Báo cáo y học: "The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes" ppt

... evidence of a link in MMP-1 and Bcl-3 expression, and indicate that both molecules are similarly affected by CDDO. CDDO dose–response study in human primary chondrocytes To examine the effects of increasing ... that human primary chondrocytes have low basal expression of MMP-1, MMP-13 and Bcl-3, and that they are increased in the presence of IL-1. Increa...

Ngày tải lên: 09/08/2014, 01:23

... that αMβ2 integrin binds to fibronectin via coordinate interactions with β1 integrins [47,48]. This interaction may involve initial engagement of β1 integrins on neutrophils with a resulting cross-talk signal ... in the salivary glands of rats [2,55], acts as hormonal regulator of integrin-mediated adhesive interactions, or reflects a binding motif on an integrin or an integrin ligand...

Ngày tải lên: 11/08/2014, 08:21

... (1986) The oxidation of primary trimethylsilyl ethers to aldehydes: a selective conversion of a primary hydroxy group into an aldehyde group in the presence of a secondary hydroxy group. J. Prakt. ... the only analogue that inhibits EII Glc by binding to the high- affinity cytoplasmic binding site and also strongly inhibits sugar uptake mediated by this transporter. The most p...

Ngày tải lên: 21/02/2014, 01:21

... showing the DNA binding specificity of RuvA. (A) Binding of wild-type RuvA (2 l M ) and (B) binding of the mutant RuvA (E55R D56K) (1.2 l M ) to Holliday junction, linear duplex and 3-strand junction ... binding and instrument drift. RESULTS Stoichiometry and kinetics of the RuvA–Holliday junction interaction The stoichiometry and kinetics of the RuvA–Holliday junction inte...

Ngày tải lên: 21/02/2014, 01:21

... constitute the main membrane system present in early development of proplastids into chloroplasts. Although d evoid of chlorophyll, they play a r ole in t he initial steps of chlorophyll biosynthesis. ... is discussed. Keywords: protoporphyrin; methyltransferase; chloroplast; membrane; chlorophyll. The chlorophyll molecule is made up of two moieties of distinct origin, c hloroph...

Ngày tải lên: 08/03/2014, 16:20

... stress, intralysosomal Fenton-type reactions become violent enough to jeo- pardize the stability of lysosomal membranes, resulting in leak of a variety of hydrolytic enzymes into the cytosol. Such lysosomal ... lysosomal enzymes, and as lipofuscin- containing lysosomes act as sinks for newly synthesized enzymes, they are not available to functional (lipofuscin-free) lysosomes. The d...

Ngày tải lên: 17/03/2014, 23:20

... that poly(b- L -malate) is active in maintaining mitotic synchrony of plasmodia b y playing the mediator between the periodic synthesis of certain proteins and the catalytic competence of DNA po lymerases. Keywords: ... NA polymerases a, d,andb-like in the nuclea r e xtract, measured in arbitrary units (staining intensity) by the highly sensitive technique o f photoaffinity labe...

Ngày tải lên: 31/03/2014, 21:21

... Helix-II and urinary CTX-II, at time 0 and week 2 in group A, and at time 0, and weeks 4 and 6 of group B. We Figure 2 Measurement of urinary levels of (a) Helix-II and (b) CTX-II in pre- and post-menopausal ... rabbit polyclonal antibody raised against the amino acid 622–632 sequence of the α1 chain of human and rat type II collagen. Intra- and inter-assay v...

Ngày tải lên: 09/08/2014, 01:22

Ngày tải lên: 09/08/2014, 07:20

... regularly (Figure 7), such as road cycling, Nordic walking, cross-country and alpine skiing and swim- ming. One individual returned to playing soccer in a higher league. Physical examination findings Three ... 3 years, 4.75 years and 5.5 years after sur- gery in individuals with an above-average level of sporting activity, such as soccer, tennis and skiing, and therefore with...

Ngày tải lên: 09/08/2014, 10:23