Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" ppsx
... participated in the conception and design of the project and in the analysis and interpretation of data and contributedsubstantially to the drafting of the manuscript. VFP partici-pated in the ... notsignificant in the univariate analysis and had no impact on the frequency of the metabolic syndrome. Conclusion In summary, this study suggests that the presence of the met-abolic syndrome in RA appears ... It is therefore possible that, in RA patients, alterations in body fat/muscle may have already occurred as part of the dis-ease process and thus any additional changes that areinduced by long-term...
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Báo cáo y học: "Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study" pptx
... will have anincreased prevalence of each of the individual components of the metabolic syndrome (dyslipidaemia, hypertension, hyperg-lycaemia, and central obesity) as well as the metabolic syn-drome ... It is therefore possible that, in RA patients, alterations in body fat/muscle may have already occurred as part of the dis-ease process and thus any additional changes that areinduced by long-term ... Conversely,it may be that patients with RA have significantly modified theirrisk factors for the metabolic syndrome as a consequence of inflammation and that the addition of GC use cannot worsenthese...
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Báo cáo y học: " High Human T Cell Leukemia Virus Type-1(HTLV-1) Provirus Load in Patients with HTLV-1 Carriers Complicated with HTLV-1-unrelated disorders" docx
... Uemura A, Sugahara K, Nagai H, Murata K, Hasegawa H, Hirakata Y, Tsukasaki K, Yamada Y, Kamihira S: An ATL cell line with an IgH pseudo-rearranged band pattern by southern blotting: a pitfall of ... expansion. Cases 3-14; aberrant bands mainly with faint multiple clonal bands, Final diagnosis was based on the integrated findings of an LN SBH test and clinico-pathological examinations. ALCL; ... Nagai H, Murata K, Hasegawa H, Hirakata Y, Takasaki Y, Tsukasaki K, Yamada Y: Proviral status of HTLV-1 integrated into the host genomic DNA of adult T-cell leukemia cells. Clin Lab Haematol 2005,...
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Báo cáo y học: "Drotrecogin alfa (activated): real-life use and outcomes for the UK" ppt
... study and critical revision of the man-uscript, and have read and approved the final manuscript.Additional filesAcknowledgementsWe thank all of the patients and staff in the participating units. ... observed in PROWESS. A statistical anal-ysis plan was agreed a priori. Use of DrotAARate of use of DrotAA, both in patients with severe sepsis and across critical care units, was calculated. Case ... comparativeaudit of adult, general critical care units (including intensivecare and combined intensive care and high dependency units) in England, Wales and Northern Ireland, and is coordinated byICNARC....
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Báo cáo y học: "Musculoskeletal ultrasound imaging of the plantar forefoot in patients with rheumatoid arthritis: inter-observer agreement between a podiatrist and a radiologist" pptx
... metatarsal area of a study participant with RAFigure 1 A MSUS image of the left foot plantar metatarsal area of a study participant with RA. The MSUS image demonstrates bursitis as a demarcated ... aspect of each foot.5. Scans were taken according to the EULAR standard approach from the plantar aspect of the foot [14].6. Each MTP joint and inter-metatarsal space was scanned longitudinally and ... patient's global impression of health and disease activity and the number of painful, tender and swollen joints calculated as DAS28.Imaging Data The presence and location of any bursitis...
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Báo cáo y học: "Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study" doc
... involved in the acquisition of the data. GB took part in the data analysis and EG and MH in carrying out the immunoassays. GB, LA and GW participated in the interpretation of the data. All authors participated ... to adalimumab(hence the adalimumab-adalimumab combination) wereneg ative in the assay for anti-inflixim ab (the infliximab-infliximab combination) as well as in the assay whereadalimumab was ... treated with either adalimu-mab and concomitant DMARD therapy, or adalimumabmonotherapy. All patients used adalimumab 40 mg sub-cutaneously every other week. In patients with an inade-quate...
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Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
... conducted data analysis and drafted the manuscript.DC, GK and JVVZ participated in the design of the study and helped with data analysis and drafting the manuscript. All authors read and approved the ... 2 of 5RESEA R C H ART I C L E Open Access The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional studyAamer Sandoo1,2*, ... were examined by administration of a 500-μgsublingual glyceryl trinitrate tablet (Alpharma, Barnsta-ple, UK) while the brachial artery was imaged continu-ously for five minutes. The intraobserver...
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Báo cáo Y học: Chromatin assembly Cooperation between histone chaperones and ATP-dependent nucleosome remodeling machines docx
... ourunderstanding of the machinery and mechanism of chro-matin assembly. The main players in chromatin assembly that havebeen identified to date are the histone chaperones and a protein complex that ... consistent with the available data is thatactivation of Rad53 by the DNA damage checkpointreleases ASF1 into the vicinity of the DNA lesion in order tocontribute to the assembly of the newly synthesized ... DNAinto chromatin (Fig. 4B).THIS IS JUST THE BEGINNINGWe are only now gaining real insight into the machinery and mechanism of chromatin assembly. Chromatin assemblyrequires a negatively...
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Báo cáo y học: "β A randomized, controlled trial of interferon-β-1a (Avonex®) in patients with rheumatoid arthritis: a pilot study [ISRCTN03626626]" pptx
... originalURL.Abstract The objective of this study was to evaluate the safety and possible efficacy of IFN-β- 1a for the treatment of patients with rheumatoid arthritis (RA). Twenty-two patients with active ... of RA and potentially lead to a reduc-tion in symptoms and increase in function in patients with RA. The present study was designed to assess the effects of the use of IFN-β- 1a for the treatment ... has changed the paradigm of treatment options.However, despite the introduction of anti-cytokine therapy,there remains a significant unmet need for additionaltherapy in the treatment of RA...
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Báo cáo y học: "NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor" docx
... with 100 μl emulsion intrader-mally at the base of the tail. After 21 days (day 0), the sameamount of the antigen emulsified in the same adjuvant wasintradermally injected at the base of the ... byNF-κB in agreement with the in vitro studies. RANKL inducesNFATc1 expression via three intracellular signaling pathways;an NF-κB pathway, a mitogen-activated protein kinase path-way, and ... translocation and activation of NF-κB by dehydroxymethylepoxyquinomicin.J Biol Chem 2002, 277:24625-24630.15. Miyajima A, Kosaka T, Seta K, Asano T, Umezawa K, Hayakawa M:Novel nuclear factor...
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