Báo cáo y học: "Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis" ppsx

... present study, we have found that this inherent resistance to ReA can be overcome by heavy metal exposure. Mercury exposure alters the cytokine profile, host clearance capability, and histopathological ... (Figure 1b). Figure 2 Histopathology (haematoxylin and eosin) in Chlamydia trachomatis-induced arthritis (CtIA) alone and after a prior exposure to mercuric chloride (HgCl 2 )H...

Ngày tải lên: 09/08/2014, 01:22

... ‘overloading the immune system’ and be able to respond to such fears. One strategy to attend to this concern i s for a clinician to rehearse means to commu- nicate with the patient as to why multiple injections ... cts to vaccine s) “Allergy shots are often called “vaccines” because (1) they are inject ed and (2) the intention of both is to confer immunity.” “ allergy shots...

Ngày tải lên: 08/08/2014, 21:20

... immune systems provide a finely tuned regu- latory system required for health. Disturbances at any level can lead to changes in susceptibility to, and severity of, autoimmune/inflammatory disease. ... proinflammatory stimuli, and severity of inflammatory/autoimmune disease or mortality after removal of these endogenous glucocorti- coids by adrenalectomy or GR blockade. Animal models have e...

Ngày tải lên: 09/08/2014, 01:23

... ligation-induced phosphory- lation of YxxL immunoreceptor tyrosine activation motifs in the cytoplasmic tails of TCRζ and CD3ε, γ and δ chains [12]. By binding to tandemly arranged immunoreceptor tyrosine activation ... repertoire of autoreactive effector T cells that are necessary and sufficient to promote spontaneous inflammatory arthritis. In 2002, investigators from the laboratory of...

Ngày tải lên: 09/08/2014, 01:23

... displaying an immunoregulatory functional attribute of this cytokine. Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by symmetrical joint involvement, synovial ... into the peritoneal cavity following TNFα injection intraperitoneally. Similarly, we also ruled out any TNFα-induced enhancement of the level of mRNA for IDO, the enzyme involved in IDO-tryptop...

Ngày tải lên: 09/08/2014, 10:23

... Worthington J: Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol ... Zama K, Oka T, Juji T, Yamane A, Tokunaga K: Lack of a strong associ- ation of CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Jap...

Ngày tải lên: 09/08/2014, 14:22

... bacteria, yeast and mammals [26], and its toxicity lies in its ability to bind sulfhydryl groups of cysteine residues in proteins, thereby inactivating them. Arsenite is considered to be more toxic ... insertion of any other metal ion than molybdate. Analysis of metal insertion into R. sphaeroides dimethylsulfoxide reductase Most molybdoenzymes in E. coli contain the bis- MGD cofactor...

Ngày tải lên: 23/03/2014, 06:20

... 1 Department of Psychiatry and Ophthalmology, SUNY Downstate Medical Center, New York, NY, 2 Brooklyn Research Foundation on Minority Health, KJMC, New York, NY, 3 Department of Psychiatry, Maimonides ... to sleep duration than to a history of hyper- tension, diabetes, or respiratory disease, BMI, mood or sleep quality. Possibly, sleep duration is a proxy for these measures, as it cor...

Ngày tải lên: 10/08/2014, 09:20

... pro-inflammatory gene expression and may contribute to a chronic enhanced inflammatory response seen in models of cigarette smoke exposure [21,26,27]. Cigarette smoke is the major etiological factor in ... COPD. Cigarette smoke -exposure induces a relatively gluco- corticoid unresponsive inflammatory response in the lungs of mice which is linked to a reduction in HDAC activity and may...

Ngày tải lên: 11/08/2014, 03:20

... 87:139-150. 17. Ito K, Ito M, Elliott WM, Cosio B, Caramori G, Kon OM, Barczyk A, Hayashi S, Adcock IM, Hogg JC, Barnes PJ: Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease. ... HDAC- 2 activity and the expression of mSin3a and Mi-2α in the lungs of smoke exposed mice. This may contribute to the enhanced inflammatory response which is relatively insensitive...

Ngày tải lên: 11/08/2014, 06:22