Báo cáo y học: "The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX-II, is unique compared with other markers of collagen turnove" doc

... distinctly to other markers. The present study adds to these series the unique response of CTX-II to oestrogen deficiency. There are many possible reasons why CTX-II is unique in its response to oestrogen ... urinary levels of CTX-II originate from degradation of newly synthesised colla- gen. Another important aspect of elevated urinary levels of CTX-I...

Ngày tải lên: 09/08/2014, 01:22

... distinctly to other markers. The present study adds to these series the unique response of CTX-II to oestrogen deficiency. There are many possible reasons why CTX-II is unique in its response to oestrogen ... ova- riectomy treated or not with oestrogen. It also investigates whether these collagen degradation products may relate to the breakdown of n...

Ngày tải lên: 09/08/2014, 13:22

... mice, cells with a high secretory burden are markedly compromised in their ability to cope with ER stress. On the basis of these results, P58 IPK is thought to be a key mediator of cotranslocational ... I, which catalyzes the first modification reac- tion to the complex-type glycan [139]. UDP-glucose, the substrate for re-glucosylation of N-glycan by UGGT, is synthes...

Ngày tải lên: 16/03/2014, 11:20

... IFN-γ-dominant T-cell cytokine response in joints of patients with long- standing RA [13]. IL-18 is a proinflammatory cytokine that plays an important role in the Th1-type immune response through the induction of ... chronic rheumatoid synovitis? Arthritis Rheum 1990, 33:768-773. 4. Panayi GS, Lanchbury JS, Kingsley GH: The importance of the T cell in initiating and main...

Ngày tải lên: 09/08/2014, 01:23

... that the diminution of NO synthesis by p38 MAPK inhibitors may contribute to their ability to blunt the anti-anabolic actions of IL-1. This pathway may or may not be relevant to human disease, ... at the low, but inhibitory, concentration of 0.1 ng/ml was used, and in this case there is a modest blunting of its action to diminish matrix proteoglycan synthesis by the...

Ngày tải lên: 09/08/2014, 01:23

... of formation of antibodies to infliximab (ATI) in these patients. This response is probably due to the preselection of the patients by the previous 3 years of per- sistent high-dose therapy with ... recommendations. The decision to use a cut- off score of 3 to indicate low disease activity is, at the moment, arbitrary but may serve as a basis for further dis...

Ngày tải lên: 09/08/2014, 06:22

... employees of Bristol-Myers Squibb (Princeton, NJ, USA) and own stock options. FL is an ex- employee of Bristol-Myers Squibb (Princeton, NJ, USA) but no longer possesses stock in Bristol-Myers ... co- stimulation, the partial inhibition observed here is likely to reflect the redundancy of the co-stimulation mechanism. This study analyzed the response in healthy volunteers...

Ngày tải lên: 09/08/2014, 10:20

... [34]. It is likely that, mast cell release of cytokines, inflammatory mediators and/or chemotactic factors triggered the rapid appearance of eosinophils to the site of inflammation within the first ... in 4% para- formaldehyde (PFA) in PBS and processed to paraffin for histology and immunochemistry. Histology and immunochemistry of dermal tissues Paraffin-processed dermal...

Ngày tải lên: 11/08/2014, 08:22

... medications by any route. The first administra tion of topical fluore s- cein was on the day of the cataract surgery. No reaction was elicited at this point, and this was probably due to the sensitising ... molecules on the “sensitised” cells. T his causes degra- nulation and the release of both the preformed and newly synthe sised pharmacologically active mediators of...

Ngày tải lên: 11/08/2014, 14:21

... managed the data. DF performed assays of CSF and plasma neopterin. ES designed the flow cytometry assays, directed the SFGH Clinical Immunology Laboratory that performed the flow cytometry assays ... Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA. 4 Department of Neurology, University of Washington, Seattle, WA, USA. 5 Depart...

Ngày tải lên: 10/08/2014, 05:22