... evidence for hypoxia in
inflammatory and destructive joint disease, and discusses the
interplay between alterations in oxygen tension, vascularity
and inflammatory signalling pathways. In the present ... for
myeloid cell-mediated inflammation and bactericidal capacity
of phagocytes, suggesting crosstalk between angiogenesis
and inflammation.
Review
Hypoxia
The role...
... molecular basis of hypoxia
tolerance, not only in muscle but also in numerous other
diseases (including cancer and RA) and in settings where
induction of hypoxia tolerance might be of therapeutic ... contains an evolutionarily conserved LxxLAP
consensus motif for hydroxylation by PHD, thus linking two
major human signalling systems, namely NF-κB and HIF.
Mimicking hyp...
... non-coding sequence of 20 bp
and 3 conserved domains including F
1
ATP synthase beta
subunit nucleotide-binding domain, ATP synthase alpha/
beta chain N terminal domain, ATP synthase alpha/beta
chain ... administration of the host
VP28-Binding protein PmRab7 ( or an antibody against
it ) could reduce and delay mortality upon subsequent
Figure 3 Compete ELISA binding assay. Graph showi...
... W, Yamin M, Noda M, et al.:
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-
catenin through inactivation of the intrinsic catalytic activity of the
receptor-type protein ... pathway is possibly medi-
ated by the c-Src, which binds to the intracellular domain
of syndecan-3 and subsequently alters the activity of cort-
actin [68].
ALK is a receptor tyrosine k...
... derivative of 8-phe-
nyltheophylline (8-PT, 8-(p-sulphophenyl)-theophylline
(8-SPT) (Research Biochemicals Inc.), to the arterial and
venous perfusate. Single HA doses of acetylcholine (ACh,
10
-7 ... inhibi-
tion of HA responses by 8-SPT between intra-arterial and
intra-portal injection of ATP despite a longer lag-time
between injection and response following intra-portal
injec...
... interpretation of
the genotypic resistance information. In particular, the
decline in resistance can be partially explained by the fact
that in the early years of 2000, treatment initiation in
patients ... treated
population in Portugal, since every patient on treatment is
normally genotypically tested when failing. Our analysis
was performed using the number of patients with...
... important role in the pathogenesis
of rheumatoid arthritis (RA) (reviewed in [1]). In the synovial
joint, infiltrating T cells are predominantly of the CD4
+
pheno-
type and are often found in the ... clinical evaluations of patients and manuscript
preparation. VM and CT were the principle investigators and
participated equally in the planning and coordination...
... penicillin and 0.1 mg/ml
streptomycin). Cells were incubated in serum-free MEM
containing 1 μg/ml trypsine, 2 mM L-glutamine, 100 U/ml
penicillin and 0.1 mg/ml streptomycin.
Determination of virus ... Friedrich-Löffler
Institute (FLI) Tübingen a nd the Department of Medical
Virology and Epidemiology of Virus Diseases of the
Hygiene Institute at University of Tübingen, respec...
... second binding loops of cystatin B and
family 2 cystatins and also what residues of this loop in
cystatin A may participate in the interaction.
To elucidate the role of the second binding loop of ... participates in the inhibition of papain
and most likely also of cathepsin L. The side chains of
Leu73 and Pro74 jointly contribute 45% of the total
unitary free...
... and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the hydrophobicity of the binding site.
To ... (k
cat
/K
m
)forp-hydroxyphenylgly-
cine methyl ester and phenylglycine methyl ester that were
similar to the wild-type values, whereas the specificity con-
stants for p-hydroxyphenyl...