Báo cáo y học: "All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation" ppsx

... regulated by retinoic acid and is often induced upon activation of this path- way [33]. We were interested in confirming these findings and determining the kinetics of Crabp2 induction during OA. ... expression of Crabp2 is regulated by retinoic acid, or indirectly, because increased CRABP2 would increase retinoic acid receptor transcriptional activity. Inappropriate...

Ngày tải lên: 09/08/2014, 01:22

... endothelial cells into the damaged site. It has been showed that fibroblasts cultured in presence of increasing doses of HA have an increased production of pro-inflammatory cyto- kines such as ... matrix and scavenging of free radicals [4,5]. However, recent data indicated a certain role played by undersulfated glycosaminoglycans, such as HA, on hydroxyapatite crystal for...

Ngày tải lên: 03/11/2012, 11:35

... min respectively. BeadArray gene expression analysis We used an integrated genomics profiling and computational biology based strategy to identify the key genes and gene clusters whose expression ... domain 1 and it is a member of the CDGSH domain-containing family (http://amigo.geneontology.org/cgi-bin/amigo/sea rch.cgi?action=query&view=query&query=ZCD1&se arch_const...

Ngày tải lên: 03/11/2012, 11:44

... Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan 2 Division of Hematology, Department of Internal ... changes in murine lung injury induced by bleomycin. A morphologic study. Am J Respir Crit Care Med 1997, 156:1937-1944. 19. Blank M, Levy Y, Amital H, Shoenfeld Y, Pines M, Gen...

Ngày tải lên: 09/08/2014, 08:22

... disease activity score, the use of this score represents a handicap for the evaluation of the efficacy of cyclosporin A on disease activ- ity. On the other hand, cyclosporin A inhibits the synthesis of IL-17 ... Spain. Throughout the follow-up of the EMECAR cohort, the percentage of patients without any DMARD declined while the frequency of patients on combined therapy increased...

Ngày tải lên: 09/08/2014, 13:22

... also determined in synovial tissue (ST) biopsies of 10 RA and 10 SpA patients. The production of NGF by monocytes and lymphocytes was assessed by flow cytometry of SF cells, synovial tissue derived ... enhancing chemotaxis and production of superoxide by neutrophils [22]. NGF is also involved in humoral immune responses by acting as an autocrine survival factor maintai...

Ngày tải lên: 09/08/2014, 14:21

... Hebeishy NA, Rahmy AI: A post- mortem study of the thymolymphatic system in protein energy malnutrition. J Trop Med Hyg 1982, 85:109-114. 19. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE: Intrathymic ... peaks indicating the absence of seasonal effects on overall CD8 + T cell clonal diversity. Table 2 Lymphocyte phenotypes, in the population by season of birth in 18-23 years old me...

Ngày tải lên: 10/08/2014, 05:21

... suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK 1/2 pathway independently of RAR activation Mélanie Kirchmeyer, Meriem Koufany, Sylvie ... only ATRA inhibited IL-1-induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK 1/2 pathway and subsequent activation of AP-1 and NF-IL-6 i...

Ngày tải lên: 09/08/2014, 01:22

... the anti-inflammatory cytokine IL-10 over the pro-inflammatory cytokine IFN-γ, resulting in the over- all skewing (immune deviation) of the cytokine response to an anti-inflammatory type [26]. ... deviation of the cytokine response, caused either by decreased Th1-type cytokines and/or by enhanced Th2-type cytokines leading to the regression of an autoimmune disease, is reminiscent...

Ngày tải lên: 09/08/2014, 10:20