Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... extracellular matrix and proteinase genes are regulated by TNF-induced MEK/ERK signallingWe further analysed the lists of genes that were induced by TNF using specific gene ontologies. Analysis of the ... activity of NFB and Sox9 in chondrocytes [10,12]. TNF-induced NFB DNA binding in immortalized chondrocytes is reduced by inhibition of MEK1/2 signalling [10]. TNF may thereforeregulate the expression ... significantly cate-gorized by the molecular function of their protein products intocategories that included hyaluronic acid binding activity(including Agc1 and Hapln1) and proteinase activity (includingMmp-9...

Báo cáo y học: "Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling" ppsx

... effects of diac-erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsinK. Moreover, we sought to gain new insight into the effects of the ... μg/mL).Effect of diacerein/rhein on intracellular signalling pathwaysTo gain insight into the mechanisms of these drugs on the OAsubchondral bone osteoblasts, we further studied the effect of the therapeutic ... cathepsin KSince MMP-13 and cathepsin K are produced by the murinecell line Raw 264.7, proteins not recognized by the commer-cially available ELISAs, determinations were performed usingactivity...

Tài liệu Báo cáo khoa học: Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines A possible strategy for the maintenance of intracellular heme level pdf

... regula-tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... responseduring acclimatization to hypoxia.ResultsEffects of hypoxia on HO-1 and HO-2 expression in human cell linesWe initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in...

Báo cáo y học: "Considerations for the inclusion of 2x mammalian genomes in phylogenetic analyses" ppsx

... number of Figure 2. Increase in gene number through evolutionary time for all lineages (blue lines) in the latest Ensembl version (version 59). The red line indicates the lineage leading to the ... duplications at the root of the eutherian mammals increases by only 4.5%. Moreover, the total number of supported duplications is reduced by only 10%. is suggests that the addition of low-coverage ... that the ‘addition of new placental mammal genomes in the gene trees increases the probability of ﬁnding a gene misplaced in the tree.’ We had anticipated that possibility in our study (page...

Báo cáo y học: " Factors predicting the outcome of customised foot orthoses in patients with rheumatoid arthritis: a prospective cohort stud" pps

... by the maximum possible sum of the item scores and thenmultiplied by 100. The scores range from 0 to 100; the higher the score the more pain, disability and activityrestriction respectively. ... baseline (before the start of the inter-vention) and at final follow up ( directly after the end of the intervention period). The intervention period consisted of one or more appointments with the ... pain(including RA-rela ted pain) a reduction of one point in NRS pain represented a MIC [36]. The NRS changescore in our study may therefore be interpreted as aclinically relevant reduction in...

Báo cáo y học: "Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1α in articular chondrocytes: involvement of HIF-1α in the pathogenesis of osteoarthritis" ppt

... luciferin by luciferase in the presence of extremely low levels of ATP. Aftercollecting the chondrocytes by scraping, cells were centri-fuged for 10 min at 500 × g in the cold. Chondrocytes pelletswere ... production in chondrocytes Chondrocyte activity was measured by the production of gly-cosaminoglycan (GAG) from cultured chondrocytes. Chondrocytes were cultured under either normoxic or hypoxicconditions ... radicals) may induce the expression of HIF-1α in articular chondrocytes. IL-1 has beenshown both to inhibit chondrocyte anabolic activity, including the down-regulation of proteoglycan synthesis,...

Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx

... following tissue injury in the upper urinarytract. Since the role of TGF-β1 in lower urinary tract inflammation is currently unknown, and sincegender-based differences exist in the setting of interstitial ... pathologicalchanges induced by CYP. Studies from other groups dem-onstrate that various inflammatory cytokines seem tomediate the pathogenesis of CYP-induced cystitis through the induction of high levels of iNOS ... determined by repeating the experiments described here in ovariect-omized rats [42,43].Our prior studies showed that other cytokines reach theirpeak by 4 h and decline by 24 h in the acute CYP...

Báo cáo y học: "A Comparative Effectiveness Study of Bone Density Changes in Women Over 40 Following Three Bone Health Plans Containing Variations of the Same Novel Plant-sourced Calcium"

... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... supplemen-tation. The increasing number of the elderly is ex-tending the progressive age-related decline in BMD, thereby increasing the need for additional supple-mental calcium and vitamin D3 [5]. There ... re-viewed in the meta-analysis cited above. As for the unusual finding of the increased BMD levels found in the three study groups, the superiority of Plan 3 over Plan 1 suggests that the physical...

Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

... subfamily of the cytoch-rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro-limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... presence of CYP3A5*1 allele does not predict the amount of CYP3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP3A5 protein, dual ... therapy although epigenetic factors must be taken into account [7]. The aim of the present study was to determine the impact of CYP3A5*1 and CYP3A5*3 genotype on the kinetics of tacrolimus in...

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