Báo cáo y học: " Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNF-induced MEK/ERK signalling" ppsx

... extracellular matrix and proteinase genes are regulated by TNF-induced MEK/ERK signalling We further analysed the lists of genes that were induced by TNF using specific gene ontologies. Analysis of the ... activity of NFB and Sox9 in chondrocytes [10,12]. TNF-induced NFB DNA binding in immortalized chondrocytes is reduced by inhibition of MEK1/2 s...

Ngày tải lên: 09/08/2014, 01:22

... effects of diac- erein/rhein on the synthesis of major proteases involved in bone remodelling/resorption, namely MMP-13 and cathepsin K. Moreover, we sought to gain new insight into the effects of the ... μg/mL). Effect of diacerein/rhein on intracellular signalling pathways To gain insight into the mechanisms of these drugs on the OA subchondral bone osteoblasts, we fu...

Ngày tải lên: 09/08/2014, 10:23

... regula- tion of HO-2 expression in human cells under hypoxia. In the present study, we have analyzed the effect of hypoxia on the expression levels of HO-1 and HO-2 in various types of human cell line, including ... respect to the intensity for the a-tubulin signal. Shown are the relative expression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and tho...

Ngày tải lên: 19/02/2014, 06:20

... number of Figure 2. Increase in gene number through evolutionary time for all lineages (blue lines) in the latest Ensembl version (version 59). The red line indicates the lineage leading to the ... duplications at the root of the eutherian mammals increases by only 4.5%. Moreover, the total number of supported duplications is reduced by only 10%. is suggests th...

Ngày tải lên: 09/08/2014, 22:23

... by the maximum possible sum of the item scores and then multiplied by 100. The scores range from 0 to 100; the higher the score the more pain, disability and activity restriction respectively. ... baseline (before the start of the inter- vention) and at final follow up ( directly after the end of the intervention period). The intervention period consisted of...

Ngày tải lên: 10/08/2014, 21:24

... luciferin by luciferase in the presence of extremely low levels of ATP. After collecting the chondrocytes by scraping, cells were centri- fuged for 10 min at 500 × g in the cold. Chondrocytes pellets were ... production in chondrocytes Chondrocyte activity was measured by the production of gly- cosaminoglycan (GAG) from cultured chondrocytes. Chondrocytes we...

Ngày tải lên: 09/08/2014, 06:23

... following tissue injury in the upper urinary tract. Since the role of TGF-β1 in lower urinary tract inflammation is currently unknown, and since gender-based differences exist in the setting of interstitial ... pathological changes induced by CYP. Studies from other groups dem- onstrate that various inflammatory cytokines seem to mediate the pathogenesis of CYP-induced c...

Ngày tải lên: 11/08/2014, 08:22

... unacceptable by the end of the study. In all three groups and sub-groups, none of the normal scores were abnormal by the end of the study. Thus, it was our conclusion that the absence of changes in the ... supplemen- tation. The increasing number of the elderly is ex- tending the progressive age-related decline in BMD, thereby increasing the need...

Ngày tải lên: 25/10/2012, 11:10

... subfamily of the cytoch- rome P450 (CYP) enzymatic system, is responsible for the metabolism of tacrolimus [10]. Specifically; tacro- limus is mainly metabolized by CYP3A4 and CYP3A5 enzyme isotype. ... presence of CYP3A5*1 allele does not predict the amount of CYP3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of...

Ngày tải lên: 26/10/2012, 09:32