Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
Báo cáo y học: "Hypoxia in the pathogenesis of systemic sclerosis" ppt
... However, the role played byother members of the HIF family in the pathogenesis of SSchas not yet been investigated in detail.Insufficient response to hypoxia: dysregulation of angiogenesis in systemic ... procollagenprolyl hydroxylases (P4HA1 and P4HA2), lysyl oxidase (LOX)and lysyl hydroxylases (procollagen lysyl hydroxylase andprocollagen lysyl hydroxylase 2). Similar links betweenhypoxia and ... regulation of cellular responses to hypoxia.Upregulation of prolyl hydroxylase domainactivity in chronic hypoxiaInterestingly, PHD2 and PHD3 are induced by hypoxia in aHIF-1α-dependent manner, thereby...
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Báo cáo y học: " Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets" pps
... surprising considering the components of the ACR criteria. One of the criteria is the presence of erosions on the radiographs of hands and wrists. In the early phases of RA only 13% of the patients ... Additionally, erosions often initiallypresent in the small joints of the feet, and appear in the smalljoints of the hands at a later point in the disease course [6].Also, rheumatoid nodules are very ... Further evaluation of the effect of genetic variation in MMP3 on the level of joint damage in RA is thereforerequired. The increasing comprehension of the role of genetics in disease outcome in...
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Báo cáo y học: " Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study" pdf
... contributors to the pathogenesis of RA. MCsmay be considered the immunological sentinel of the syn-ovium, acting immediately in the event of joint trauma by liber-ating an array of proinflammatory mediators. ... to perpetuate the chronic process by their markedincreased accumulation in the synovial lining of the inflamedjoint and their ability to produce numerous proinflammatorycytokines and growth ... intracellularproinflammatory messages, which is currently represented by the strategy of selective protein tyrosine kinase (TK) inhibition.There is a growing body of evidence implicating mast cells(MCs)...
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Báo cáo y học: "Cytokines in the colon of a patient with Behçet’s disease" ppt
... Research & Therapy, in whichthey describe cytokine patterns of inflamed joints frompatients with Behçet’s disease (BD). The authors show thatneutrophils and T lymphocytes are involved in a Th1-skewedinflammatory ... terminated while TNF blockage was continued.Cytokines were evaluated in the resected colon by analyzingmRNA expression levels of cytokine genes as previouslydescribed [2]. Because of the extensive ... and highlyrelevant to the development of future immune-directedtherapy. Since the successful introduction of TNF blockers, itbecame apparent that Th1-cytokines might be key players in the immunopathology...
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Báo cáo y học: "Ultrasound in the diagnosis of a median neuropathy in the forearm: case report" doc
... patient'ssurgery. JY and GC helped to conceive of the study andparticipated in the editing process. MB performed the electrodiagnostic studies in the neurology clinic. Allauthors read and approved the final ... for localizing the site of pathologyand determining the severity of the condition, it does havelimitations. Electrodiagnostic studies are uninformativeabout structures surrounding the nerve ... history of degenerative disc disease and the nature of the injury, butan MRI and CT myelogram of the cervical spine showedno changes compared to his previous cervical spineimages. It was then...
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Báo cáo y học: " Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report" potx
... demyelinating plaque. The presence of alternating rings of myelin preservation or remyelinationand myelin loss, consistent with demyelination, corre-sponds to the concentric type of demyelination, ... rapidly progressivecourse, sometimes fatal. Histologically, it is characterizedby a large lesion consisting of rings of demyelinationalternating with rings of intact myelin. MRI is the method of ... be indicative of glioma. The diffuse infiltration of inflammatory cells,mainly reactive astrocytes and lipid-laden macrophages,and perivascular cuffing by T-lymphocytes favors the diagnosis of...
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Báo cáo y học: " Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice
... the gastrointestinal tissues from the cytotoxicity of CY in mice. We also profiled the changes of the expression of growth factors in gastric tissues in response to the damage by CY and protection ... protective effect of AP on CY-induced cytotoxicities in both the hemopoietic and gastrointestinal tissues was undefined. Any of these actions would extend the therapeutic application of CY in cancer ... Immunology and Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China Corresponding address: Prof. C.H. Cho, Department of Pharmacology, The University of...
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Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf
... regula-tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relativeexpression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... respect to the intensity of b-actin mRNA. The intensity representing HO-1 orHO-2 mRNA at the time of addition of actinomycin D (0 h) under each condition is considered to be 100%. Y. Zhang et...
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Tài liệu Báo cáo Y học: Mutations in the docking site for cytochrome c on the Paracoccus heme aa3 oxidase Electron entry and kinetic phases of the reaction pptx
... not maintained by the neighbouring tyrosine,while the W121F /Y1 22F mutant activity may be viewed asa commitment of the tyrosine residue to support the (somewhat higher) residual activity of the ... further identifyamino acid side chains involved in the docking of cytochrome c, or in the presumed electron entry fromcytochrome c to the CuAcenter. Positions subjected tomutagenesis in ... complex of the respiratory chains of mitochondria and many bacteria[1–4]. It catalyzes the reduction of oxygen to water, coupling the free energy of this reaction to the generation of a protongradient...
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Báo cáo Y học: Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractionated lipid emulsions pot
... respectively. Binding data was obtained byanalytical ultracentrifugation using the direct binding assay as des-cribed in Experimental procedures. Inset: Linearized plot of the binding data for ... raises the possibility that any one or acombination of these properties may in uence the binding of apolipoproteins to lipoprotein particles. The capacity tofractionate lipid emulsions into relatively ... affinity (Kd) for the large lipidparticles, are notably distinct in their maximum bindingcapacities (Table 2). In particular, the binding footprintfor the apoE4 isoform, corresponding to...
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