... responses. Furthermore, immune complexes of ANAscan drive the production of proinflammatory cytokines, inducing the ‘interferon signature’, and intensifying disease. Together, thesefindings point to ... entirety of the immune system. Some of these maybe genetically determined, whereas others arise secondarily in response to events such as infection. Not surprisingly,delineation of these disturbances ... pathways suchas transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that moleculesinducing autoimmunity have intrinsic immunologic activity andmay serve...