Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt

... However, the role played by other members of the HIF family in the pathogenesis of SSc has not yet been investigated in detail. Insufficient response to hypoxia: dysregulation of angiogenesis in systemic ... procollagen prolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX) and lysyl hydroxylases (procollagen lysyl hydroxylase and procollagen lysyl hydroxylase 2). Si...

Ngày tải lên: 09/08/2014, 01:22

... surprising considering the components of the ACR criteria. One of the criteria is the presence of erosions on the radiographs of hands and wrists. In the early phases of RA only 13% of the patients ... Additionally, erosions often initially present in the small joints of the feet, and appear in the small joints of the hands at a later point in th...

Ngày tải lên: 09/08/2014, 10:23

... contributors to the pathogenesis of RA. MCs may be considered the immunological sentinel of the syn- ovium, acting immediately in the event of joint trauma by liber- ating an array of proinflammatory mediators. ... to perpetuate the chronic process by their marked increased accumulation in the synovial lining of the inflamed joint and their ability to produce num...

Ngày tải lên: 09/08/2014, 14:22

... Research & Therapy, in which they describe cytokine patterns of inflamed joints from patients with Behçet’s disease (BD). The authors show that neutrophils and T lymphocytes are involved in a Th1-skewed inflammatory ... terminated while TNF blockage was continued. Cytokines were evaluated in the resected colon by analyzing mRNA expression levels of cytokine genes as previous...

Ngày tải lên: 09/08/2014, 14:22

... patient's surgery. JY and GC helped to conceive of the study and participated in the editing process. MB performed the electrodiagnostic studies in the neurology clinic. All authors read and approved the final ... for localizing the site of pathology and determining the severity of the condition, it does have limitations. Electrodiagnostic studies are uninformat...

Ngày tải lên: 10/08/2014, 10:20

... demyelinating plaque. The presence of alternating rings of myelin preservation or remyelination and myelin loss, consistent with demyelination, corre- sponds to the concentric type of demyelination, ... rapidly progressive course, sometimes fatal. Histologically, it is characterized by a large lesion consisting of rings of demyelination alternating with rings of intact myelin....

Ngày tải lên: 10/08/2014, 23:21

... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend th...

Ngày tải lên: 02/11/2012, 10:19

... regula- tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of...

Ngày tải lên: 19/02/2014, 06:20

... not maintained by the neighbouring tyrosine, while the W121F /Y1 22F mutant activity may be viewed as a commitment of the tyrosine residue to support the (somewhat higher) residual activity of the ... further identify amino acid side chains involved in the docking of cytochrome c, or in the presumed electron entry from cytochrome c to the Cu A center. Positions subje...

Ngày tải lên: 22/02/2014, 07:20

... respectively. Binding data was obtained by analytical ultracentrifugation using the direct binding assay as des- cribed in Experimental procedures. Inset: Linearized plot of the binding data for ... raises the possibility that any one or a combination of these properties may in uence the binding of apolipoproteins to lipoprotein particles. The capacity to fractionate lipid...

Ngày tải lên: 08/03/2014, 09:20