

Ngày tải lên: 17/03/2014, 23:20

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this ... ternary com- plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to prime substrate oxidation. In the case of DAOCS it has been...

Ngày tải lên: 18/03/2014, 01:20

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing in a...

Ngày tải lên: 09/08/2014, 01:21

... occurs at the β-carbon of the asparagine residue, consequently (by way of steric hindrance) preventing the interaction of the HIF-α C-TAD with the cysteine/histidine-rich 1 domain of p300, a co-activator ... variation in the relative expression of the PHD isoforms in different cells, with PHD-2 being the most abundant HIF prolyl hydroxylase. Specific ‘silencing’ of all three e...

Ngày tải lên: 09/08/2014, 01:22