Báo cáo y học: "HIF-mediated articular chondrocyte function: prospects for cartilage repai" pdf

... in hypoxic induction of the human articular chondrocyte phenotype It has long been known that the chondrocyte phenotype is unstable in culture [26-28]. Moreover, chondrocyte pheno- Figure 1 Hypoxia-inducible ... appro- priate for therapeutic application since, being a non-specific hydroxylase inhibitor, it also inhibits procollagen hydroxylases such as prolyl and lysyl hydroxylases,...

Ngày tải lên: 09/08/2014, 01:22

... Belimumab Study Group: Biologic activity and safety of beli- mumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus. ... amyloid A; HDL, high-density lipoprotein; sTL, stimulated T lymphocyte; MΦ, macrophages. Figure kindly provided by Prof. Jean-Michel Dayer (Geneva, Switzerland). Figure 2 Leptin produced...

Ngày tải lên: 12/08/2014, 11:22

... Jagneaux V, Poitevin F, Malcus C, Accart N, Layani MP, Aymard M, Bernon H, Bienvenu J, Courtney M, Doring G, Gilly B, Gilly R, Lamy D, Levrey H, Morel Y, Paulin C, Perraud F, Rodillon L, Sene C, ... viral entry by using apically sited receptors such as the UTP-binding P 2Y2 receptor. Novel viruses are increasingly being investigated, and cationic liposomes and polymers are increasingly bein...

Ngày tải lên: 12/08/2014, 18:20

... is also commonly used, but less so by allergists than by other practitioners. The sensitivity and specificity of these testing methods may vary by type of causative allergen and type of allergic ... Bahna* Address: Allergy and Immunology Section, Louisiana State University Health Sciences Center; Shreveport, Louisiana, USA Email: Birjis Chinoy - info@allergy-asthmasolutions.com; Edgar Yee - t...

Ngày tải lên: 13/08/2014, 13:22

... risk for cartilage degeneration by decreasing the ability of chondrocytes to maintain and repair the articular cartilage tissue [4-6]. The mitotic and synthetic activity of chondrocytes decline ... immunostaining for nitrotyrosine was expressed as a mean number of nitrotyrosine-positive cells per field. Chondrocyte activity Chondrocyte activity was measured as the production of...

Ngày tải lên: 09/08/2014, 06:22

... undecaprenyl pyrophosphate synthase; DDPPS, dehydrodolichyl pyrophosphate synthase; PPPS, polyprenyl pyrophosphate synthase; GPPS, geranyl pyrophosphate synthase; FPPS, farnesyl pyrophosphate synthase; ... geranylgeranyl pyrophosphate synthase; FGPPS, farnesylgeranyl pyrophosphate synthase; HexPPS, hexa- prenyl pyrophosphate synthase; HepPPS, heptaprenyl pyrophosphate synthase; OPPS, octapren...

Ngày tải lên: 08/03/2014, 22:20

... [32]. Cytokines produced by the synovium and chondrocytes, especially IL-1 and tumor necrosis factor alpha (TNF-α), are also key players in the degradation of cartilage [29]. IL-1β is spontaneously ... every 4 days from day 56 to day 92 Increased production of TIMP-1, the MMP inhibitor; Yasui et al., 1992 [68] Bovine articular chondrocytes; HA of various MWs Yes N/A reduced ratio of strom...

Ngày tải lên: 09/08/2014, 01:21

... test (day 29). HA completely prevented proteoglycan loss from the epiphyseal growth plate and articular cartilage on day 8, but induced proteoglycan loss from the epiphyseal growth plate on day 29. ... arthritis, as shown by amelioration of clinical signs (day 15), by prevention of proteoglycan loss in the articular cartilage and epiphyseal growth plate, and by prevention of structura...

Ngày tải lên: 09/08/2014, 06:22

... currently is no appropriate gene transfer system that could be used clinically Figure 3 Analysis of cartilage and systemic toxicity of recombinant TRAIL (rTRAIL)Analysis of cartilage and systemic ... Analysis of glycosaminoglycan (GAG) synthesis by cartilage following rTRAIL injection. Cartilage shavings were taken from the femoral condyles of rabbits 48 h post-injection and analyze...

Ngày tải lên: 09/08/2014, 07:20

... proteoglycan synthesis of human articular chondrocytes: the role of nonenzymatic glycation. Arthritis Rheum 1999, 42:1003-1009. 48. Schafer SJ, Luyten FP, Yanagishita M, Reddi AH: Proteoglycan metabolism ... biosyn- thetic activity of articular cartilage. In the present study we investigated the influence of a 3-tesla EMF on the matrix bio- synthesis of chondrocytes derived from bovine...

Ngày tải lên: 09/08/2014, 08:22