Báo cáo y học: "Transcription profiling of rheumatic diseases" doc
Báo cáo y học: "Transcription profiling of rheumatic diseases" doc
... 2
Discovery of molecular rheumatic disease subtypes. Schematic overview of the discovery of rheumatic disease subtypes in peripheral blood cells
and affected target tissues. Heterogeneity in rheumatic ... treatment by
identifying subgroups of patients who are most likely to respond.
Gene expression profiling in affected target
tissues
One of the first studies of gene expre...
Báo cáo y học: "Cytokines in chronic rheumatic diseases: is everything lack of homeostatic balance" pps
... IL-10 not only fails to reduce the
subsequent production of TNF in response to lipopoly-
saccharide, which may simply indicate a loss of function of
the anti-inflammatory activity of IL-10, but ... cytokine network is a homeostatic system that may be
comparable with the acid/base equilibrium. The biological
activity of any cytokine in biological fluids can be interpreted
correctly o...
Báo cáo y học: " Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms" pps
... Inhibition of Th2
cytokine synthesis
Transcription factors
of Th2 cytokines
Inhibition of synthesis
of transcription factors
on the level of
transcription
Imiquimod/resiquimod
ODN decoys
Inhibition of ... activation
of TCR and/or
costimulatory receptor
molecules
Inhibitors of ERK, MEK 1/2
Inhibition of signal
transduction cascade
on the way to synthesis
of costimulatory
re...
Báo cáo y học: "Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications" doc
... obesity (due to a
surplus of energy), hypertrophic adipocytes are characterized
by a hyperlipolytic state that is resistant to the antilipolytic
effect of insulin [19]. The non-esterified fatty acids ... to
determine whether treatment of underlying causes of MetS
(for example, insulin resistance in the absence of hyper-
glycemia) results in better outcome beyond the levels
achieved...
Báo cáo y học: "Vascular involvement in rheumatic diseases: ‘vascular rheumatology" pps
... similarly to the RA joint, are characterized
by enhanced accumulation of inflammatory monocytes/
macrophages and T cells. These inflammatory leukocytes
abundantly produce proinflammatory cytokines, ... smoking, physical
inactivity, obesity, hypertension, dyslipidemia, and diabetes
mellitus may be implicated in accelerated atherosclerosis
[36-38,44]. Yet excess CVD mortality occurs predomina...
Báo cáo y học: " Ten years of Genome Biolog" doc
... without you!
Published: 29 January 2010
Garvey Genome Biology 2010, 11:101
http://genomebiology.com/2010/11/1/101
doi:10.1186/gb-2010-11-1-101
Cite this article as: Garvey C: Ten years of Genome ... the first port of call for author
inquiries. Along with its staff, the support of our readers
and advisory board has helped shape Genome Biology
into the journal that it is today. We are c...
Báo cáo hóa học: " Quantitative profiling of housekeeping and Epstein-Barr virus gene transcription in Burkitt lymphoma cell lines using an oligonucleotide microarray" docx
... synthesized by Sigma-Genosys (Pampisford, UK).
Slides coated with 3-glycidoxypropyl-trimethyl silane
("epoxysilane") were obtained from Scienion (Berlin,
Germany). 20 μM solutions of ... finally 0.2 × SSC, and dried in the
machine with a flow of nitrogen.
Microarray experiments and analysis of data
The reproducibility of microarray results was tested by
performing a set of...
Báo cáo y học: "Gene therapy of the rheumatic diseases: 1998 to 2008" ppt
... expression of its decoy
receptor, DcR2 [72].
T lymphocytes also home to sites of inflammation and
immune reactivity. Like APCs, they may be genetically
modified and used to target multiple sites of disease ... Cher-
najovsky Y: A novel doxycycline inducible autoregulatory
plasmid which displays ‘on’/’off’ regulation suited to gene
therapy applications. Gene Ther 2000, 7:2061-2070.
53....
Báo cáo y học: "Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factor" ppt
... Brinck-
erhoff CE: A synthetic triterpenoid selectively inhibits the
induction of matrix metalloproteinases 1 and 13 by inflamma-
tory cytokines. Arthritis Rheum 2001, 44:1096-1104.
64. Suh N, Wang Y, ... primary
rabbit synovial fibroblasts, only IL-1 is capable of inducing
MMP-1 transcription [29]. This is due, in part, to the inabil-
ity of TNF to activate the ERK pathways in these c...
Báo cáo y học: "Autoantibody profiling for the study and treatment of autoimmune disease" docx
... tag. Bead
and tag systems are currently limited by the relatively small
numbers of addressable elements available.
Autoantibody profiling using antigen microarray technol-
ogy does not provide ... autoantibody profiling: selected published studies
Antigens Estimated
tested in capacity
System Assay format Detection citation(s) per array Comments Reference
Antigen microarrays Robotic att...