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Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx

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Báo cáo y học: "High mobility group box-1 protein as a tumor necrosis factor-independent therapeutic target in rheumatoid arthritis." ppsx

... days. The induction of arthritis byrHMGB1 is primarily mediated by IL-1 as confirmed by the absence of arthritis in IL-1 receptor-deficient mice afterrHMGB1 administration [7]. Systemic administration ... administration of eitherneutralizing HMGB1 antigen-affinity purified polyclonal anti-bodies or the anti-inflammatory domain of HMGB1, termed the A-box protein, significantly reduced mean arthritis ... unchanged in one, and increased in three,rendering the authors’ results statistically insignificant. HMGB1mRNA expression remained unchanged after infliximab therapyas indicated by only two of the...
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Báo cáo y học: "Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model" pot

... mmHg of IAP. This might explain the absent effect of PEEP in reversing IAP induced FRC decline in the setting of grade IV IAH, respectively. However, we thinkthis reduced influence of PEEP in ... did notincrease the already high PaO2levels.InthepresenceofIAH,PEEPupto15cmH2Oonlypartially reversed the IAP, induced FRC decline in grade II IAH, and did not increase FRC in grade IV IAH.PEEP ... intra-abdominalpressures cannot be recommended to prevent FRC decline in the setting of intra-abdominal hypertension.IntroductionIntra-abdominal hypertension (IAH) is defined by the World Soci ety of...
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Báo cáo y học:

Báo cáo y học: "Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" potx

... interferon-inducible gene expressions in peripheral blood mononuclear cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16,IFI27, IFI30, IFI35, interferon-induced transmembrane ... of Figure 3Effect of TNF stimulation on gene expression in healthy individuals and systemic lupus erythematosus patientsEffect of TNF stimulation on gene expression in healthy individuals and ... Abnormal expression of the genes involved in cytokine networks and mitochondrialfunction in systemic juvenile idiopathic arthritis identified byDNA maicroarray analysis. Ann Rheum Dis 2009, 68:264-272.9....
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Báo cáo y học:

Báo cáo y học: " Interactions among type I and type II interferon, tumor necrosis factor, and -estradiol in the regulation of immune response-related gene expressions in systemic lupus erythematosus" pptx

... IL-12 in system lupus erythematosus. II: IL-12 production in vitro is correlated nega-tively with serum IL-10, positively with serum IFN-gamma and negatively with disease activity in SLE. Cytokine ... cells in vitro The expression of 15 IFI genes (IFIT1, IFIT3, IFIT5, IFI6, IFI16,IFI27, IFI30, IFI35, interferon-induced transmembrane protein1, ISG15, IRF7, OAS1, OASL, GBP1, and GBP2) in PBMCsupon ... and analyzedusing bioinformatics tools. Since interactions among TNF, IFN, -estradiol (E2), and IFN may regulate the expression of interferon-inducible (IFI) genes, stimulating and co-stimulatingexperiments...
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Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt

... because the sensitivity of in situ hybridization is lim-ited [50]. In the previous study, the synovial lining cells of RApatients were stained by the anti-IL-32 antibody [16]. Weassumed that the ... syn-ovial lining cells by in situ hybridization in our study. Anotherexplanation is the difference of types of RA. The distribution of IL-32 expression in synovial tissues may be dependent on the type ... chondrocytes of the joints. There would there-fore be no initiation of inflammation in the joints without the infiltration of bone-marrow-derived cells expressing hIL-32. The source of IL-32 remains...
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Báo cáo y học: "Human T-cell leukemia virus type I infects human lung epithelial cells and induces gene expression of cytokines, chemokines and cell adhesion molecules" ppt

... production of inflammatorycytokines and chemokines by HTLV -I- infected epithelialcells, in addition to that by infiltrating lymphocytes, mayalso play a role in the pathogenesis of HTLV -I- related ... infect primary rat retinal glial cells and induce gene expression of inflammatory cytokines. CurrEye Res 1997, 16:782-791.20. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi ... Yamane Hidaka, Saitama, Japan, 7Division of Immunology, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan and 8Center for Experimental Medicine, The Institute...
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Báo cáo y học:

Báo cáo y học: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)" pps

... proliferation of infected cells and also inhibitapoptosis by their pleiotropic actions. Since the HTLV -I provirus is randomly integrated into the host genome, the identification of integration ... the increase of CD4-positive T-lymphocytes in vivo byenhanced proliferation and suppressed apoptosis. In HTLV -I- infected individuals, no virions are detected in the serum. In addition, the infectivity of ... p53's activity in spite of loss of p300/CBP binding or in cells lacking NF-κB activation [33], indicating the mechanism of p53 inac-tivation by Tax needs further investigation.Although...
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Báo cáo Y học: Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity docx

Báo cáo Y học: Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity docx

... the 310helix, stabilized by stacking interac-tions of the pyrrolidine ring of Pro7 with the aromaticside chain of Tyr137. Modelling of the PRD1-superpeptide, which included two amino acid ... performed by the Src family kinase Fyn, which docksonto PAG using a dual-domain binding mode involving both SH3- and SH2-domains of Fyn. In this study, we investigated Fyn SH3-domain bind-ing to ... employ a well-conserved modular arrangement of interaction domains in the regulation of kinaseKeywordskinase activity; proline-rich motifs; protein–protein interactions; SH3 domain; tyrosinephosphorylationCorrespondenceT....
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Báo cáo Y học: A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants doc

Báo cáo Y học: A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants doc

... molecularmodelling, which showed that all amino-acid residuesinvolved in the catalytic activity of the A-chain and the sugar-binding activity in the B-chain are identical in both type- 2 RIPs.Expression of ... concerns their specific agglutination activity and the inhibition of agglutination by lactose and fetuin. In addition, both type- 2 RIPs exhibited the same RNAN-glycosylase activity. It can be ... described previously [6]. The carbohydrate-binding specificity of the type- 2 RIPswas checked by inhibition of agglutination of trypsin-treated rabbit erythrocytes with galactose and fetuin.Therefore...
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Báo cáo y học:

Báo cáo y học: "Relationship among Dexamethasone Suppression Test, personality disorders and stressful life events in clinical subtypes of major depression: An exploratory study" pot

... variable, significantfindings were found concerning the endogenous axis of DMS and the HDRS depressive index. The interaction of PD and DST produced significant findings concerningage, age of onset, ... University of Thesssaloniki, Greece, 2Lab of Clin Neurophysiology, 1st Department of Neurology Aristotle University of Thesssaloniki, Greece and 3Lab of Biochemistry, Aristotle University of Thesssaloniki, ... [25]. While it is not possible tointerpret what is the cause and what is the effect, it is inter-esting that there are papers in the international literaturesuggesting that conditions of internal...
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