Báo cáo y học: "Systemic lupus erythematosus and the type I interferon system" docx

... comprises the inducers of type I IFN synthesis, the type I IFN genes and proteins, the cells pro- ducing type I IFNs, and the target cells affected by the IFNs. The human type I IFN gene family ... observations obviously further raise the question of whether the type I IFN system could be involved in the etiopathogenesis of naturally occurring SLE. T...

Ngày tải lên: 09/08/2014, 01:21

... APRIL and BLyS can form BLyS/APRIL heterotrimers (BAHTs), which do have ‘BLyS-like’ biologic activity in vitro and which do circulate in vivo [25]. Whether BAHTs exert in vivo bio- logic activity ... BLyS antagonist therapy. Those patients with normal circulating BLyS levels might be relatively resistant to BLyS antago- nist therapy, since ‘excess’ BLyS is not driving clinical autoimmunit...

Ngày tải lên: 09/08/2014, 01:21

... (four patients) revealed atrophy of the epidermis, necrosis of some keratinocytes, and perifollicular and perivascular lymphocytic infiltration in the dermis without vas- culitis. No indirect immunofluorescent ... tested by Farr assay and were positive. The patient without anti-DNA had a high titre of ANA, positive anti-ENA and anti-histone antibodies. Positive anti-ENA antibodi...

Ngày tải lên: 09/08/2014, 06:22

... Liverpool University Hospital with responsibility for the NHS diagnostic laboratories in clinical biochemistry. He has a special interest in the hospital for nutritional care of very sick patients. ... McLaughlin obtained the BSc in Medical microbiology at Liverpool University and PhD in tumour immunology at Nottingham University, and is currently a senior lecturer in Immunology w...

Ngày tải lên: 03/11/2012, 09:57

... inhibited by the addition to the mitochondrial suspension of CsA (Fig. 5A), the specific inhibitor of the permeability transition pore of mitochondria [26]. This change in permeability of the inner mitochondrial ... matrix enzyme activities, such as mitochondrial AAT, the release of which was also inhibited by the addition of CsA (Fig. 5B). As the mitochondrial permeability tra...

Ngày tải lên: 24/03/2014, 04:21

... of autoreactive lymphocytes associated with multisystem injury, including nephritis, arthritis, serositis, dermatitis, and blood dyscrasias. Lupus nephritis is mediated in part by local depo- sition of circulating ... MRL mice and CTRL MRL mice. Renal injury MRL mice typically have chronic kidney disease characterized by proteinuria and renal insufficiency. Timed urine collections wer...

Ngày tải lên: 09/08/2014, 10:21

... compression is statistically signifi- cant. Figure 3B also confirms the decline in CMAP dura- tion during compression. There is much variability in this measure and significant differences are ... com- pression but not with velocity during the recovery period. On the other hand, there are positive but statistically insignificant correlations between the changes in velocity during...

Ngày tải lên: 10/08/2014, 10:20

... the CMAP predict injury to the nerve and to know the sen- sitivity and specificity of these predictio ns. In order to answer these questions, multiple linear discriminant analyses were used with all ... accuracy. The specificity and sensitivity of the classifier for stage 8 ver- sus stage 1 is 100% and 84% respectively. When a low stretch force is applied, the normalized v...

Ngày tải lên: 10/08/2014, 10:20

... TLR9 with provide additional insight into the potential therapeutic role of TLR9 inhibition in lupus. Targeting type I interferons in systemic lupus erythematosus The parallel discoveries of the ... TLRs in stimulating type I IFNs, of pDCs as the primary source of this cytokine, and of the IFN-signature in lupus patients by microarray analyses [37,38] have identifi...

Ngày tải lên: 09/08/2014, 10:21

... Euro- pean Working Party on Systemic Lupus Erythematosus: Morbid- ity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort ... apoptotic debris from stimulating and sustaining autoimmunity through inhibition of toll-like receptors 7 and 9. The anti-malarials are immunomodulatory without being immunosu...

Ngày tải lên: 09/08/2014, 14:22