Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not b

Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx

... data suggest that the CD4 + CD25 + regulatory T cells may not be essential for controlling experimentally induced autoimmune arthritis. Competing interests None declared. Acknowledgements The ... effective function of the CD4 + CD25 + regulatory T cells is T- cell receptor (TCR) specific [28]. Collectively, our data suggest that the CD4 + CD25 + regulatory T cells may...

Ngày tải lên : 09/08/2014, 01:21

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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx

... IgG4. In vitro studies demonstrate nonana- phylactogenic activity by blocking of IgE binding. IL-10 reduces release of proinflammatory cytokines by mast cells. The role of IL-10 in costimulatory ... allergen with the immune system starts with handling of it by the antigen-presenting cells, mainly dendritic cells (DCs), which process antigenic material and present it on its surface to...

Ngày tải lên : 08/08/2014, 21:20

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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx

... due to the inability of CD4 + CD25 + Treg to migrate into the inflamed tissue. The authors also pointed out that a ‘true’ curative activity of CD4 + CD25 + Treg has been reported only in colitis ... only a minor blink of an eye in the vast Treg literature, but Frey and colleagues introduce a provocative ‘spin’ to their results as they question the potential of the ‘therapeutic’ role of Tr...

Ngày tải lên : 09/08/2014, 06:23

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Báo cáo y học: "Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells" pps

... vascular endothelium expressed CCL5 protein (Figure 6). In addition, staining was demonstrated at the synovial lining and on many infiltrating inflammatory cells. Protein levels of inflammatory chemokines ... predominantly in CD8+ T cells, in all three subtypes of JIA inves- tigated. Synovial CD8+ T cells also contained high levels of the protein CCL5, which was readily detec...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: " High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis" pot

... shown to delete self-reactive T cells in the thymus in experimental settings [7], but abnormalities in these cells have not yet been implicated in any spontaneous autoimmune model. Although the ... likely that EBV is not the only infection to result in a mutually permissive state of auto- reactivity in RA. Other examples include the increased probability of RF producti...

Ngày tải lên : 09/08/2014, 10:23

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Tài liệu Báo cáo Y học: Granule-bound starch synthase I A major enzyme involved in the biogenesis of B-crystallites in starch granules ppt

... amylopectin synthesis has become minimal, wehavedecidedtoresorttoasemiin vitro system that contains all the native enzymes and structures required for amylose synthesis but lacks the amylopectin ... mutations equally affected the structure of amylopectin. It was therefore impossible to ascertain how amylose participates in starch granule crystallinity. In a previous study we demonstrated...

Ngày tải lên : 22/02/2014, 07:20

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Báo cáo y học: "Characterization of histopathology and gene-expression profiles of synovitis in early rheumatoid arthritis using targeted biopsy specime" pot

... Considering that infiltrating T cells in the rheumatoid synovium in the early stage of RA are predominantly T helper type 1 cells [8], our findings that the degree of lymphoid cell infiltration ... 9) (see Table 1). Written, informed consent was obtained from each patient before they were entered into the study. Synovial specimens in early RA were obtained from knee joints by ta...

Ngày tải lên : 09/08/2014, 06:23

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Báo cáo y học: "The PI3K–NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis" pdf

... Moreover, the incapability of inflammatory cells to undergo apoptosis leads to their accumulation in the joints, thus maintaining the inflammatory process [19- 21]. In the present study we show that ... manifestations of rheumatoid arthritis. In addition, A 3 AR expression in the immune system cells may be sug- gested as a biomarker that reflects the receptor status in rem...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "Frozen Elephant Trunk: A technique which can be offered in complex pathology to fix the whole aorta in one setting" pps

... participated in the coordination and drafting of this text. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Received: ... conven- tional single-stage procedure with combined incisions (thoraco-sternotomy or bilateral anterior thoracotomy) is associated with increased morbidity. A staged proce- duremaybeused,b...

Ngày tải lên : 10/08/2014, 09:21

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Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"

... [10]. The longer primer for detection of the wt allele was 5’-TTC AAG CCC TGA TGA TAA GGT CTT TGG CAT TAG ATG CTG TTT TGT TTT-3.’ The shorter primer was 5’-CTT TTG GCA TTA GAT GCT GTT TTG TCC TG-3.’ ... significant interaction between genotype and coronary heart disease could be detected. Eliminating patients with diabetes mellitus or triglycerides higher than 1.000 mg/dl which likel...

Ngày tải lên : 31/10/2012, 17:03

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