Báo cáo y học: "The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis" ppt

... evidence for hypoxia in inflammatory and destructive joint disease, and discusses the interplay between alterations in oxygen tension, vascularity and inflammatory signalling pathways. In the present ... for myeloid cell-mediated inflammation and bactericidal capacity of phagocytes, suggesting crosstalk between angiogenesis and inflammation. Review Hypoxia The role...

Ngày tải lên: 09/08/2014, 01:22

... molecular basis of hypoxia tolerance, not only in muscle but also in numerous other diseases (including cancer and RA) and in settings where induction of hypoxia tolerance might be of therapeutic ... contains an evolutionarily conserved LxxLAP consensus motif for hydroxylation by PHD, thus linking two major human signalling systems, namely NF-κB and HIF. Mimicking hyp...

Ngày tải lên: 09/08/2014, 13:22

... non-coding sequence of 20 bp and 3 conserved domains including F 1 ATP synthase beta subunit nucleotide-binding domain, ATP synthase alpha/ beta chain N terminal domain, ATP synthase alpha/beta chain ... administration of the host VP28-Binding protein PmRab7 ( or an antibody against it ) could reduce and delay mortality upon subsequent Figure 3 Compete ELISA binding assay. Graph showi...

Ngày tải lên: 12/08/2014, 04:20

... W, Yamin M, Noda M, et al.: Pleiotrophin signals increased tyrosine phosphorylation of beta beta- catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein ... pathway is possibly medi- ated by the c-Src, which binds to the intracellular domain of syndecan-3 and subsequently alters the activity of cort- actin [68]. ALK is a receptor tyrosine k...

Ngày tải lên: 12/08/2014, 11:22

... derivative of 8-phe- nyltheophylline (8-PT, 8-(p-sulphophenyl)-theophylline (8-SPT) (Research Biochemicals Inc.), to the arterial and venous perfusate. Single HA doses of acetylcholine (ACh, 10 -7 ... inhibi- tion of HA responses by 8-SPT between intra-arterial and intra-portal injection of ATP despite a longer lag-time between injection and response following intra-portal injec...

Ngày tải lên: 13/08/2014, 13:20

... interpretation of the genotypic resistance information. In particular, the decline in resistance can be partially explained by the fact that in the early years of 2000, treatment initiation in patients ... treated population in Portugal, since every patient on treatment is normally genotypically tested when failing. Our analysis was performed using the number of patients with...

Ngày tải lên: 13/08/2014, 06:20

... important role in the pathogenesis of rheumatoid arthritis (RA) (reviewed in [1]). In the synovial joint, infiltrating T cells are predominantly of the CD4 + pheno- type and are often found in the ... clinical evaluations of patients and manuscript preparation. VM and CT were the principle investigators and participated equally in the planning and coordination...

Ngày tải lên: 09/08/2014, 10:21

... penicillin and 0.1 mg/ml streptomycin). Cells were incubated in serum-free MEM containing 1 μg/ml trypsine, 2 mM L-glutamine, 100 U/ml penicillin and 0.1 mg/ml streptomycin. Determination of virus ... Friedrich-Löffler Institute (FLI) Tübingen a nd the Department of Medical Virology and Epidemiology of Virus Diseases of the Hygiene Institute at University of Tübingen, respec...

Ngày tải lên: 11/08/2014, 08:21

... second binding loops of cystatin B and family 2 cystatins and also what residues of this loop in cystatin A may participate in the interaction. To elucidate the role of the second binding loop of ... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free...

Ngày tải lên: 17/03/2014, 10:20

... and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To ... (k cat /K m )forp-hydroxyphenylgly- cine methyl ester and phenylglycine methyl ester that were similar to the wild-type values, whereas the specificity con- stants for p-hydroxyphenyl...

Ngày tải lên: 17/03/2014, 23:20