Báo cáo y học: " Systemic lupus erythematosus: a BLySful, yet BAFFling, disorder" pps

... may have profound ramifications for antagonist therapy, since a clinically effi- cacious BLyS antagonist may need to be directed against not just BLyS but against APRIL as well. Are all SLE patients ... 104:115-122. 17. Kayagaki N, Yan M, Seshasayee D, Wang H, Lee W, French DM, Grewal IS, Cochran AG, Gordon NC, Yin J, Starovasnik MA, Dixit VM: BAFF/BLyS receptor 3 binds the B cell survival...

Ngày tải lên: 09/08/2014, 01:21

... 36 years (range 14–54 years), and the mean disease duration before onset of SLE was 16 years (range 3–40 years). All patients had been treated with a mean of five disease-modify- ing antirheumatic ... anti-DNA antibodies, Ouchterlony's method for anti-extractable nuclear antigens (anti-ENA), and an ELISA for anti-histone, anti-Ro, anti-La, anti-SM, anti-RNP, anti-JO1, anti-Topo 1, and...

Ngày tải lên: 09/08/2014, 06:22

... clinical and laboratory findings. Am J Kidney Dis 1985, 6:59-63. 4. Li SL, Liou LB, Fang FT, Tsai WP: Symptomatic renal tubular acidosis (RTA) in patients with systemic lupus erythematosus: an analysis ... journal. Abbreviations RTA: renal tubular acidosis; SLE: systemic lupus erythematosus; SLEDAI: systemic lupus erythematosus disease activity index; TTKG: transtubular potassiu...

Ngày tải lên: 11/08/2014, 00:23

... Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Gunther G, Johnston I, Lanzavecchia A, Nagasaka T, Okada T, Vermi W, Winkels G, Yamamoto T, Zysk M, Yamaguchi Y, Scmitz J: BDCA-2, a ... Cella M, Jarrossay D, Facchetti F, Alebardi O, Nakajima H, Lanza- vecchia A, Colonna M: Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interfe...

Ngày tải lên: 09/08/2014, 01:21

... serological or clinical Abstract BLyS and APRIL are closely related members of the TNF ligand superfamily. These cytokines individually may contribute importantly to the development and maintenance ... that although belimumab and atacicept each binds to and neutralizes BLyS, their res- pec tive biologic activities importantly diff er. Belimumab has no APRIL-neutralizing capacity, whereas...

Ngày tải lên: 12/08/2014, 12:20

... mitochondrial membrane potential, may have increased levels of cell surface MHC, are easily damaged by free radicals (including excessive reactive oxygen intermediates), and may show increased levels ... O'Reilly LA, Kuida K, Strasser A: Transforming growth factor beta-dependent sequential acti- vaiton of Smad, Bim, and caspase-9 mediates physiological approaches in gastric epithelial...

Ngày tải lên: 11/08/2014, 10:23

... Real-time quantitative PCR. Methods 2001, 25: 383-385. 43. Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A, Ishizaka A, Abraham ... therapy. In the present study HMGB1 was analysed in a semi-quantita- tive way using conventional manual microscopy. Computer- ised image analysis was not an option because this technology d...

Ngày tải lên: 09/08/2014, 10:23

... receiver operating characteristic; rSLEDAI: renal Systemic Lupus Erythematosus Disease Activity Index; SLE: systemic lupus erythematosus; SLEDAI: Systemic Lupus Erythematosus Disease Activity Index; ... nephritis; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index. a African American/Hispanic/Caucasian/other. b Ethnicity of three additional non-LN systemic lupu...

Ngày tải lên: 09/08/2014, 14:22

... 96:443-451. 7. Kasahara Y, Yachie A, Takei K, Kanegane C, Okada K, Ohta K, Seki H, Igarashi N, Maruhashi K, Katayama K, Katoh E, Terao G, Sakiyama Y, Koizumi S: Differential cellular targets of Epstein-Barr ... research and analyzed data; ES and FB analyzed data; SC and GM were responsible for patient care and provided clinical information; AG, CM, SR, and MTS analyzed data; SAP and PPP p...

Ngày tải lên: 10/08/2014, 23:21

... of acute leukemia, lym- phoma, plasma cell dyscrasia, or immun ophenotypic changes associated with myelodysplasia. Blast cells, mono- cytes, myeloid cells, and lymphocytes were not relatively increased ... with anemia and thrombocytopenia of two months duration. The patient underwent physical examination, bone marrow aspiration and biopsy, chest X-ray, acid-fast bacilli stain, computed tomogr...

Ngày tải lên: 11/08/2014, 14:20