Báo cáo y học: "Smoking–gender interaction and risk for rheumatoid arthritis" pot

... case–control study was conducted to investigate the relationship between smoking and rheumatoid arthritis, and to investigate formally the interaction between sex, smoking, and risk for developing rheumatoid ... article Smoking–gender interaction and risk for rheumatoid arthritis Eswar Krishnan 1 , Tuulikki Sokka 2,3 , Pekka Hannonen 2 1 Department of Medicine, Stanf...

Ngày tải lên: 09/08/2014, 01:21

... 2.0 Software (Clontech), developed specifically for analysis of the Atlas cDNA expression arrays. All spots were individu- ally checked by hand to ensure accuracy of the detection method. A dot was considered ... inflam- mation. In support of this hypothesis, Choe and colleagues showed that innate immune functions via TLR-4 may perpetuate inflammatory mechanisms and bypass the need for...

Ngày tải lên: 09/08/2014, 06:22

... synergy across distinct tissue events. In particular, cytokine mediated pathology may be distinct in cartilage and bone as opposed to synovial tissue or draining lymph node. For many given cytokines, establishing ... tissue cell lineages including keratinocytes, osteoclasts and chondrocytes [2]. Importantly, IL-18 often acts in synergy rather than independently, and for some activit...

Ngày tải lên: 09/08/2014, 06:22

... number not for citation purposes) TLR ligands, including lipopolysaccharide, mycobacterial and yeast products, proinflammatory cytokines such as IL-1, TNF and IL-6, as well as other potentially harmful ... by similar and simultaneous triggers to NF-κB. Introduction Rheumatoid arthritis (RA) is characterized by systemic and synovial tissue chronic inflammation, and by bone and...

Ngày tải lên: 09/08/2014, 10:20

... is upregulated by inflammatory cytokines in both chondrocytes and synovial cells and by hypoxia [166,167], and Vegfb knockout mice are protected against synovial angiogenesis in the CIA and AIA models ... (RANKL), which is produced by synoviocytes and T cells in RA synovium [179] and mediates osteoclast differentiation and activity, may partly account for the capacity of IL-17...

Ngày tải lên: 09/08/2014, 10:21

... IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regu- lation by Th2 cytokines. J Immunol 1998, 161:409-414. 40. Ziolkowska M, Koc A, Luszczykiewicz ... Ross EJ, Lee CY, Akbar AN, Lord JM, Gordon C, Buckley CD, Salmon M: Early rheumatoid arthri- tis is characterized by a distinct and transient synovial fluid cytokine profile of...

Ngày tải lên: 09/08/2014, 10:22

... scientific understanding of rheumatoid arthritis Jörg J Goronzy and Cornelia M Weyand Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, ... KJ, Kent PD, Frye RL, Lymp JF, Kopecky SL, Goronzy JJ, Weyand CM: Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control st...

Ngày tải lên: 09/08/2014, 14:22

... Hamburg-Eppendorf, Germany. 3. Department of Microbiology and Immunology, University Hospital Hamburg-Eppendorf, Germany. 4. Department of Anatomy II: Experimental Morphology, University Hospital Hamburg-Eppendorf, ... airways with P. aerugi- nosa is the leading cause of morbidity and mortality in the majority of CF patients (1). This pathogen colonises the airways and lungs often i...

Ngày tải lên: 03/11/2012, 11:48

... Patients were evaluated by a research psychiatrist weekly during the first 6 weeks, biweekly for the next 4 weeks, and weekly for the final Yang et al. Annals of General Psychiatry 2010, 9:10 http://www.annals-general-psychiatry.com/content/9/1/10 Page ... dosages were 10 mg/day for the first week, 20 mg/day for weeks 2 to 4, 40 mg/day for weeks 4 to 8, and 60 mg/day for weeks...

Ngày tải lên: 08/08/2014, 23:21

... might appear as type B synoviocytes and promote synovitis [23]. Alternatively, they could travel via the systemic circulation to the subchondral bone marrow and initiate inflammatory and pre- erosive ... unusual sensitivity to TNFα. (b) Stem cells differentiate into fibroblast-like cells and travel via the circulation to synovial membrane to become type B synoviocytes - here they medi...

Ngày tải lên: 09/08/2014, 08:23