Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot

... the synovial sublining of BD and PsA, indicating that there is no systematic bias in local inflammation between the two study groups (Figure 1). Further analysis of the synovial leukocyte infiltration ... as important infiltrating cell populations in BD. Increased levels of perforin in BD suggest the relevance of cytotoxicity in this disease. Introduction Behçet disease (B...

Ngày tải lên: 09/08/2014, 01:22

... ligation-induced phosphory- lation of YxxL immunoreceptor tyrosine activation motifs in the cytoplasmic tails of TCRζ and CD3ε, γ and δ chains [12]. By binding to tandemly arranged immunoreceptor tyrosine ... regulatory loop by generating knock -in mouse lines expressing the 75 9Y to F mutation. Commentary Altered signalling thresholds in T lymphocytes cause autoimmune arthritis And...

Ngày tải lên: 09/08/2014, 01:23

... GATA-3. Another interesting and recent finding is that the lack of RUNX3 in a mouse model results in eosinophilic airway inflammation. Interestingly, RUNX3 was found to be expressed in mouse mature ... previously identified by linkage in sibling pairs, and by thorough haplotype analysis narrowed it down to a single polymorphism (having excluded the remaining nine that showed assoc...

Ngày tải lên: 09/08/2014, 01:23

... [3]. In the murine models, preliminary data indicate that similar strains, carrying the Q haplotype, develop disease in the matrilin-1-induced relapsing polychondritis and in the col- lagen-induced ... lymphocytes, macrophages and eosinophils. Hematoxylin and erythrosine staining. Reproduced with the permission of the American Society for Clinical Investigation Inc. 297 Availabl...

Ngày tải lên: 09/08/2014, 06:22

... and microcytotoxicity assays. Preliminary association analysis was conducted by χ 2 test- ing on contingency tables comparing the three genotypic frequencies between cases and control individuals to yield a ... of synovitis may range from minimal to severe, and vary in terms of number of joints involved, with systemic onset disease typically associated with the great- est morbidity...

Ngày tải lên: 09/08/2014, 06:22

... chromatography electrospray ionization tandem mass spectrometry time-of-flight (LC-ESI-MC/MS-TOF) analysis. Over 90 peptide ions were examined and only 2 proteins were identified, including immunoglobulin ... Therapy Vol 7 No 4 Miyamae et al. R753 Some of the difficulties inherent in gene or protein expression profiling in human disease include accounting for the genetic and environ...

Ngày tải lên: 09/08/2014, 06:22

... renal, lung, and cardiac injuries, at least partially by shifting the microenvironment at the injury sites from proinflammatory to anti-inflammatory [55-57]. In a murine pulmonary fibrosis model, MSCs inhibited ... delivered via either adenoviral infection or osmotic pumps in inhibiting bleomycin-induced increases in TNF-α, IL-1α, and trafficking of lymphocytes and neutrophils int...

Ngày tải lên: 09/08/2014, 13:22

... easy for a rare condition such as BD. The authors addressed this point by performing the initial analysis on pooled samples and then, having identified potential SNPs, validating the findings in ... analysis very pre- liminary, but several other SNPs have been linked to ocular disease specifically, so these findings are not unexpected [8]. It should be noted, however, that eye and vas...

Ngày tải lên: 09/08/2014, 14:22

... trigger autoimmunity against myelin. Other compo- nents of myelin including proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) are also known to be capable of eliciting specific ... and asymptomatic mice. Discussion In a mouse model, intravenously inoculated JE virus migrates into the brain within 2 d after inoculation, causing the brain to become infected by the in...

Ngày tải lên: 10/08/2014, 05:21

... pro- tein family and the key proteins in the UPR pathway may, in part, be mediated by their destabilizing effect on UPR proteins and increased accumulation of misfolded proteins. Myeloma cell study ... pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17- demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors. J C...

Ngày tải lên: 10/08/2014, 21:23