Báo cáo y học: " Autoantibodies in vasculitis" pptx

... bactericidal/permeability- increasing protein in patients with cystic fibrosis. Q J Med 1996, 89:259-265. 38. Kobayashi O: Clinical role of autoantibody against bacterici- dal/permeability-increasing protein in chronic ... immunomodulating therapy. Complex interactions between autoantibodies, endothelial cells and inflammatory cells, including neutrophils, are likely to act in concert...

Ngày tải lên: 09/08/2014, 01:21

... to citrullinated peptides in RA patients. Further studies [23,24] focussed on an involvement of peptidylarginine deiminases citrullinating enzymes (encoded by PADI genes). In a Japanese case-control linkage ... antigens by enzymatic activity (deiminases), and subsequent immune-mediated destruction of the synovium [9]. Regulation of peptidyl arginine deiminase (PADI) activity appears also...

Ngày tải lên: 09/08/2014, 06:22

... its (already low) residual electron transfer activity is not maintained by the neighbouring tyrosine, while the W121F /Y1 22F mutant activity may be viewed as a commitment of the tyrosine residue ... potential entry site: mutations in an exposed tyrosine (Y2 26F; see Table 1) and in a histidine (H119N; Table 2) show wild-type kinetics. Biphasic steady-state kinetics Non-linear kinetics ha...

Ngày tải lên: 22/02/2014, 07:20

... recognized only one epitope on CD69. Interestingly, the amino acid sequence of this main epitope (EKNLYWI) is highly homologous to a part (EKRLYWI) of low-density-lipoprotein-receptor-related protein 2 ... arthritis; SLE = systemic lupus erythematosus; SSc = systemic sclerosis. Competing interests None declared. Acknowledgements This work was supported by in part by grants -in- aid from the...

Ngày tải lên: 09/08/2014, 01:21

... more of the following criteria: fulfilling the clinical symptom of inflammatory back pain, being positive for HLA-B27, or showing evidence of sacroiliitis by imaging [11]. Analyzing 350 referred ... respectively) of clinical symptoms. Andrei Calin, of Bath, UK, had started this kind of work in the early 90s with the definition of the Bath Ankylosing Spondylitis Disease Activity Index (BASDA...

Ngày tải lên: 09/08/2014, 01:22

... [23]. This link between proinflammatory cytokines and osteoclast formation most likely explains why cytokine-targeted therapy, particularly blockade of TNF, is highly effective in retarding structural damage ... lineage types such as Kupffer cells in the liver or microglia in the brain. It is not fully clear whether some monocytes entering an inflamed joint are already committed to the...

Ngày tải lên: 09/08/2014, 01:22

... from Pharmingen-Becton Dickin- son (San Diego, CA, USA). Biotinylated antibodies were detected using an allophycocyanin-conjugated streptavidin antibody (Pharmingen-Becton Dickinson). Staining was ... units. The analysis was done blind and 50 glomeruli per section were analysed. Flow cytometry Flow cytometry was performed using a three colour staining on spleen cells and thymocytes and analys...

Ngày tải lên: 09/08/2014, 07:20

... sera. We examined whether the binding of DNA to RPA can inter- fere the reactivity of anti-RPA autoantibodies by incubating affinity-purified RPA with ssDNA, dsDNA, or dsRNA before antibody binding. ... Macdonald-Bravo H: Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 1987, 326:515-517. 5. Reeves WH, Narain S, Satoh M: Autoantibodies in systemic lupus erythematosus...

Ngày tải lên: 09/08/2014, 08:22

... is included in the study. Results showed a 5% to 10% improvement in prediction using combined versus single biomarkers – a definite improvement on existing biomarkers. This is an important principle ... efficacy of intervention and diagnostic) recommendations [4]. As the authors comment, the use of the current suboptimal method for determining OA radiographically is a weakness and only ea...

Ngày tải lên: 09/08/2014, 14:22

... SBF contains the DNA-binding pro- tein Swi4, while MBF contains the Swi4-related DNA- binding protein Mbp1, and both factors contain the regu- latory protein Swi6, which binds directly to Swi4 ... measured using microarrays. In order to select genes specifically induced by Cln3 (or by cell cycle entry) as opposed to those induced by stress or by galac- tose, we used five slightly different...

Ngày tải lên: 09/08/2014, 20:22