Báo cáo y học: "Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration" potx

... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM receptor interaction), ... inhibi- tion prevents proinflammatory cytokine-induced cartilage damage. Rheumatology (Oxford) 2002, 41:801-808. 12. Tak PP: Chemokine inhibition in inflammatory arthritis. Best Prac...

Ngày tải lên: 09/08/2014, 01:22

... adiposity-associated inflammatory factors such as C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α may play a role in promoting adverse vascular outcomes. The intima ... correlated to body weight, body mass index, waist circumference, waist to hip ratio, systolic blood pressure, diastolic blood pressure, fasting insulin, homoeostasis model assessment-...

Ngày tải lên: 25/10/2012, 11:40

... hereditary and environmental factors. The disease is characterized by lymphocytic infiltration and inflam- mation in the salivary and lacrimal glands, leading to oral and ocular dryness. To understand ... Aec2 contain genes that control development of SjS. In the present study, the investigators produced recombinant inbred lines by crossing the C57Bl/6 and C57Bl/6.NOD- Aec1Aec2 strain...

Ngày tải lên: 09/08/2014, 01:22

... bone- resorbing cytokines and prostaglandins[11]. Among the pro- inflammatory mediators, interleukin-6 (IL-6) is a multifunctional cytokine involved in osteoclast recruitment and differentiation into ... but not ERK1/2 To gain insight into the signaling pathway activated by HNE in human OA osteoblasts, we first examined the HNE-induced phosphorylation patterns of MAPKs over increasing...

Ngày tải lên: 09/08/2014, 08:22

... augmented the cytotoxic effect of HNE as determined by MTT assay. In contrast, the overexpression of this enzyme in chondrocytes offered significant protection against HNE-induced cell cyto- toxicity. These ... death in human osteoarthritis chondrocytes To investigate the effect of HNE on chondrocyte apoptosis, we first documented HNE cytotoxicity by MTT assay. After 16 hours of in...

Ngày tải lên: 09/08/2014, 13:21

... by Smad proteinsThe scheme summarises different intracellular pathways during osteoblast differentiation which include promoting (blue) and inhibiting (red) factors and are mainly mediated by ... pressure or on interactions with local leukotrienes and cytokines. From a molecular point of view, the G-protein-coupled prosta- noid IP receptor plays a crucial role in the prostacyclin- induce...

Ngày tải lên: 09/08/2014, 13:22

... Sox9 staining patterns were mainly nuclear in normal cartilage (Figure 2), but Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure 3 Stem cell markers in human ... significantly fell to 19% in the DZ of fibrillated cartilage. In summary, the SZ of non-fibrillated OA cartilage showed reduced Notch-1 and Sox9 staining frequency. Yet, the MZ...

Ngày tải lên: 09/08/2014, 14:21

... enzymes [10]; biotinylation of histones by biotinidase depends on the hydrolytic cleavage of biocytin (biotinyl-e- lysine), coupled to the transfer of the biotinyl residue to free amino groups in ... Effects of arginine dimethylation on the biotinylation of lysine residues in the N-terminal tail in histone H3. Synthetic pep- tides were biotinylated enzymatically, and biotin was prob...

Ngày tải lên: 23/03/2014, 15:20

... recombinant human epider- mal growth factor; PtdIns3-kinase, phosphatidylinositol 3-kinase; b-Gal, b-galactosidase; PVDF, poly(vinylidene di¯uoride); ECL, enhanced chemoluminescence; IL, interleukin. De®nition: ... medium f or up to 6 h, indicating a l onger lasting s ecretion of activator molecules or growth factors. Adding suramin, a potent inhibitor of growth factor receptor±ligand bin...

Ngày tải lên: 17/03/2014, 17:20

... genetics to aid in choosing the most appropriate therapy. As clinicians attempting to stay current in the evolving science of asthma, we must continue to follow the very exciting literature regarding ... regarding potential phenotypic and genotypic indicators of response to therapy because one or the combination of both of these tools will likely be a clue to a patient’s re...

Ngày tải lên: 08/08/2014, 21:20