Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
Báo cáo y học: "Garden of therapeutic delights: new targets in rheumatic diseases" pptx
... block intracellular enzymes that control signaling pathways. Inhibitors of tyrosine kinases expressed in lymphocytes, such as spleen tyrosine kinase and Janus kinase, are being tested in autoimmune ... few key cytokine targets are discussed. Review Garden of therapeutic delights: new targets in rheumatic diseases Jean M Waldburger and Gary S Firestein Division of Rheum...
Ngày tải lên: 09/08/2014, 01:22
Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"
... were observed in response to p-synephrine or p-synephrine in combination with naringin and hes- peridin (Table 2). p-Synephrine differs from ephedrine in that it has a hydroxyl group on the ... self-report ratings of symp- toms increases confidence in the safety of the combi- nation as well as in the blinding procedure used in this study. Strengths of the study are the u...
Ngày tải lên: 25/10/2012, 11:04
Báo cáo y học: "Characterization of erythrovirus B19 genomes isolated in liver tissues from patients with fulminant hepatitis and biliary atresia who underwent liver transplantation"
... indicate the difficulty in amplifying the sequences in these re- gions. In our study, we attempted to amplify each ex- tremity, but failed. Interestingly, phylogenetic analysis based on the NS1 ... in 5 out of 6 isolates belonging to group 3, the amino acid at position 183 substi- tuted to alanine. Figure 1. Phylogram generated by neighbor-joining analysis of genetic dis...
Ngày tải lên: 26/10/2012, 10:03
Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"
... by silver staining on polyacrylamid gel. Statistical Analysis Allele frequencies were determined by gene counting and compared using the א² test. The data was analysed using SPSS 12.0 software. ... characterized by a rise of HDL and lowering of LDL, triglycerides, and insulin [5]. In addition, transgenic expression of an activated PPARδ in mice conferred resistance to obesity a...
Ngày tải lên: 31/10/2012, 17:03
Tài liệu Báo cáo Y học: Prediction of protein–protein interaction sites in heterocomplexes with neural networks ppt
... recently, methods were devised for predicting residues involved in protein interaction s ites in the absence of any structural reports. By analysing hydrophobicity distribution, linear stretches of ... some of the complexes or by other experimental means. CONCLUSIONS We have analysed the possibility of predicting the residues forming part of protein–protein interacting surfaces...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: Induction of (2¢)5¢)oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide docx
... (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢- linked oligoadenylates, termed (2–5)A ... again. Higher concentrations of LPS (10 lgÆmL )1 ) caused a lower effect on the (2–5)A synthesizing activity in S. domuncula. Despite the initially high (2–5)A synthesizing activity in ti...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: Analyses of the CYP11B gene family in the guinea pig suggest the existence of a primordial CYP11B gene with aldosterone synthase activity docx
... lower binding affinity of CYP11B1 to adrenodoxin when compared with CYP11B2. CYP11B1 has a tryptophan at position 366 while all other proteins of the CYP11B family including CYP11B2 of the guinea ... decrease in the activity for the 11b-hydroxylase, CYP11B1. Intriguingly, however, the 11b-hydroxylase activity of the aldosterone synthase CYP11B2 was basically unaffected whereas the 18...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: Formation of aberrant phosphotau fibrillar polymers in neural cultured cells doc
... been found associated in vivo with NFT [27] and it is able to modify in a way that results in the in vitro assembly of PHF like filaments [17]. Interestingly, it has been recently published that lipid peroxidation ... results in the hyperphosphorylation of tau protein, as determined by its change in electrophoretic mobility a nd its reaction with Ab 7.51, an antibody that recog...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells potx
... mode of action of Zn in induction of apoptosis remains to be unclear. In this study, we investigated the molecular mechanism underlying the mode of action of the induc- tion of apoptosis by elevation ... family of cysteine proteases, play a pivotal role in the execution of apoptosis [26]. We therefore examined the involvement of caspases in the apoptosis induced by P...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Activation of a covalent outer membrane phospholipase A dimer pptx
... This strongly suggests that the type of substrate in uences dimerization thereby indirectly in uencing binding of the catalytic calcium for wild-type OMPLA. Subsequently, it was investigated ... determined in kinetic assays. Catalytic calcium binding was determined in both wild-type OMPLA and the covalent OMPLA dimer in the kinetic assay, in which the mole fraction of substrat...
Ngày tải lên: 24/03/2014, 03:21