Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot
Báo cáo y học: "Distinct synovial immunopathology in Behçet disease and psoriatic arthritis" pot
... the synovial sublining of BD and PsA, indicating that there is nosystematic bias in local inflammation between the two studygroups (Figure 1). Further analysis of the synovial leukocyteinfiltration ... asimportant infiltrating cell populations in BD. Increased levels ofperforin in BD suggest the relevance of cytotoxicity in this disease. Introduction Behçet disease (BD) is a systemic inflammatory disorder ... 1Immunohistochemical analysis of synovial tissue biopsies from early untreated Behçet disease and psoriatic arthritis Behçet disease Psoriatic arthritis P valuen = 8 n = 9 Synovial immunopathology (cells/mm2)CD68...
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Báo cáo y học: "Altered signalling thresholds in T lymphocytes cause autoimmune arthritis." ppsx
... ligation-induced phosphory-lation of YxxL immunoreceptor tyrosine activation motifs in the cytoplasmic tails of TCRζ and CD3ε, γ and δ chains[12]. By binding to tandemly arranged immunoreceptortyrosine ... regulatory loop by generating knock -in mouse lines expressing the 75 9Y to F mutation.CommentaryAltered signalling thresholds in T lymphocytes causeautoimmune arthritisAndrew P CopeKennedy Institute ... and joint destruction that was more severe in females. Although the synovitis was typical of RA with apredominant lymphocytic infiltrate, a systemic inflam-matory disease was also evident in...
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Báo cáo y học: "Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus" pptx
... GATA-3.Another interesting and recent finding is that the lack ofRUNX3 in a mouse model results in eosinophilic airwayinflammation. Interestingly, RUNX3 was found to beexpressed in mouse mature ... previouslyidentified by linkage in sibling pairs, and by thoroughhaplotype analysis narrowed it down to a singlepolymorphism (having excluded the remaining nine thatshowed association out ... pathways and identifysusceptibility genes or susceptibility effects that might beepistatic, additive or independent.Similarly, the psoriasis study analyzed a region previouslyidentified by linkage...
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Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
... [3]. In the murine models, preliminary data indicate that similarstrains, carrying the Q haplotype, develop disease in thematrilin-1-induced relapsing polychondritis and in the col-lagen-induced ... lymphocytes, macrophages and eosinophils. Hematoxylin and erythrosine staining. Reproduced with the permission of the American Society for Clinical Investigation Inc.297Available online http://arthritis-research.com/content/4/5/2961. ... that mimics symp-toms originating in the nose and respiratory tract. Bothmice and rats immunized with matrilin-1 developed inspira-tory distress that appeared in cycles [3]. Symptoms in therodents...
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Báo cáo y học: "Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case–control study" pot
... and microcytotoxicity assays.Preliminary association analysis was conducted by χ2 test-ing on contingency tables comparing the three genotypicfrequencies between cases and control individuals to yielda ... of synovitis may range from minimal tosevere, and vary in terms of number of joints involved, withsystemic onset disease typically associated with the great-est morbidity. JRA is probably a ... heterozygous par-ents to affected individuals. In the absence of one parent,the family becomes uninformative regarding single nucle-otide polymorphisms and cannot be included in the analy-sis....
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Báo cáo y học: "Serum protein profile in systemic-onset juvenile idiopathic arthritis differentiates response versus nonresponse to therapy" ppt
... chromatography electrospray ionization tandem massspectrometry time-of-flight (LC-ESI-MC/MS-TOF) analysis.Over 90 peptide ions were examined and only 2 proteins wereidentified, including immunoglobulin ... Therapy Vol 7 No 4 Miyamae et al.R753Some of the difficulties inherent in gene or protein expressionprofiling in human disease include accounting for the genetic and environmental variability ... biochemical/mass spectrometryanalysis to identify differentially-expressed proteins. A recentstudy using two-dimensional gels and MALDI-TOF MS analy-sis of plasma and synovial fluids from patients...
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Báo cáo y học: "Mesenchymal stem cells in arthritic disease" pot
... renal,lung, and cardiac injuries, at least partially by shifting themicroenvironment at the injury sites from proinflammatory toanti-inflammatory [55-57]. In a murine pulmonary fibrosismodel, MSCs inhibited ... delivered via either adenoviral infection orosmotic pumps in inhibiting bleomycin-induced increases in TNF-α, IL-1α, and trafficking of lymphocytes and neutrophilsinto the lung [56]. These successful ... albeitcontroversially, to differentiate into myocytes and cardio-myocytes and even into cells of nonmesodermal origin,including hepatocytes and neurons [16].MSC chondrogenesis is a complex process and an...
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Báo cáo y học: " Novel genetic analysis in Behçet’s disease" ppsx
... easy for a rare condition such as BD.The authors addressed this point by performing the initialanalysis on pooled samples and then, having identifiedpotential SNPs, validating the findings in ... analysis very pre-liminary, but several other SNPs have been linked to ocular disease specifically, so these findings are not unexpected [8].It should be noted, however, that eye and vascular disease can ... locuspreviously identified in a multiplex family study [2]. UBASH3B and UBAC2 encode ubiquitin-associated proteins. Theubiquitin system is best described in targeting misfolded ordamaged proteins for...
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Báo cáo y học: "Autoimmunity-related demyelination in infection by Japanese encephalitis virus" pot
... trigger autoimmunity against myelin. Other compo-nents of myelin including proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) are alsoknown to be capable of eliciting specific ... and asymptomatic mice.Discussion In a mouse model, intravenously inoculated JE virusmigrates into the brain within 2 d after inoculation,causing the brain to become infected by the invadingvirus ... that demyelination commonly occurs in themouse brain infected by the JE virus. Nevertheless, howdemyelination occurs in brains infected with this virusremains ambiguous. In this study, we provide...
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Báo cáo y học: "Unfolded protein response in cancer: the Physician’s perspective" pot
... pro-tein family and the key proteins in the UPR pathwaymay, in part, be mediated by their destabilizing effect onUPR proteins and increased accumulation of misfoldedproteins.Myeloma cell study ... pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors. J Clin Oncol ... unfolded protein respons e and its effecton tumorigenesisA broad range of cancer-types rely on ER protein fold-ing machinery to correctly fold key signaling pathwayproteins [41]. ER stress and the...
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