Báo cáo y học: "Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease" pptx
Báo cáo y học: "Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory disease" pptx
... http://arthritis-research.com/content/5/1/2525AERD = aspirin-exacerbated respiratory disease; COX = cyclooxygenase; cys-LT = cysteinyl leukotriene; LT = leukotriene; NSAIDs = non-steroidalanti-inflammatory drugs; PG = prostaglandin.Available ... inflammatory cells areincreased in the submucosa of aspirin-sensitive asthmat-CommentaryCOX-2: where are we in 2003?Specific cyclooxygenase-2 inhibitors and aspirin-exacerbated respiratory diseaseLeslie ... granulocyte functions [4]. PGs are pro-duced through an enzymatic pathway that includes theCOX enzymes. Both the COX-1 and COX-2 isoforms areexpressed in the respiratory epithelium (basal and...
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Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... Med. Sci. 2007, 4 137tory effect of thioglycoside I (phenyl-1’-thio-β-D glucopyranoside) on hSGLT2 and thioglycoside VII (2-hydroxymethyl-phenyl-1’-thio-β-D-galactopyranoside) on hSGLT1. Studies ... chemical synthesized [13, 14]. The most commonly used is known as T-1095 (3-(benzofuran-5-yl)-2',6'-dihydroxy-4'-methylpropio-phenone 2'-O-(6-O-methoxycarbonyl-β-D-glyco- pyranoside) ... differen-tiate between hSGLT1 and hSGLT2. As a consequence, the data obtained by thioglucoside I (phenyl-1’-thio-β-D-glucopyranoside) and VII (2-hydroxymethyl-phenyl-1’-thio-β-D-galactopyranoside) on inhibition...
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Báo cáo y học: "PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers"
... [poly(ADP-ribose) polymerase-1] inhibitors kill breast cancer associated gene-1 and –2 (BRCA1/2) deficient cells with extremely high efficiency while BRCA+/- and BRCA+/+ cells are relatively ... motifs in the human breast cancer susceptibility gene brca2. J Biol Chem 1997; 272: 31941-4. 29. Bryant HE, and Helleday T. Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents. ... PARP-1 inhibitors specifically kill human BRCA2-deficient pancreatic cancer cells? Because PARP-1-null mice are viable and healthy [32], and inhibitors that are specific for PARP-1 are relatively...
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Báo cáo y học: "Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption" ppt
... gelatin zymography, and collagenase activity assays using both SW1353chondrosarcoma cells and primary human chondrocytes. TheHDAC inhibitors trichostatin A and sodium butyrate potentlyinhibit ... assayed using the dimethylmethylene blue method. Collagen release is shown as at day 14 and was measured using an assay for hydroxyproline. Viability was assessed by measuring lactate dehydrogenase ... allinduced by IL-1α and OSM and the induction was repressedby HDAC inhibitors (Fig. 3c). These primary chondrocytes,although grown in monolayer culture, still express type II colla-gen and aggrecan...
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Báo cáo y học: "Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation" pps
... microscopy localization of the11beta-hydroxysteroid dehydrogenase type I enzyme in therat. Endocrinology 2001, 142:1644-1651.20. Sun K, Myatt L: Enhancement of glucocorticoid-induced11beta-hydroxysteroid ... 11beta-hydroxysteroid dehydrogenase type 1 in type 2 dia-betic myotubes. Eur J Clin Invest 2005, 35:627-634.18. Hermanowski-Vosatka A, Balkovec JM, Cheng K, Chen HY, Hern-andez M, Koo GC, Le Grand ... 11beta-hydroxysteroid dehydroge-nase type 1 activity increases with age and glucocorticoidexposure. J Bone Miner Res 2002, 17:979-986.12. Mazancova K, Kopecky M, Miksik I, Pacha J: 11beta-Hydroxyster-oid...
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Báo cáo y học: "Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study" pptx
... efficacy of PPIs and H2RAs inthe primary prevention of clinically relevant endpoints, such asbleeding and perforated NSAID ulcers, remains unproven.The discovery of the isoenzymes cyclooxygenase ... endoscopy, surgery and pathology. Medication use before and during hospitalisa-tion, as reported by the patient, was verified by reviewing pre-scription registrations provided by the in-hospital and community-based ... The large randomised controlled clinical trials thatdemonstrated the efficacy and safety of selective COX-2 inhibitors were conducted in relatively young, healthy subjects.Our study suggests...
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Báo cáo y học: "Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA)" potx
... InterviewSurvey (NHIS) approach of disability days and partial days inbed [33]. Still others have used work loss days and daysworked but with productivity reduced by half or more [34].Similar subjective ... this year and will fully describe thefindings from the latest meeting.In capturing work absences due to arthritis, we consideredboth full and partial days (that is, days of work missed and dayswith ... baseline responses by HAQ-DI and SF-36: home productivity and daily activities of all randomly assigned subjects in the modified intent-to-treat populationInstrumentaNumber of days of household...
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Báo cáo y học: "Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/ NMPRTase for glioma therap" doc
... Crystallography 2007,40(3):598-599.12. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ: Experimental and computational approaches to estimate solubility and permeability indrug discovery and ... biochemical reactions includingmono- and poly-ADP ribosyl ation (ART and PARP cata-lyzed), protein deacetylation and ADP-ribose cyclization[3]. NMPRTase catalyzes the conversion of free nicotina-mide ... the hydrophobic and aromatic interactions, hydrogenbonding interactions with F193, G353, G384 , R196,H247 and R311 of one subunit and Y1 8 of another sub-unit in the first mode; and Y1 88 and...
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Báo cáo y học: "Rho kinase inhibitors Y27632 and H1152 augment neurite extension in the presence of cultured Schwann cells" pdf
... Experimental and Clinical Pharmacology and Tox-icology, Freiburg, Germany). Y2 7632, is a well established inhibitor of ROCK in a vari-ety of systems. This pyridine derivative is the oldest syn-thesised ... Stark1 and Eva M Lang*1Address: 1Department of Plastic and Hand Surgery, University of Freiburg Medical Centre, Freiburg, Germany and 2Institute of Experimental and Clinical Pharmacology and ... and reported specific inhibitor of Rho-kinasefamily enzymes. Y2 7632 inhibits ROCK activity by com-petitive binding with ATP to the catalytic domain. Y2 7632is reported to have a specificity...
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