Báo cáo y học: "A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritis" pptx

... data in a way that aids their interpreta-tion. Integrating various incompatible bioinformatics plat-forms is essential. Such efforts are currently under way bythe Interoperable Informatics Infrastructure ... cum calore et dolor]) as an entity using a singularrather than a plural noun, implying that it might be a singleprocess or a type of process. The avascular, alymphaticand aneural human OA-affected ... debate on OA or osteoarthrosis based on theCommentary A need for a ‘whole-istic functional genomics’ approach in complex human diseases: arthritisAshok R AminHospital for Joint Diseases/NYU...

Báo cáo y học: "The quest for a biomarker of circulating osteoclast precursors" docx

... rheumatoid arthritis patients and these cells displayan inflammatory phenotype characterized by increasedrelease of interleukin-1 and tumor necrosis factor followingexposure to lipopolysaccharide ... non-proliferative fraction based on analysis ofcarboxyfluorescein succinimidyl ester (CFSE)-labeled cells.The authors state that functional analysis of proliferation mayprovide a better tool for identification ... regarding the central importance of phagocytosisto human physiology, which culminated in a Noble Prize andlaid the groundwork for the field of innate immunity at theopening of the last century...

Báo cáo y học: "Preliminary evidence for a change in spectral sensitivity of the circadian system at night" potx

... couldmathematically represent both the pupil and iris. A rela-tive measurement, referred to as relative pupil area (rPA)was obtained by dividing the pupil area by the iris area.Only the rPA values ... shown that in macaque(and, therefore, probably in humans as well), photosensi-tive melanopsin-expressing RGCs have input to the lateralgeniculate nucleus (LGN), a major neural relay stationfrom ... the retino-hypothalamic tract changes throughout the 24-hourday. It is also believed that a combination of classical photoreceptors (rods and cones) andmelanopsin-containing retinal ganglion...

Báo cáo y học: "The need for prognosticators in rheumatoid arthritis. Biological and clinical markers: where are we now" potx

... treatment.Recent analyses in a large cohort of clinical trial patients haverevealed that baseline disease activity is already somewhatrelated to disease activity at 1 year of therapy, especially withmethotrexate ... Udagawa N, Takami M, KotakeS, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H,Morinaga T, Higashio K, Martin TJ, Suda T: Tumor necrosisfactor alpha stimulates osteoclast differentiation ... (RA) is characterized by many differentphenotypes. Joint involvement, although characteristicallysymmetrical, can range from a monoarticular pattern to a highly polyarticular pattern, and joint...

Báo cáo y học: "The need for intra aortic balloon pump support following open heart surgery: risk analysis and outcome" pdf

... threshold for intraoperati ve IABPinsertion.Ninety patients had intraaortic balloon inserted intrao-peratively with a mortality of 33.3%. We attempt to splitthe intraoperative IABP insertion patient ... 2ndgeneration in combination with vancomycin,through out the IABP support, was maintained.Statistical analysisCollection o f the data is served using the Patients Ana-lysis and Tracking System (PATS) ... syndrome. Prophy-lactic initiation of IABP treatment was not advocated in any of t he cases. A Datascope system (Datascope Corp,Paramus, NJ) was utilised. The IABP was introducedpercutaneously through...

Báo cáo y học: "Enhanced surveillance for childhood hepatitis B virus infection in Canada, 1999-2003"

... school-based vaccination strategies, as well as the increase in immigration flow and international adoptions, have changed the epidemiology of hepatitis occurring in childhood, in Canada. Our analyses ... storage and analysis. Efforts were made to check the data records for accuracy and to eliminate any duplication. Audits were conducted at each 3-month interval during the study period in order ... analysis was used to compare the rates of the reported disease over time using: gender, calendar year, age and birthplace, which were the only variables available for denominator data. After...

Báo cáo y học: " Mobile learning for HIV/AIDS healthcare worker training in resource-limited settings." pptx

... plan educational activities accordingto each individual user’s personal age nda was indicatedas an added value by 86.6% of the participants, while94.4% indicated that access to the educational ... lmobile application, allowing knowledge sharing and datacontribution through a mobile-based educationalplatform.Materials and methodsOf 24 Peruvian department capitals, 20 were alreadyinvolved ... hedidactic material in any area of the clinic. This accessalso simultaneously guaranteed wire-free interactions,without participants having to purchase a completecomputer to connect, and reducing...

Báo cáo y học: "Platelet-Activating Factor Antagonists Decrease Follicular Dendritic-Cell Stimulation of Human B Lymphocytes" pptx

... ofspindle-shaped adherent cells in culture and stainednegatively for CD20 and CD3 and positively for CD14 and VLA-4 by flow cytometry (data notshown). In addition, viability testing indicatedthat by ... mediators,11–14it ispossible that mediators such as PAF may assistFDCs in attracting or activating B lymphocytes. In these studies, we determined that a pharmaco-logic antagonist of PAF, ... tonsillar Blymphocytes; lane 5, LA350 B-lymphocyte cell line.Both sources of B lymphocytes have a much strongermRNA signal than the FDCs have. Equal lane loadingwas verified by using ␤-actin as...

Báo cáo y học: "Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases" pot

... [13].CommentaryTargeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseasesThomas A WaldmannMetabolism Branch, Center for Cancer Research, National Cancer Institute, ... and inflammatory chemokines have beeninvoked as pathogenic elements underlying thedevelopment and maintenance of inflammation andautoimmunity [2]. These insights concerning cytokine-mediated ... component of vaccines directed againstcancer or infectious agents.Abnormalities of IL-15 expression in inflammatory autoimmune diseasesIL-15 is a dangerous inflammatory cytokine that inhibitsself-tolerance...

Báo cáo y học: "Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium" pps

... fourchemokines bound to synovial tissue cells in the subin-tima and the intima in every RA and non-RA individual(Supplementary Fig. 1a for CCL5). Radiolabelledchemokine binding was absent in synovia ... These inflamed regions displayed intimal layerthickening and some infiltration of mononuclear cells,although not as severe as in RA samples, and noninflamedsites showed a normal intimal layer and ... rheumatoidtissue. (c) CXCL8 binding to macrophages in a lymphocyte-richinfiltrate in rheumatoid synovium. (d) CCL3 (macrophage inflammatoryprotein-1α) binding to macrophages in the inflamed intimal...

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