Báo cáo y học: "Gene therapy of the rheumatic diseases: 1998 to 2008" ppt

... strength to strength. The preceding decade had seen the number of human gene therapy trials grow, since the first properly authorized gene transfer to a human in 1989, to a total of 368 by 1998. ... development. Advances in technology Central to any successful gene therapy is the ability to transfer genes efficiently and safely to the target cells. The same ba...

Ngày tải lên: 09/08/2014, 01:22

... spatial distribution of chondrocytes and the lack of initial mechanical stability, (b) the suture of the periosteal flap into the surrounding healthy cartilage and the necessity of a perifocal solid ... expression of the cell cycle inhibitor p27 and a repressed expression of the cell cycle regulatory gene cyclin D2, and it also affects other immune cells. The mecha...

Ngày tải lên: 09/08/2014, 01:22

... germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human germline gene therapy would have the following ... purpose of this paper is to consider the potential for applying the available genetic modification (GM) technologies to the goal of achieving human germline gene th...

Ngày tải lên: 03/11/2012, 10:01

... the application of gene therapy in RA, and the feasibility of gene therapy was recently demonstrated in phase I clinical trials. Keywords: arthritis, cytokines, gene therapy, genetic synovectomy, ... surgically, chemically or by radiation therapy, immediately stops the arthritic process and delays recurrence of disease in that joint for many years [8]. With gene therapy it...

Ngày tải lên: 09/08/2014, 01:24

... with the latest combination therapy. However, existing data support therapy of the patient with compensated cirrhosis. Cirrhotic patients may tolerate therapy less well, given the propensity ... related cytopenias. The use of these agents is costly and has not been studied rigorously in a randomized controlled format to assess their value and impact on efficacy of...

Ngày tải lên: 31/10/2012, 17:11

... activity of the mutant m-126 Luc even below that of the wild-type p-126 Luc. Analysis of the binding affinity of the putative FXRE site for the orphan nuclear receptor FXR To characterize the FXRE ... with members of the HNF transcription factor family and general factors of the transcription initiation complex. In addition, the IR-1 element obviously contribute...

Ngày tải lên: 17/03/2014, 23:20

... Score; and/or the pain subscale of the Health Related Quality of Life Table 1 Level of evidence for evaluating the efficacy of exercise therapy in the management of osteoarthritis of the hip Level of evidence ... rehabilita- tion, physical therapy, physiotherapy, hydrotherapy, aquatic, strength(ening), resistance, aerobic, endurance, stretch(ing)(es), train(ing), pr...

Ngày tải lên: 09/08/2014, 14:22

... gene therapy (review). Oncol Rep 2002; 9: 57-60. 18. Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai ... activity [19]. Since histone methylation has been proposed as an important epigenetic mechanism to suppress cancer, the histone methyltransferase activ- ity of the PR domain may as...

Ngày tải lên: 25/10/2012, 11:15

... During the therapeutic process, real-time estimation of the therapeutic effect was carried out by the computer system through the graphic changes in the target field and the hyperecho of the ... and use of laboratory animals from the Ministry of Science and Technology of the People’s Republic of China. Instruments HIFU ablation was performed with a HIFU tu-...

Ngày tải lên: 25/10/2012, 11:18

... as the high- affinity peak of wild-type LPL. The LPL in the eluate was detected by Western blot with LPL polyclonal antibody 7640. The fraction number of the high-affinity peak was the same for the ... orientation, the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the other face each other, t...

Ngày tải lên: 21/02/2014, 15:20