Báo cáo y học: "Aggrecanases and cartilage matrix degradation" potx
Báo cáo y học: "Aggrecanases and cartilage matrix degradation" potx
... Design and synthesis of a series of (2R)-N(4)- hydroxy-2-(3-hydroxybenzyl)-N(1)-[(1S,2R)-2-hydroxy-2,3- dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable ... Number 061709 and NIH Grant AR40994. References 1. Hinegård D, Lorenzo P, Sanxe T: Matrix glycoprotein, proteogly- cans, and cartilage. In Kelly’s Textbook of Rheumatology. Edited by...
Ngày tải lên: 09/08/2014, 01:21
Báo cáo y học: "Isotretinoin and psychopathology: a review" potx
... use and psychiatric symptoms. How- ever, given all the evidence, the association between isotretinoin use and psychopathology seems most likely to be justified. The multiformity of reported psychiatric adverse ... Isotretinoin therapy and depression: evidence for an association. Ir J Psych Med 1998, 15:58-60. 24. Barak Y, Wohl W, Greenberg Y, Bar Dayan Y, Friedman T, Shoval G, Knoble...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: "Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells" potx
... directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte- bral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 2007, 9:R83. 40. Kandel ... WB, Luyten FP, Erlacher L: Cartilage- derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis" pps
... contributions US and NS performed the Affymetrix chip analysis. US, NS and CP analysed the MMP, cathepsin and cytokine expres- sion by real-time PCR. MH performed the zymography, the MMP activity assay and ... on day 7 at the mRNA level in our study. The biological activity of the proteinases can be regulated transcriptionally and post-transcriptionally by different TIMPs and by a...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... identical and 91% similar amino acids to human YKL40, and was only 48% identical to human YKL39. In spite of intense primer design and PCR analysis, it was not possible to obtain any fragments for YKL39 ... oligo(dT)-coated beads (Dynabeads; Dynal, Oslo, Norway) according to the manufacturer's instructions, and was quantified and tested for quality by measurement of the optical...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Relaxin and β-estradiol modulate targeted matrix degradation in specific synovial joint fibrocartilages: progesterone prevents matrix loss" doc
... specificity in the responses of var- ious cartilages and fibrocartilages to modulation of matrix loss by relaxin and β-estradiol. Excessive degradation of collagen and GAGs by relaxin and/ or β-estradiol ... proteinases, primarily those belonging to the matrix metalloproteinase (MMP) family of enzymes [2]. This normal tissue turnover is regulated by many local and systemic agents...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: "Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis" pot
... at days 0, 1, 3, 5, 7, 8, 10, 12, and 14. Hydroxypro- line release was assayed as a measure of collagen degrada- tion, and glycosaminoglycan release was assayed as a measure of proteoglycan degradation ... synergistically induces the synthesis and activation of pro-collagenases, causing almost complete resorption of human and bovine nasal cartilage in a short assay period [19,20]. N...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf
... in human dermal and synovial fibroblasts upon exposure to culture supernatant and whole cell lysates of S. aureus. Human dermal and synovial fibroblasts treated with cell lysate and filtered culture ... of an inflammatory cytokine-mediated pathway in the observed induction of MMPs by S. aureus. S. aureus culture supernatants and cell lysates have a wide variety of proteins, and id...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: " Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc" pot
... degeneration. MMP-10 (also known as stromelysin-2) is a member of the stromelysin family of enzymes, along with MMP-3 (stromelysin- 1) and MMP-11 (stromelysin-3). This family of enzymes exhibit a wide range of ... expres- sion and activity of a range of matrix- degrading enzymes in IVD degeneration, including the matrix metalloproteinase (MMP) [8-11] and more recently ADAMTS (a disin...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia" potx
... activity and proteolysis of the extracellular matrix [7- 9]. MMPs are proteolytic enzymes, specifically endopepti- dases, whose catalytic mechanism involves a metal ion such as zinc (Zn 2+ ) and ... Metallopro- teinases, also called matrixins, include a large family of proteolytic enzymes, known as metzincin super-family. Their catalytic action is the degradation, mainly in neutral pH e...
Ngày tải lên: 10/08/2014, 10:20