Báo cáo y học: "Rituximab in lupus Robert Eisenberg " pdf

... expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int Immunol 2001, 13:1583-1593. 9. Youinou P, Lydyard PM, Mageed RA: B cells underpin lupus immunopathology. Lupus ... mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J Exp Med 1999, 189:1639-1648. 7. Lipsky PE: Systemic lupus ery...

Ngày tải lên: 09/08/2014, 01:21

... pathway and which B-cell subsets are involved in developing autoimmunity, by using BAFF-Tg mice and other genetically engineered mice. Interestingly, they found that CD40-dependent germinal center ... vascular biology and the immune system. New advances in treating lupus After the demonstration that mycophenolate mofetil is more effective than intravenous cyclophosphamide in inducing...

Ngày tải lên: 09/08/2014, 10:20

... many different cytokines may be involved. Second, although many cytokines may be involved in the pathogenesis of SLE, research thus far has concentrated on a small group of cytokines, notably tumour ... meeting showed the breadth of interest in the role played by different cytokines in SLE. A large amount of work in mice, and a smaller body of evidence on the effects of anticytokine a...

Ngày tải lên: 09/08/2014, 01:22

... from Pharmingen-Becton Dickin- son (San Diego, CA, USA). Biotinylated antibodies were detected using an allophycocyanin-conjugated streptavidin antibody (Pharmingen-Becton Dickinson). Staining was ... units. The analysis was done blind and 50 glomeruli per section were analysed. Flow cytometry Flow cytometry was performed using a three colour staining on spleen cells and thymocytes and analys...

Ngày tải lên: 09/08/2014, 07:20

... transfection or DNA-binding proteins [11,12]. Within the context of SLE, these findings suggest that molecules inducing autoimmunity have intrinsic immunologic activity and may serve as adjuvants ... human leukocyte antigen; IFN = interferon; IRF = interferon regulatory factor; ITGAM = integrin alpha(M); MBL = mannose binding lectin; PDCD = programmed cell death; PTPN = protein tyrosine phosp...

Ngày tải lên: 09/08/2014, 11:20

... complement system, for many years only assessed as a measure of immune complex-mediated activation, is increasingly recognized to play a prominent role in many lupus- associated inflammatory states, including ... Osterland CK, Yeadon C, Smith CD: A long-term study of hydroxychloroquine withdrawal on exacer- bations in systemic lupus erythematosus. The Canadian Hydroxychloroquine Study...

Ngày tải lên: 09/08/2014, 14:22

... decrease in CD19 + CD27 + memory B cells not only in the PB but also in the BM of RA patients who subsequently responded to rituximab. In contrast, memory B cells in nonre- sponders remained stable ... collected in the lymphocyte gate for analysis in an Epics Elite flow cytometer (Coulter, Miami, FL, USA). Lymphocyte subsets were defined as follows: naïve B cells, CD19 + CD27 -...

Ngày tải lên: 09/08/2014, 14:22

... anti-citrullinated protein antibodies), which can be found already in the preclinical phase of the disease; the presence of lymphocyte aggre- gates containing B cells, which are often surrounded by large numbers ... cytotoxicity plays a dominant role in B cell depletion in the splenic marginal zone B cell compart- ment, whereas Fc receptor mediated mechanisms (like antibody-dependent ce...

Ngày tải lên: 09/08/2014, 14:22

... respectively. Interestingly, an increase in virological response over time after the discontinuation of thymosin could be observed (p=0.02) [40]. The doses of thymosin α-1 in this meta-analysis are ... nucleoside analogues, lamivudine and adefovir dipivoxil. The immunomodulators act by promoting cytotoxic T cell activity for lysis of infected hepatocytes and by stimulating cytokine pr...

Ngày tải lên: 02/11/2012, 11:17

... intermediate intermediate No intermediate intermediate intermediate yes DNA arrays na intermediate intermediate no high high low yes Indirect methods Viral load na na na yes intermediate low low yes ... high intermediate low no LiPA 5% low low-intermediate yes intermediate low low yes Florescence nd intermediate intermediate no intermediate intermediate intermediate yes MALDI-TOF <...

Ngày tải lên: 03/11/2012, 09:41