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Báo cáo y học: "Smoking–gender interaction and risk for rheumatoid arthritis" pot

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Báo cáo y học: "Smoking–gender interaction and risk for rheumatoid arthritis" pot

... case–control study was conducted to investigatethe relationship between smoking and rheumatoid arthritis, and to investigate formally the interaction between sex, smoking, and risk for developing rheumatoid ... articleSmoking–gender interaction and risk for rheumatoid arthritisEswar Krishnan1, Tuulikki Sokka2,3, Pekka Hannonen21Department of Medicine, Stanford University, Palo Alto, California, USA2Jyväskylä ... H: Smoking, rheumatoid factor isotypes and severity of rheumatoid arthritis. Rheumatology (Oxford) 2000,39:1202-1205.10. Dai WS, Gutai JP, Kuller LH, Cauley JA: Cigarette smoking and serum sex...
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Báo cáo y học: "MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin α5β" pdf

... 2.0Software (Clontech), developed specifically for analysis ofthe Atlas cDNA expression arrays. All spots were individu-ally checked by hand to ensure accuracy of the detectionmethod. A dot was considered ... inflam-mation. In support of this hypothesis, Choe and colleaguesshowed that innate immune functions via TLR-4 mayperpetuate inflammatory mechanisms and bypass the need for IL-1 in chronic joint inflammation. ... is supported by a grant from the French Ministry of Research and Technologies, and VAD, by grants from Région Alsace, Amgen, and Wyeth Lederle. This work was supported in part by a grant from...
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Báo cáo y học: "Interleukin-18: a therapeutic target in rheumatoid arthritis" potx

... synergy across distinct tissueevents. In particular, cytokine mediated pathology may bedistinct in cartilage and bone as opposed to synovialtissue or draining lymph node. For many given cytokines,establishing ... tissue cell lineages including keratinocytes,osteoclasts and chondrocytes [2]. Importantly, IL-18 oftenacts in synergy rather than independently, and for someactivities it remains unclear whether ... unravel functional pleiotropy and redundancy for a cytokine, and explore patient variation inexpression and regulation prior to ‘rational’ progress.IL-18, originally described as IFNγ inducing...
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Báo cáo y học: " Review Cells of the synovium in rheumatoid arthritis" pot

... number not for citation purposes)TLR ligands, including lipopolysaccharide, mycobacterial and yeast products, proinflammatory cytokines such as IL-1, TNF and IL-6, as well as other potentially harmful ... by similar and simultaneous triggers to NF-κB.Introduction Rheumatoid arthritis (RA) is characterized by systemic and synovial tissue chronic inflammation, and by bone and cartilageerosion and ... generally found closely associated withT lymphocytes [16,90,93], which may signal the alternateNF-κB pathway through proinflammatory cytokines, CD154(CD40L) and lymphotoxin-β [111,112].Synthesis:...
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Báo cáo y học: "Review Cells of the synovium in rheumatoid arthritis" pot

... isupregulated by inflammatory cytokines in both chondrocytes and synovial cells and by hypoxia [166,167], and Vegfbknockout mice are protected against synovial angiogenesis inthe CIA and AIA models ... (RANKL), which is produced by synoviocytes and T cells in RA synovium [179] and mediates osteoclastdifferentiation and activity, may partly account for the capacityof IL-17 to induce bone destruction ... procollagenases and is produced by boththe synovium and chondrocytes in response to inflammatorycytokines [38]. In contrast, MMP-14, produced principally bythe synovial tissue, is important for synovial...
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Báo cáo y học: "Recent developments in the immunobiology of rheumatoid arthritis" potx

... IL-1-induced IL-6 and leukemia inhibitory factorproduction by rheumatoid arthritis synoviocytes and its regu-lation by Th2 cytokines. J Immunol 1998, 161:409-414.40. Ziolkowska M, Koc A, Luszczykiewicz ... Ross EJ, Lee CY, Akbar AN, LordJM, Gordon C, Buckley CD, Salmon M: Early rheumatoid arthri-tis is characterized by a distinct and transient synovial fluidcytokine profile of T cell and stromal ... Bayry J, Siberil S, Triebel F, Tough DF, Kaveri SV: RescuingCD4+CD25+regulatory T-cell functions in rheumatoid arthritisby cytokine-targeted monoclonal antibody therapy. DrugDiscov Today...
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Báo cáo y học: "Developments in the scientific understanding of rheumatoid arthritis" pot

... scientific understanding of rheumatoid arthritisJörg J Goronzy and Cornelia M WeyandLowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, ... KJ, Kent PD, Frye RL, Lymp JF, Kopecky SL, GoronzyJJ, Weyand CM: Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case controlstudy. Arthritis Res ... & Therapy Vol 11 No 5 Goronzy and WeyandPage 4 of 14(page number not for citation purposes)Figure 2Central and peripheral T-cell selection and differentiation as risk factors for synovial...
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Báo cáo y học: "Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients"

... Hamburg-Eppendorf, Germany. 3. Department of Microbiology and Immunology, University Hospital Hamburg-Eppendorf, Germany. 4. Department of Anatomy II: Experimental Morphology, University Hospital Hamburg-Eppendorf, ... airways with P. aerugi-nosa is the leading cause of morbidity and mortality in the majority of CF patients (1). This pathogen colonises the airways and lungs often in the late teens or early ... lectins –I and –II and their interaction with human airway cilia. J Laryngol Otol 2005; 119: 595-599. 16. Sofer D, Gilboa-Garber N, Belz A, Garber NC: “Subinhibitory” erythromycin represses...
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Báo cáo y học: "Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine" docx

... Patients were evaluated by aresearch psychiatrist weekly during the first 6 weeks,biweekly for the next 4 weeks, and weekly for the finalYang et al. Annals of General Psychiatry 2010, 9:10http://www.annals-general-psychiatry.com/content/9/1/10Page ... dosages were 10 mg/day for the first week, 20 mg/day for weeks 2 to 4, 40 mg/day for weeks 4 to 8, and 60 mg/day for weeks 5 to 12. Thedose was increased to meet the target only if the patienttolerated ... hypersom nia and insom-nia, and a greater severity of depressive and anxietysymptoms [8,9], as well as increased suicide rates[10-12] among depressed patients. In addition, insomnia and hypersomnia...
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Báo cáo y học: " What is MRI bone oedema in rheumatoid arthritis and why does it matte" ppt

... might appear astype B synoviocytes and promote synovitis [23]. Alternatively,they could travel via the systemic circulation to thesubchondral bone marrow and initiate inflammatory and pre-erosive ... unusual sensitivity to TNFα. (b) Stem cells differentiate into fibroblast-like cells and travel via the circulation tosynovial membrane to become type B synoviocytes - here they mediate formation of ... widespread and relatively common in early and late disease and tied to the development of long termjoint damage. Before the advent of MRI, this process sited inthe subchondral bone was unsuspected and...
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