Báo cáo y học: "CD44 in rheumatoid arthritis" pot

... homology to other HA-binding link proteins. The two basic clusters (gray segments in Fig. 1A, inset a) are involved in HA binding: the first (located inside the link module and overlapping the ... to HA binding are also shown in Fig. 1A, inset a. Cys-266 in the transmembrane domain (Fig. 1A, inset b) is important for HA binding in Jurkat cells. Cys-266 and Cys-275 can be used for pa...

Ngày tải lên: 09/08/2014, 01:21

... cause proteins to become non-enzymatically damaged by glyoxidation. This process, which involves primarily lysine and arginine residues, ultimately results in the generation of advanced glycation ... the synthesis of matrix components including proteoglycans by chondro- cytes. In particular, NO and O 2 seem to inhibit type II collagen and proteoglycan synthesis and the sulfation of newly...

Ngày tải lên: 09/08/2014, 01:24

... mg/week in the original Table 2 Treatment terminations for ineffectiveness in original and re-employed methotrexate therapies Re-employed course Total No inefficacy Inefficacy Original course No inefficacy ... g/day in original courses and 2.1 ± 0.5 g/day in re- employed courses (P = 0.30, by Wilcoxon test). Among patients with ineffective original sulfasalazine therapies (n = 16), do...

Ngày tải lên: 09/08/2014, 07:20

... to a synthetic blockade of the second step of the enzyme P450c17, again induced by inflammatory cytokines such as IL1β and TNF. Increased DHEAS levels during treatment with TNF antagonists in active ... relationships Activation of the hypothalamus-pituitary-adrenal axis by pro- inflammatory stimuli and chronic stress leads to a parallel decrease in hypothalamus-pituitary-gonadal axis acti...

Ngày tải lên: 09/08/2014, 14:22

... fluorescein isothiocyanate- conjugated anti-mouse antisera for 30 minutes at 4°C. Stained cells were fixed and 1 × 10 4 viable cells were analysed by flow cytometry using standard settings. Induction ... G 2 / M phase, indicating that the cell population remained highly synchronised. Cell cycle analysis after 42 and 48 hours confirmed an increase of RASFs in G 0 /G 1 phase, indicating tha...

Ngày tải lên: 09/08/2014, 01:22

... Ceuppens JL, Luyten FP: Bone morpho- genetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. ... of hypotheses to explain the pathogenesis of chronic rheumatoid arthritis (RA), including the interesting new study by Raza and colleagues [1], has been a wondrous adventure. Virtua...

Ngày tải lên: 09/08/2014, 06:23

... ultimately, of the upregulation of proinflammatory cyto- kines [19,20]. By whichever means they themselves become activated, they induce a plethora of inflammatory products, including degradative enzymes, ... inflammatory events leading to pain, swelling due to synovial thickening and effusion, and stiffness of the joints. While initially individual signs and symptoms, such as swollen joint c...

Ngày tải lên: 09/08/2014, 01:22

... indicate that genetic regulation involving the TNF-RII gene may play some role in determining circulating levels in RA. Competing interests The author(s) declare that they have no competing interests. Authors' ... polymorphism results in a nonconservative amino acid substitution in which arginine, with a highly basic side chain, replaces methionine, which has a nonpolar side chai...

Ngày tải lên: 09/08/2014, 07:20

... ontology (GO) categories are shown. Figure 3 Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7Hematoxylin/eosin staining of the synovial membrane of patients 1 to 7. Original ... with rheumatoid arthritis. This was done by applying microarray technology on multiple synovial biopsies obtained from the same knee joints. In this way the relative levels of intra-patient...

Ngày tải lên: 09/08/2014, 07:20

... physiology and pathology. Introduction In patients with rheumatoid arthritis (RA), joint pathology is mediated by typical changes in the synovial tissue. Hyperpla- sia of the synovial lining layer, infiltration ... purposes) lage by the release of inflammatory cytokines and destructive proteases [2]. Increases in knowledge about inflammatory cytokines and cytokine networks in chroni...

Ngày tải lên: 09/08/2014, 07:20