Báo cáo y học: "Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept" pot

... protection reported in clinical trials are corroborated by changing levels of circulating COMP. Rheumatoid arthritis patients commencing treatment with infliximab (N= 32) or etanercept (N = 17) were monitored ... ame- liorating inflammation [7]. In subsequent trials, the effect of COMP = cartilage oligomeric matrix protein (thrombospondin-5); CRP = C-reactive protein;...

Ngày tải lên: 09/08/2014, 01:21

... previously described, staining of human synovial tissue with haematoxylin and eosin showed an increase in the number of cell layers of the synovial lining of RA patients (Figure 1). E- cadherin staining ... E-cadherin in syn- ovial tissue [29], our study is in line with a study by Trollmo and colleagues [30], describing E-cadherin expression in the lining layer of healthy synovi...

Ngày tải lên: 09/08/2014, 08:23

... bioactivity in rheu- matoid arthritis (RA) patients treated with infliximab. Using this bioassay three patterns were observed and linked to the clinical response in the 20 patients with a 1-year ... The combination of tumor necrosis fac- tor alpha blockade with interleukin-1 and interleukin-17 block- ade is more effective for controlling synovial inflammation and bone res...

Ngày tải lên: 09/08/2014, 06:22

... (SP) with inflammatory cytokines. It is well known that proinflammatory cytokines have a fundamental role in the development and maintenance of RA and other inflammatory diseases. Cytokines such ... evidence for the involvement of neuropeptides in inflammatory diseases has focused predominantly on a proinflammatory role for SP [15,17], as well as an immuno- modulatory role for neuropept...

Ngày tải lên: 09/08/2014, 06:23

... identifying the detected autoantigens by mass spectrometry, we investigated the contribution of citrullination to autoantigenicity by using a recombinant protein with or without citrullination ... tissues of patients with rheumatoid arthritisCitrullination of F-actin capping protein α-1 subunit (CapZα-1) in syno- vial tissues of patients with rheumatoid arthritis. The e...

Ngày tải lên: 09/08/2014, 08:23

... and Pyk2 associate with the cytoskeleton and with integrin-signaling complexes by binding to Src kinase and paxillin [2-5]. FAK is rapidly tyrosine phosphorylated on cell adhesion, creating a high-affinity ... 3h). pPaxillin immunostaining Paxillin is a multidomain adaptor protein that interacts with sig- naling proteins such as FAK, Pyk2, Src and PLCγ [6,33]. The phosphorylation of p...

Ngày tải lên: 09/08/2014, 10:21

... function is highly dependent upon current levels of inflammation. In healthy people, the inflammatory response elicited by vaccination is sufficient to temporarily (and reversibly) impair endothelial ... Reduction of inflammation using anti-TNF therapy in RA is rapidly (although transiently) followed by improvement of the endothelial function [8]. Interestingly, high-grade systemic inflam...

Ngày tải lên: 09/08/2014, 10:22

... procedures: dorsal tenosynovectomy, flexor tenosynovectomy or arthroplasty of the metacarpophalangeal joints. Tissue was collected into DMEM (PAA Laboratories, Coelbe, Germany) containing heat-inactivated ... hypoxic incubator with inflow and outflow valves (Wolf Laboratories Limited, York, UK). Oxygen concentrations were continuously measured with a built -in oxygen sensor and the per...

Ngày tải lên: 09/08/2014, 14:20

... chronic inflammatory disease characterized by polyarticular joint inflammation, synovial hyperplasia, and cartilage and bone destruction, with subse- quent joint deformities. The inflammatory synovial ... leukocytes in rheumatoid joints [4], and have destructive potential by secret- ing proteases and reactive oxygen species and by promoting synthesis of matrix metalloproteinases [5,...

Ngày tải lên: 09/08/2014, 14:21

... anti- body positivity in infliximab -treated rheumatoid arthritis patients. (a) Cir- culating plasmacytoid dendritic cell (pDC) levels in rheumatoid arthritis (RA) patients after 14 weeks of infliximab ... levels in rheumatoid arthritis (RA) patients treated by infliximab with anti- nuclear antibody (ANA) (n = 10) or without ANA production (n = 10), in...

Ngày tải lên: 09/08/2014, 14:22