Báo cáo y học: "Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy" ppt

... not for citation purposes) Vol 10 No 6 Research article Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab ... enzyme immunoassay; ELISA: enzyme-linked immunosorb- ent assay; MCV: mutated citrullinated vimentin; PTPN22: protein tyrosine phosphatase nonreceptor type 22...

Ngày tải lên: 09/08/2014, 01:22

... anti -mutated citrullinated vimentin (anti-MCV) and anti-second- generation cyclic citrullinated peptide (anti-CCP2) for the clinical diagnosis of rheumatoid arthritis (RA) in early arthritis, using cut ... IgG (rheumatoid factor) and antibodies to cit- rullinated protein/peptide antigens (ACPAs). Rheumatoid fac- tor is not specific to RA, because it is present in...

Ngày tải lên: 09/08/2014, 10:22

... released in increased amounts in response to growth factors and proinflammatory cytokines, suggesting involvement in the pathophysiology of RA [24]. The few stud- ies of anti-MCV usually found performance ... against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrull...

Ngày tải lên: 09/08/2014, 13:22

... Reid DM: Predicting erosive disease in rheumatoid arthritis. A longitudinal study of changes in bone density using digital X-ray radiogrammetry: a pilot study. Rheumatology (Oxford) 2004, 43:1561-1564. 20. ... anti-CCP and ESR as important predictors of bone involvement in RA. Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by synovitis a...

Ngày tải lên: 09/08/2014, 14:22

... and 60°C for 1 min. In addition, the RT- PCR included an initial reverse transcription step of 50° C for 30 min. The linearity and sensitivity of the XMRV assay were determined by using a dilution ... length was inserted into pACYC-MS2 [12] (previously con- structed by our laboratory) with three C-variant pac sites inserted at the beginning, middle, and end. This sequence was obta...

Ngày tải lên: 12/08/2014, 01:21

... not always indicate malignancy and therefore a tissue biopsy is always mandatory to confirm the diagnosis. Introduction Sarcoidosis is an uncommon granulomatous disease primarily manifesting itself ... bleomycin, vinblastine, and dacarba- zine; EBV, Epstein-Barr virus; FDG, fluorodeoxyglucose; HL, Hodgkin’s lymphoma; LN, lymph node; PET-CT, positron emission tomography-computed tomograp...

Ngày tải lên: 11/08/2014, 17:21

... rheumatologist answered a questionnaire inquiring about the initial symptoms as reported by the patient (type of initial joint symptoms, localization and distribution of initial joint symptoms, ... in the anti-CCP-negative patients and anti- CCP-positive patients was similar at 118 min and 123 min, respectively. In both groups symptoms started with pain and swelling, predomi...

Ngày tải lên: 09/08/2014, 06:23

... collagen in rheumatoid arthritis Andrew D Cook 1 , Robyn Gray 1 , John Ramshaw 2 , Ian R Mackay 1 and Merrill J Rowley 1 1 Department of Biochemistry and Molecular Biology, Monash University, Clayton, ... both T and B lymphocytes, with arthritis being initiated by complement-fixing autoantibodies that bind to CII in the cartilage matrix [2]. In humans, IgG-pro- ducing B c...

Ngày tải lên: 09/08/2014, 01:23

... HIV-1 in vivo and piggyback the virus into tissues and through the blood brain barrier into the central nervous system [5,6]. With their differentiation into macrophages, and according to the stimulation ... permissive to HIV-1, and albeit remaining more restrictive to the virus than other cell types, become overtly infected. The virus takes hold of these cells and uses them...

Ngày tải lên: 12/08/2014, 23:23

... representative study population, defining the intervention and deploying it in a standardised manner, and measuring appropriate outcomes. The aim of this review is to give clinicians insight into the process ... current treatments and outcomes in that population, defining the study intervention and the treatment to be used in the control group, and deploying the interventi...

Ngày tải lên: 13/08/2014, 08:21