... fluvoxamine binds to sigma-1 receptors in the living human brain at therapeutic doses, suggestingthat sigma-1 receptors might play a role in the mecha-nism of action of fluvoxamine [13]. Given the ... Given the clinical profile of akathisia, it seems that a complex inter-action of several neurotransmitter systems (for example,dopamine, acetylcholine, norepinephrine, serotonin, γ-aminobutyric ... beperformed to clarify the role of sigma-1 receptors in the efficacy of fluvoxamine for akathisia.Furuse and Hashimoto Annals of General Psychiatry 2010, 9:17http://www.annals-general-psychiatry.com/content/9/1/17Open...