Báo cáo y học: "Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease" pptx

... http://arthritis-research.com/content/5/1/25 25 AERD = aspirin-exacerbated respiratory disease; COX = cyclooxygenase; cys-LT = cysteinyl leukotriene; LT = leukotriene; NSAIDs = non-steroidal anti-inflammatory drugs; PG = prostaglandin. Available ... inflammatory cells are increased in the submucosa of aspirin-sensitive asthmat- Commentary COX-2: where are we in 2003? Specific cyclooxygen...

Ngày tải lên: 09/08/2014, 01:21

... Med. Sci. 2007, 4 137 tory effect of thioglycoside I (phenyl-1’-thio-β-D glucopyranoside) on hSGLT2 and thioglycoside VII (2-hydroxymethyl-phenyl-1’-thio-β-D-galactopyranosi de) on hSGLT1. Studies ... chemical synthesized [13, 14]. The most commonly used is known as T-1095 (3-(benzofuran-5-yl)-2',6'-dihydroxy-4'-methylpropio- phenone 2'-O-(6-O-methoxycarbonyl-β-D-...

Ngày tải lên: 26/10/2012, 10:04

... [poly(ADP-ribose) polymerase-1] inhibitors kill breast cancer associated gene-1 and –2 (BRCA1/2) deficient cells with extremely high efficiency while BRCA+/- and BRCA+/+ cells are relatively ... motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 1997; 272: 31941-4. 29. Bryant HE, and Helleday T. Poly(ADP-ribose) polymerase inhibitors as potential chemothera...

Ngày tải lên: 31/10/2012, 16:57

... gelatin zymography, and collagenase activity assays using both SW1353 chondrosarcoma cells and primary human chondrocytes. The HDAC inhibitors trichostatin A and sodium butyrate potently inhibit ... assayed using the dimethylmethylene blue method. Collagen release is shown as at day 14 and was measured using an assay for hydroxyproline. Viability was assessed by measuring lactate...

Ngày tải lên: 09/08/2014, 06:22

... microscopy localization of the 11beta-hydroxysteroid dehydrogenase type I enzyme in the rat. Endocrinology 2001, 142:1644-1651. 20. Sun K, Myatt L: Enhancement of glucocorticoid-induced 11beta-hydroxysteroid ... 11beta-hydroxysteroid dehydrogenase type 1 in type 2 dia- betic myotubes. Eur J Clin Invest 2005, 35:627-634. 18. Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hern- andez M,...

Ngày tải lên: 09/08/2014, 08:22

... efficacy of PPIs and H2RAs in the primary prevention of clinically relevant endpoints, such as bleeding and perforated NSAID ulcers, remains unproven. The discovery of the isoenzymes cyclooxygenase ... endoscopy, surgery and pathology. Medication use before and during hospitalisa- tion, as reported by the patient, was verified by reviewing pre- scription registrations provided by the...

Ngày tải lên: 09/08/2014, 10:20

... Interview Survey (NHIS) approach of disability days and partial days in bed [33]. Still others have used work loss days and days worked but with productivity reduced by half or more [34]. Similar subjective ... this year and will fully describe the findings from the latest meeting. In capturing work absences due to arthritis, we considered both full and partial days (that is, days of...

Ngày tải lên: 09/08/2014, 14:21

... Crystallography 2007, 40(3):598-599. 12. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and ... biochemical reactions including mono- and poly-ADP ribosyl ation (ART and PARP cata- lyzed), protein deacetylation and ADP-ribose cyclization [3]. NMPRTase catalyzes the conversion of fre...

Ngày tải lên: 10/08/2014, 09:22

... Experimental and Clinical Pharmacology and Tox- icology, Freiburg, Germany). Y2 7632, is a well established inhibitor of ROCK in a vari- ety of systems. This pyridine derivative is the oldest syn- thesised ... Stark 1 and Eva M Lang* 1 Address: 1 Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Freiburg, Germany and 2 Institute of Experimental and...

Ngày tải lên: 10/08/2014, 10:20

Ngày tải lên: 25/10/2012, 10:02