Báo cáo y học: "New hope for haplotype mapping" pptx
Báo cáo y học: "New hope for haplotype mapping" pptx
... technology,without it being necessary to type every DNA variant indi-vidually in an attempt to identify the functional polymor-phism responsible for a disease.Until recently, only a few studies ... haplotype networks that can bedefined by a relatively small number of markers.What then should the gene mappers conclude from theseapparently disparate results? By defining haplotypes veryrigorously, ... coulddefine ancestral haplotypes with LD extending over verylarge distances (up to 3 cM) and that the association ofany one of many alleles could implicate a haplotype asso-ciated with disease....
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Báo cáo y học: ":New tricks for an old-favorite model" pps
... from basic cell biology to the use of yeast for industrial purposes and translational research. Here, I summarize a few highlights related to systems and synthetic biology, yeasts as model organisms ... trans-cription. Microarray analysis for cells grown in low iron supply (simulating iron deficiency) have revealed mRNAs down regulated by Cth2, showing a global metabolic reprogramming driven by a posttranscriptional ... posttranscriptional regulatory process controlled by iron deficiency.Target of rapamycin (TOR) is the central component of a conserved eukaryotic signaling pathway that regulates cell and organismal...
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Báo cáo y học: "Gene profiling for defining targets for new therapeutics in autoimmune diseases" potx
... variability.To exert their functions, type 1 and type 2 T lymphocyteshave to home into different sites. We reported anincreased expression of mRNA for fucosyltransferase VII,which codes for an enzyme ... profiling. I will focus on the gene expressionanalysis of T lymphocytes, the key players in severalinflammatory diseases, and on the microarray analysis ofbrain tissue from patients with multiple ... Murphy KM, Sher A: Functional diversity of helper Tlymphocytes. Nature 1996, 383:787-793.11. O’Garra A: Cytokines induce the development of functionallyheterogenous T helper subsets. Immunity...
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Báo cáo y học: "New insights into integrin signalling: implications for rheumatoid arthritis synovial fibroblasts" pptx
... ade-novirus-mediated csk gene transfer to synoviocytes andosteoclasts. J Clin Invest 1999, 104:137-146.14. Pap T, Franz JK, Hummel KM, Jeisy E, Gay RE, Gay S: Activationof synovial fibroblasts in rheumatoid ... 277:34679-34691.13. Takayanagi H, Juji T, Miyazaki T, Iizuka H, Takahashi T, Isshiki M,Okada M, Tanaka Y, Koshihara Y, Oda H, Kurokawa T, NakamuraK, Tanaka S: Suppression of arthritic bone destruction by ade-novirus-mediated ... activates Src-family kinases and controls inte-grin-mediated responses in fibroblasts. Curr Biol 1999, 9:505-511.6. Pap T, Müller-Ladner U, Gay RE, Gay S: Fibroblast biology. Roleof synovial fibroblasts...
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Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"
... analysis of sol-id-pseudopapillary tumor of the pancreas: report of 15 cases. Hepatobilliary Pancreat Dis Int. 2008;7(2):196-200. 10. Yu CC, Yeh CN, Hwang TL, Jan YY. Clinicopathological study ... primary lesion is proposed. Key words: Diagnosis, Pancreas, Solid pseudopapillary tumor, Surgery Introduction Solid Pseudopapillary T um o r (SPT) of the pan-creas is a very rare entity with ... uncertainty of the strategy for its treatment. While further delineati n g the clinicopathological and radiological features, and summarizing the surgical therapy strategy of this tumor, we hereby...
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Báo cáo y học: "Enhanced surveillance for childhood hepatitis B virus infection in Canada, 1999-2003"
... 0 to 4 years vs 10 -15 years for Canadian-born children 3.56 1.57 to 8.09 5 to 9 years vs 10 -15 years for Canadian-born children 1.10 0.40 to 3.04 0 to 4 years vs 10 -15 years for non-Canadian-born ... laboratories, which were performing confirmatory testing for HB in each jurisdiction, either automatically reported or were contacted regularly for newly identified HB cases, laboratory test results, ... predefined questionnaires for all seven health regions. The notification system was not materially changed during the study period, but augmented throughout by scrutiny of laboratory results and hospital...
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Tài liệu Báo cáo Y học: Systematic search for zinc-binding proteins in Escherichia coli potx
... 1,6-bisphosphatasealdolase4 GlyA Serine hydroxymethyltransferase5 LpdA* (AtpA) Lipoamide dehydrogenase(F1 ATP synthase a subunit)6 Ppa* (AhpC) Inorganic pyrophosphatase(alkyl hydroperoxide reductase ... BL21. For purification of zinc-binding proteins, cells were lysedin lysis buffer containing 0.2 mgÆmL)1lysozyme, 0.2 mMphenylmethanesulfonyl fluoride and 1 mMdithiothreitol,followed by sonication. ... LAS-1000 image analyser(Fuji Film Co., Japan). Sp1 was kindly donated by Y. Sugiura (Kyoto University, Japan). RESULTSZinc-binding assay of totalE. coliproteinsfractionated by two dimensional...
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Báo cáo khoa học: " New Models for Improving Supertag Disambiguation" pdf
... increase in ambiguity for significantly higher accu- racy. Different class based methods are discussed, and the tradeoff between accuracy and ambiguity is demonstrated. 7Again, for the class C ... information for the sentences of one of the languages, one can rapidly develop a gram- mar for the other language using supertagging, as suggested by Bangalore (1998). In contrast to the aforementioned ... assignment for a particular word respec- tively, and t ect is the correct supertag. Sub- sequently, on the test data, each classifier pair votes, weighted by overall accuracy, for the su-...
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Báo cáo khoa học: New evidence for the role of calcium in the glycosidase reaction of GH43 arabinanases pot
... importance for this type of pro-tein. In enzymatic assays performed with both mutants,there was a drastic decrease in enzymatic activity isobserved for the H318A mutant, and enzymatic activitywas ... areresponsible for the general acid catalysis that leads tohydrolysis of the glycosidic bond. Within GH family43, the enzymes work by an inversion mechanism, inwhich one carboxylate acts as ... havepreviously reported the crystallization and preliminaryX-ray analysis of BsArb42B [18]. Here we present the3D structure of the wild-type enzyme and describemutant proteins, providing new evidence for...
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc
... namely that they contain ahydrogen-bond donor in wing2. This property is of generalimportance for the efficacy of the inhibitor. Substitution ofthe hydrogen-donating amide group for a methylene ... programs for r eformatting, a nalysis and manipulationof biomacromolecular electron-density maps and reflection datasets. Acta Crystallogr. D52, 826–828.27. Kleywegt, G.J. (1996) Use of non-crystallographic ... efficacy (Eur. J. Biochem. 269) 1677with the r anking of the compounds with respect to theirinhibitory efficacy. However, these factors may not solelyaccount for t he total reduction in inhibitory...
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